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A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections between Pre–mRNA Splicing and 5′ and 3′ End Transcript Determinants

Laura-Oana Albulescu, Nevin Sabet, Mohanram Gudipati, Nicholas Stepankiw, Zane J. Bergman, Tim C. Huffaker, Jeffrey A. Pleiss

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002530

LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients

MyLinh T. Duong, Said Akli, Caimiao Wei, Hannah F. Wingate, Wenbin Liu, Yiling Lu, Min Yi, Gordon B. Mills, Kelly K. Hunt, Khandan Keyomarsi

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002538

Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells

Daisuke Sakai, Jill Dixon, Michael J. Dixon, Paul A. Trainor

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002566

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, Claudia Hundertmark, Meredith C. Foster, Conall M. O'Seaghdha, Nicole Glazer, Aaron Isaacs, Ching-Ti Liu, Albert V. Smith, Jeffrey R. O'Connell, Maksim Struchalin, Toshiko Tanaka, Guo Li, Andrew D. Johnson, Hinco J. Gierman, Mary Feitosa, Shih-Jen Hwang, Elizabeth J. Atkinson, Kurt Lohman, Marilyn C. Cornelis, Åsa Johansson, Anke Tönjes, Abbas Dehghan, Vincent Chouraki, Elizabeth G. Holliday, Rossella Sorice, Zoltan Kutalik, Terho Lehtimäki, Tõnu Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Y. Chu, Federico Murgia, Stella Trompet, Medea Imboden, Barbara Kollerits, Giorgio Pistis, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Tamara B. Harris, Lenore J. Launer, Thor Aspelund, Gudny Eiriksdottir, Braxton D. Mitchell, Eric Boerwinkle, Helena Schmidt, Margherita Cavalieri, Madhumathi Rao, Frank B. Hu, Ayse Demirkan, Ben A. Oostra, Mariza de Andrade, Stephen T. Turner, Jingzhong Ding, Jeanette S. Andrews, Barry I. Freedman, Wolfgang Koenig, Thomas Illig, Angela Döring, H.-Erich Wichmann, Ivana Kolcic, Tatijana Zemunik, Mladen Boban, Cosetta Minelli, Heather E. Wheeler, Wilmar Igl, Ghazal Zaboli, Sarah H. Wild, Alan F. Wright, Harry Campbell, David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Reiner Biffar, Karlhans Endlich, Florian Ernst, Georg Homuth, Heyo K. Kroemer, Matthias Nauck, Sylvia Stracke, Uwe Völker, Henry Völzke, Peter Kovacs, Michael Stumvoll, Reedik Mägi, Albert Hofman, Andre G. Uitterlinden, Fernando Rivadeneira, Yurii S. Aulchenko, Ozren Polasek, Nick Hastie, Veronique Vitart, Catherine Helmer, Jie Jin Wang, Daniela Ruggiero, Sven Bergmann, Mika Kähönen, Jorma Viikari, Tiit Nikopensius, Michael Province, Shamika Ketkar, Helen Colhoun, Alex Doney, Antonietta Robino, Franco Giulianini, Bernhard K. Krämer, Laura Portas, Ian Ford, Brendan M. Buckley, Martin Adam, Gian-Andri Thun, Bernhard Paulweber, Margot Haun, Cinzia Sala, Marie Metzger, Paul Mitchell, Marina Ciullo, Stuart K. Kim, Peter Vollenweider, Olli Raitakari, Andres Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J. Wouter Jukema, Nicole M. Probst-Hensch, Florian Kronenberg, Daniela Toniolo, Vilmundur Gudnason, Alan R. Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, David S. Siscovick, Cornelia M. van Duijn, Ingrid Borecki, Sharon L. R. Kardia, Yongmei Liu, Gary C. Curhan, Igor Rudan, Ulf Gyllensten, James F. Wilson, Andre Franke, Peter P. Pramstaller, Rainer Rettig, Inga Prokopenko, Jacqueline C. M. Witteman, Caroline Hayward, Paul Ridker, Afshin Parsa, Murielle Bochud, Iris M. Heid, Wolfram Goessling, Daniel I. Chasman, W. H. Linda Kao, Caroline S. Fox

