Pictured is a confocal image of a mosquito testicle stained for DNA (with DAPI, shown in red) overlaid with the expression pattern of the eGFP-tagged I-PpoI endonuclease protein (shown in green). The testis hub region (lower right part of the picture) does not stain for eGFP, suggesting that stem cells are not affected by the potentially toxic endonuclease. Expression of the protein during later stages of spermatogenesis induced dominant male sterility and sex chromosome transmission ratio distortion, without disrupting the production of functional sperm (see Windbichler et al., doi:10.1371/journal.pgen.1000291).
Image Credit: Image generated by Philippos Aris Papathanos (Imperial College, London).
Interview
Taken to School: An Interview with the Honorable Judge John E. Jones, III
PLOS Genetics: published December 5, 2008 | https://doi.org/10.1371/journal.pgen.1000297
Perspective
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