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002584

Intronic Cis-Regulatory Modules Mediate Tissue-Specific and Microbial Control of angptl4/fiaf Transcription

J. Gray Camp, Amelia L. Jazwa, Chad M. Trent, John F. Rawls

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002585

Phenotypic Plasticity of the Drosophila Transcriptome

Shanshan Zhou, Terry G. Campbell, Eric A. Stone, Trudy F. C. Mackay, Robert R. H. Anholt

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002593

PIF4–Mediated Activation of YUCCA8 Expression Integrates Temperature into the Auxin Pathway in Regulating Arabidopsis Hypocotyl Growth

Jiaqiang Sun, Linlin Qi, Yanan Li, Jinfang Chu, Chuanyou Li

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002594

The Transcription Factor Ultraspiracle Influences Honey Bee Social Behavior and Behavior-Related Gene Expression

Seth A. Ament, Ying Wang, Chieh-Chun Chen, Charles A. Blatti, Feng Hong, Zhengzheng S. Liang, Nicolas Negre, Kevin P. White, Sandra L. Rodriguez-Zas, Craig A. Mizzen, Saurabh Sinha, Sheng Zhong, Gene E. Robinson

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002596

Critical Evaluation of Imprinted Gene Expression by RNA–Seq: A New Perspective

Brian DeVeale, Derek van der Kooy, Tomas Babak

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002600

The Atypical Calpains: Evolutionary Analyses and Roles in Caenorhabditis elegans Cellular Degeneration

Peter I. Joyce, Rahul Satija, Maozi Chen, Patricia E. Kuwabara

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002602

Balanced Codon Usage Optimizes Eukaryotic Translational Efficiency

Wenfeng Qian, Jian-Rong Yang, Nathaniel M. Pearson, Calum Maclean, Jianzhi Zhang

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002603

Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A.Z Insertion to Establish Nucleosome Depleted Regions

Xiaojing Yang, Houtan Noushmehr, Han Han, Claudia Andreu-Vieyra, Gangning Liang, Peter A. Jones

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002604

The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum Development

Carine Benadiba, Dario Magnani, Mathieu Niquille, Laurette Morlé, Delphine Valloton, Homaira Nawabi, Aouatef Ait-Lounis, Belkacem Otsmane, Walter Reith, Thomas Theil, Jean-Pierre Hornung, Cécile Lebrand, Bénédicte Durand

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002606

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger, Toshiko Tanaka, Andrew P. Morris, Kerrin Small, Aaron Isaacs, Marian Beekman, Stefan Coassin, Kurt Lohman, Lu Qi, Stavroula Kanoni, James S. Pankow, Hae-Won Uh, Ying Wu, Aurelian Bidulescu, Laura J. Rasmussen-Torvik, Celia M. T. Greenwood, Martin Ladouceur, Jonna Grimsby, Alisa K. Manning, Ching-Ti Liu, Jaspal Kooner, Vincent E. Mooser, Peter Vollenweider, Karen A. Kapur, John Chambers, Nicholas J. Wareham, Claudia Langenberg, Rune Frants, Ko Willems-vanDijk, Ben A. Oostra, Sara M. Willems, Claudia Lamina, Thomas W. Winkler, Bruce M. Psaty, Russell P. Tracy, Jennifer Brody, Ida Chen, Jorma Viikari, Mika Kähönen, Peter P. Pramstaller, David M. Evans, Beate St. Pourcain, Naveed Sattar, Andrew R. Wood, Stefania Bandinelli, Olga D. Carlson, Josephine M. Egan, Stefan Böhringer, Diana van Heemst, Lyudmyla Kedenko, Kati Kristiansson, Marja-Liisa Nuotio, Britt-Marie Loo, Tamara Harris, Melissa Garcia, Alka Kanaya, Margot Haun, Norman Klopp, H.-Erich Wichmann, Panos Deloukas, Efi Katsareli, David J. Couper, Bruce B. Duncan, Margreet Kloppenburg, Linda S. Adair, Judith B. Borja, DIAGRAM+ Consortium, MAGIC Consortium, GLGC Investigators, MuTHER Consortium, James G. Wilson, Solomon Musani, Xiuqing Guo, Toby Johnson, Robert Semple, Tanya M. Teslovich, Matthew A. Allison, Susan Redline, Sarah G. Buxbaum, Karen L. Mohlke, Ingrid Meulenbelt, Christie M. Ballantyne, George V. Dedoussis, Frank B. Hu, Yongmei Liu, Bernhard Paulweber, Timothy D. Spector, P. Eline Slagboom, Luigi Ferrucci, Antti Jula, Markus Perola, Olli Raitakari, Jose C. Florez, Veikko Salomaa, Johan G. Eriksson, Timothy M. Frayling, Andrew A. Hicks, Terho Lehtimäki, George Davey Smith, David S. Siscovick, Florian Kronenberg, Cornelia van Duijn, Ruth J. F. Loos, Dawn M. Waterworth, James B. Meigs, Josee Dupuis, J. Brent Richards

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002607

Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin

Célia Floquet, Isabelle Hatin, Jean-Pierre Rousset, Laure Bidou

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002608

Igf1r Signaling Is Indispensable for Preimplantation Development and Is Activated via a Novel Function of E-cadherin

Ivan Bedzhov, Ewa Liszewska, Benoît Kanzler, Marc P. Stemmler

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002609

Accurate Prediction of Inducible Transcription Factor Binding Intensities In Vivo

Michael J. Guertin, André L. Martins, Adam Siepel, John T. Lis

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002610

Metabolic Profiling of a Mapping Population Exposes New Insights in the Regulation of Seed Metabolism and Seed, Fruit, and Plant Relations

David Toubiana, Yaniv Semel, Takayuki Tohge, Romina Beleggia, Luigi Cattivelli, Leah Rosental, Zoran Nikoloski, Dani Zamir, Alisdair R. Fernie, Aaron Fait

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002612

Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain

Ryan K. Shultzaberger, Sebastian J. Maerkl, Jack F. Kirsch, Michael B. Eisen

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002614

SMG-1 and mTORC1 Act Antagonistically to Regulate Response to Injury and Growth in Planarians

Cristina González-Estévez, Daniel A. Felix, Matthew D. Smith, Jordi Paps, Simon J. Morley, Victoria James, Tyson V. Sharp, A. Aziz Aboobaker

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002619

Diverse Forms of RPS9 Splicing Are Part of an Evolving Autoregulatory Circuit

Alex M. Plocik, Christine Guthrie

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002620

Genetic Analysis of Floral Symmetry in Van Gogh's Sunflowers Reveals Independent Recruitment of CYCLOIDEA Genes in the Asteraceae

Mark A. Chapman, Shunxue Tang, Dörthe Draeger, Savithri Nambeesan, Hunter Shaffer, Jessica G. Barb, Steven J. Knapp, John M. Burke

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002628

Phosphorylation of the Drosophila melanogaster RNA–Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity

Ronit Nir, Rona Grossman, Ze'ev Paroush, Talila Volk

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002632

DNA Resection at Chromosome Breaks Promotes Genome Stability by Constraining Non-Allelic Homologous Recombination

Frederick J. Tan, Margaret L. Hoang, Douglas Koshland

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002633

Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits

Shashaank Vattikuti, Juen Guo, Carson C. Chow

PLOS Genetics: published March 29, 2012 | https://doi.org/10.1371/journal.pgen.1002637

Contrasted Patterns of Molecular Evolution in Dominant and Recessive Self-Incompatibility Haplotypes in Arabidopsis

Pauline M. Goubet, Hélène Bergès, Arnaud Bellec, Elisa Prat, Nicolas Helmstetter, Sophie Mangenot, Sophie Gallina, Anne-Catherine Holl, Isabelle Fobis-Loisy, Xavier Vekemans, Vincent Castric

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002495

EMF1 and PRC2 Cooperate to Repress Key Regulators of Arabidopsis Development

Sang Yeol Kim, Jungeun Lee, Leor Eshed-Williams, Daniel Zilberman, Z. Renee Sung

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002512

APOBEC3G-Induced Hypermutation of Human Immunodeficiency Virus Type-1 Is Typically a Discrete “All or Nothing” Phenomenon

Andrew E. Armitage, Koen Deforche, Chih-hao Chang, Edmund Wee, Beatrice Kramer, John J. Welch, Jan Gerstoft, Lars Fugger, Andrew McMichael, Andrew Rambaut, Astrid K. N. Iversen

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002550

The Min System and Nucleoid Occlusion Are Not Required for Identifying the Division Site in Bacillus subtilis but Ensure Its Efficient Utilization

Christopher D. A. Rodrigues, Elizabeth J. Harry

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002561

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Seung-Yon Lee, Julia Heisig, Cornelia Wiese, Kameswaran Surendran, Raphael Kopan, Manfred Gessler, Fanxin Long

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002577

Evidence for Positive Selection on a Number of MicroRNA Regulatory Interactions during Recent Human Evolution

Jingjing Li, Yu Liu, Xiaofeng Xin, Taehyung Simon Kim, Eduardo Aguiar Cabeza, Jie Ren, Rasmus Nielsen, Jeffrey L. Wrana, Zhaolei Zhang

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002578

lin-28 Controls the Succession of Cell Fate Choices via Two Distinct Activities

Bhaskar Vadla, Kevin Kemper, Jennifer Alaimo, Christian Heine, Eric G. Moss

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002588

Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages

Maggie L. Chow, Tiziano Pramparo, Mary E. Winn, Cynthia Carter Barnes, Hai-Ri Li, Lauren Weiss, Jian-Bing Fan, Sarah Murray, Craig April, Haim Belinson, Xiang-Dong Fu, Anthony Wynshaw-Boris, Nicholas J. Schork, Eric Courchesne

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002592

Cis-by-Trans Regulatory Divergence Causes the Asymmetric Lethal Effects of an Ancestral Hybrid Incompatibility Gene

Shamoni Maheshwari, Daniel A. Barbash

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002597

Broad-Specificity mRNA–rRNA Complementarity in Efficient Protein Translation

Pamela A. Barendt, Najaf A. Shah, Gregory A. Barendt, Casim A. Sarkar

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002598

Widespread Site-Dependent Buffering of Human Regulatory Polymorphism

Matthew T. Maurano, Hao Wang, Tanya Kutyavin, John A. Stamatoyannopoulos

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002599

A Fundamental Regulatory Mechanism Operating through OmpR and DNA Topology Controls Expression of Salmonella Pathogenicity Islands SPI-1 and SPI-2

Andrew D. S. Cameron, Charles J. Dorman

PLOS Genetics: published March 22, 2012 | https://doi.org/10.1371/journal.pgen.1002615

An Alu Element–Associated Hypermethylation Variant of the POMC Gene Is Associated with Childhood Obesity

Peter Kuehnen, Mona Mischke, Susanna Wiegand, Christine Sers, Bernhard Horsthemke, Susanne Lau, Thomas Keil, Young-Ae Lee, Annette Grueters, Heiko Krude

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002543

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

Christina M. Lill, Johannes T. Roehr, Matthew B. McQueen, Fotini K. Kavvoura, Sachin Bagade, Brit-Maren M. Schjeide, Leif M. Schjeide, Esther Meissner, Ute Zauft, Nicole C. Allen, Tian Liu, Marcel Schilling, Kari J. Anderson, Gary Beecham, Daniela Berg, Joanna M. Biernacka, Alexis Brice, Anita L. DeStefano, Chuong B. Do, Nicholas Eriksson, Stewart A. Factor, Matthew J. Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A. Hardy, Peter Heutink, Erin M. Hill-Burns, Christine Klein, Jeanne C. Latourelle, Demetrius M. Maraganore, Eden R. Martin, Maria Martinez, Richard H. Myers, Michael A. Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K. Scott, Manu Sharma, Andrew B. Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y. Tung, Jeffery Vance, Nick W. Wood, Cyrus P. Zabetian, 23andMe, The Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium, The International Parkinson's Disease Genomics Consortium (IPDGC), The Parkinson's Disease GWAS Consortium, The Wellcome Trust Case Control Consortium 2 (WTCCC2), Peter Young, Rudolph E. Tanzi, Muin J. Khoury, Frauke Zipp, Hans Lehrach, John P. A. Ioannidis, Lars Bertram

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002548

Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates

Ju-Ling Liu, David Desjardins, Robyn Branicky, Luis B. Agellon, Siegfried Hekimi

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002553

Mapping the Hsp90 Genetic Interaction Network in Candida albicans Reveals Environmental Contingency and Rewired Circuitry

Stephanie Diezmann, Magali Michaut, Rebecca S. Shapiro, Gary D. Bader, Leah E. Cowen

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002562

Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure

Emília Ilona Gaál, Perttu Salo, Kati Kristiansson, Karola Rehnström, Johannes Kettunen, Antti-Pekka Sarin, Mika Niemelä, Antti Jula, Olli T. Raitakari, Terho Lehtimäki, Johan G. Eriksson, Elisabeth Widen, Murat Günel, Mitja Kurki, Mikael von und zu Fraunberg, Juha E. Jääskeläinen, Juha Hernesniemi, Marjo-Riitta Järvelin, Anneli Pouta, The International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS), Christopher Newton-Cheh, Veikko Salomaa, Aarno Palotie, Markus Perola

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002563

Autoregulation of the Drosophila Noncoding roX1 RNA Gene

Chiat Koo Lim, Richard L. Kelley

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002564

The Nucleoside Diphosphate Kinase Gene Nme3 Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance

Hermann Bauer, Sabrina Schindler, Yves Charron, Jürgen Willert, Barica Kusecek, Bernhard G. Herrmann

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002567

Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans

Pawel K. Olszewski, Jan Rozman, Josefin A. Jacobsson, Birgit Rathkolb, Siv Strömberg, Wolfgang Hans, Anica Klockars, Johan Alsiö, Ulf Risérus, Lore Becker, Sabine M. Hölter, Ralf Elvert, Nicole Ehrhardt, Valérie Gailus-Durner, Helmut Fuchs, Robert Fredriksson, Eckhard Wolf, Thomas Klopstock, Wolfgang Wurst, Allen S. Levine, Claude Marcus, Martin Hrabě de Angelis, Martin Klingenspor, Helgi B. Schiöth, Manfred W. Kilimann

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002568

Genetic Architecture of Highly Complex Chemical Resistance Traits across Four Yeast Strains

Ian M. Ehrenreich, Joshua Bloom, Noorossadat Torabi, Xin Wang, Yue Jia, Leonid Kruglyak

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002570

Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates Wnt5a

Li Chen, Filomena Gabriella Fulcoli, Rosa Ferrentino, Stefania Martucciello, Elizabeth A. Illingworth, Antonio Baldini

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002571

Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1^+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

Daniel Haag, Petra Zipper, Viola Westrich, Daniela Karra, Karin Pfleger, Grischa Toedt, Frederik Blond, Nicolas Delhomme, Meinhard Hahn, Julia Reifenberger, Guido Reifenberger, Peter Lichter

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002572

Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis

Lisa M. Nilsson, Tacha Zi Plym Forshell, Sara Rimpi, Christiane Kreutzer, Walter Pretsch, Georg W. Bornkamm, Jonas A. Nilsson

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002573

Temporal Transcriptional Profiling of Somatic and Germ Cells Reveals Biased Lineage Priming of Sexual Fate in the Fetal Mouse Gonad

Samantha A. Jameson, Anirudh Natarajan, Jonah Cool, Tony DeFalco, Danielle M. Maatouk, Lindsey Mork, Steven C. Munger, Blanche Capel

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002575

Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal

Julie Hunkapiller, Yin Shen, Aaron Diaz, Gerard Cagney, David McCleary, Miguel Ramalho-Santos, Nevan Krogan, Bing Ren, Jun S. Song, Jeremy F. Reiter

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002576

Promoter Nucleosome Organization Shapes the Evolution of Gene Expression

Dalia Rosin, Gil Hornung, Itay Tirosh, Ariel Gispan, Naama Barkai

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002579

Variation in MSRA Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis

Lindsay B. Henderson, Vishal K. Doshi, Scott M. Blackman, Kathleen M. Naughton, Rhonda G. Pace, Jackob Moskovitz, Michael R. Knowles, Peter R. Durie, Mitchell L. Drumm, Garry R. Cutting

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002580

A Splice Site Variant in the Bovine RNF11 Gene Compromises Growth and Regulation of the Inflammatory Response

Arnaud Sartelet, Tom Druet, Charles Michaux, Corinne Fasquelle, Sarah Géron, Nico Tamma, Zhiyan Zhang, Wouter Coppieters, Michel Georges, Carole Charlier

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002581

Antagonistic Regulation of Apoptosis and Differentiation by the Cut Transcription Factor Represents a Tumor-Suppressing Mechanism in Drosophila

Zongzhao Zhai, Nati Ha, Fani Papagiannouli, Anne Hamacher-Brady, Nathan Brady, Sebastian Sorge, Daniela Bezdan, Ingrid Lohmann

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002582

The Yeast Forkhead Transcription Factors Fkh1 and Fkh2 Regulate Lifespan and Stress Response Together with the Anaphase-Promoting Complex

Spike D. L. Postnikoff, Mackenzie E. Malo, Berchman Wong, Troy A. A. Harkness

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002583

ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster

Beika Lu, Angela LaMora, Yishan Sun, Michael J. Welsh, Yehuda Ben-Shahar

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002587

A Genome-Wide Association Study Identifies Variants Underlying the Arabidopsis thaliana Shade Avoidance Response

Daniele L. Filiault, Julin N. Maloof

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002589

A Systematic Analysis of Cell Cycle Regulators in Yeast Reveals That Most Factors Act Independently of Cell Size to Control Initiation of Division

Scott A. Hoose, Jeremy A. Rawlings, Michelle M. Kelly, M. Camille Leitch, Qotaiba O. Ababneh, Juan P. Robles, David Taylor, Evelyn M. Hoover, Bethel Hailu, Kayla A. McEnery, S. Sabina Downing, Deepika Kaushal, Yi Chen, Alex Rife, Kirtan A. Brahmbhatt, Roger Smith III, Michael Polymenis

PLOS Genetics: published March 15, 2012 | https://doi.org/10.1371/journal.pgen.1002590

Precocious Metamorphosis in the Juvenile Hormone–Deficient Mutant of the Silkworm, Bombyx mori

Takaaki Daimon, Toshinori Kozaki, Ryusuke Niwa, Isao Kobayashi, Kenjiro Furuta, Toshiki Namiki, Keiro Uchino, Yutaka Banno, Susumu Katsuma, Toshiki Tamura, Kazuei Mita, Hideki Sezutsu, Masayoshi Nakayama, Kyo Itoyama, Toru Shimada, Tetsuro Shinoda

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002486

A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

Rehan Qayyum, Beverly M. Snively, Elad Ziv, Michael A. Nalls, Yongmei Liu, Weihong Tang, Lisa R. Yanek, Leslie Lange, Michele K. Evans, Santhi Ganesh, Melissa A. Austin, Guillaume Lettre, Diane M. Becker, Alan B. Zonderman, Andrew B. Singleton, Tamara B. Harris, Emile R. Mohler, Benjamin A. Logsdon, Charles Kooperberg, Aaron R. Folsom, James G. Wilson, Lewis C. Becker, Alexander P. Reiner

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002491

Three Essential Ribonucleases—RNase Y, J1, and III—Control the Abundance of a Majority of Bacillus subtilis mRNAs

Sylvain Durand, Laetitia Gilet, Philippe Bessières, Pierre Nicolas, Ciarán Condon

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002520

A Natural System of Chromosome Transfer in Yersinia pseudotuberculosis

Biliana Lesic, Mohamed Zouine, Magaly Ducos-Galand, Christèle Huon, Marie-Laure Rosso, Marie-Christine Prévost, Didier Mazel, Elisabeth Carniel

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002529

A Machine Learning Approach for Identifying Novel Cell Type–Specific Transcriptional Regulators of Myogenesis

Brian W. Busser, Leila Taher, Yongsok Kim, Terese Tansey, Molly J. Bloom, Ivan Ovcharenko, Alan M. Michelson

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002531

The miR-35-41 Family of MicroRNAs Regulates RNAi Sensitivity in Caenorhabditis elegans

Katlin B. Massirer, Saida G. Perez, Vanessa Mondol, Amy E. Pasquinelli

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002536

Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes

Xiaoyun Wu, Zhen Shi, Mingxue Cui, Min Han, Gary Ruvkun

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002542

Exploring the Complexity of the HIV-1 Fitness Landscape

Roger D. Kouyos, Gabriel E. Leventhal, Trevor Hinkley, Mojgan Haddad, Jeannette M. Whitcomb, Christos J. Petropoulos, Sebastian Bonhoeffer

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002551

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

Décio L. Eizirik, Michael Sammeth, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo-Esteve, Fernanda Ortis, Izortze Santin, Maikel L. Colli, Jenny Barthson, Luc Bouwens, Linda Hughes, Lorna Gregory, Gerton Lunter, Lorella Marselli, Piero Marchetti, Mark I. McCarthy, Miriam Cnop

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002552

Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas

Joshua Mark Galanter, Juan Carlos Fernandez-Lopez, Christopher R. Gignoux, Jill Barnholtz-Sloan, Ceres Fernandez-Rozadilla, Marc Via, Alfredo Hidalgo-Miranda, Alejandra V. Contreras, Laura Uribe Figueroa, Paola Raska, Gerardo Jimenez-Sanchez, Irma Silva Zolezzi, Maria Torres, Clara Ruiz Ponte, Yarimar Ruiz, Antonio Salas, Elizabeth Nguyen, Celeste Eng, Lisbeth Borjas, William Zabala, Guillermo Barreto, Fernando Rondón González, Adriana Ibarra, Patricia Taboada, Liliana Porras, Fabián Moreno, Abigail Bigham, Gerardo Gutierrez, Tom Brutsaert, Fabiola León-Velarde, Lorna G. Moore, Enrique Vargas, Miguel Cruz, Jorge Escobedo, José Rodriguez-Santana, William Rodriguez-Cintrón, Rocio Chapela, Jean G. Ford, Carlos Bustamante, Daniela Seminara, Mark Shriver, Elad Ziv, Esteban Gonzalez Burchard, Robert Haile, Esteban Parra, Angel Carracedo, for the LACE Consortium

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002554

Networks of Neuronal Genes Affected by Common and Rare Variants in Autism Spectrum Disorders

Eyal Ben-David, Sagiv Shifman

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002556

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

Eimear E. Kenny, Itsik Pe'er, Amir Karban, Laurie Ozelius, Adele A. Mitchell, Sok Meng Ng, Monica Erazo, Harry Ostrer, Clara Abraham, Maria T. Abreu, Gil Atzmon, Nir Barzilai, Steven R. Brant, Susan Bressman, Edward R. Burns, Yehuda Chowers, Lorraine N. Clark, Ariel Darvasi, Dana Doheny, Richard H. Duerr, Rami Eliakim, Nir Giladi, Peter K. Gregersen, Hakon Hakonarson, Michelle R. Jones, Karen Marder, Dermot P. B. McGovern, Jennifer Mulle, Avi Orr-Urtreger, Deborah D. Proctor, Ann Pulver, Jerome I. Rotter, Mark S. Silverberg, Thomas Ullman, Stephen T. Warren, Matti Waterman, Wei Zhang, Aviv Bergman, Lloyd Mayer, Seymour Katz, Robert J. Desnick, Judy H. Cho, Inga Peter

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002559

Error-Prone ZW Pairing and No Evidence for Meiotic Sex Chromosome Inactivation in the Chicken Germ Line

Silvana Guioli, Robin Lovell-Badge, James M. A. Turner

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002560

Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line

Jia Qian Wu, Montrell Seay, Vincent P. Schulz, Manoj Hariharan, David Tuck, Jin Lian, Jiang Du, Minyi Shi, Zhijia Ye, Mark Gerstein, Michael P. Snyder, Sherman Weissman

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002565

Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators

Jessica L. McLellan, Nigel J. O'Neil, Irene Barrett, Elizabeth Ferree, Derek M. van Pel, Kevin Ushey, Payal Sipahimalani, Jennifer Bryan, Ann M. Rose, Philip Hieter

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002574

Spo0A∼P Imposes a Temporal Gate for the Bimodal Expression of Competence in Bacillus subtilis

Nicolas Mirouze, Yaanik Desai, Arjun Raj, David Dubnau

PLOS Genetics: published March 8, 2012 | https://doi.org/10.1371/journal.pgen.1002586

REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

Nikolaj Dietrich, Mads Lerdrup, Eskild Landt, Shuchi Agrawal-Singh, Mads Bak, Niels Tommerup, Juri Rappsilber, Erik Södersten, Klaus Hansen

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002494

Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in Caenorhabditis elegans

Daniel Ackerman, David Gems

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002498

Genomic Tools for Evolution and Conservation in the Chimpanzee: Pan troglodytes ellioti Is a Genetically Distinct Population

Rory Bowden, Tammie S. MacFie, Simon Myers, Garrett Hellenthal, Eric Nerrienet, Ronald E. Bontrop, Colin Freeman, Peter Donnelly, Nicholas I. Mundy

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002504

MNS1 Is Essential for Spermiogenesis and Motile Ciliary Functions in Mice

Jian Zhou, Fang Yang, N. Adrian Leu, P. Jeremy Wang

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002516

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

Song Liu, Tomoyo Sawada, Seongsoo Lee, Wendou Yu, George Silverio, Philomena Alapatt, Ivan Millan, Alice Shen, William Saxton, Tomoko Kanao, Ryosuke Takahashi, Nobutaka Hattori, Yuzuru Imai, Bingwei Lu

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002537

Rapid Analysis of Saccharomyces cerevisiae Genome Rearrangements by Multiplex Ligation–Dependent Probe Amplification

Jason E. Chan, Richard D. Kolodner

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002539

A Downstream CpG Island Controls Transcript Initiation and Elongation and the Methylation State of the Imprinted Airn Macro ncRNA Promoter

Martha V. Koerner, Florian M. Pauler, Quanah J. Hudson, Federica Santoro, Anna Sawicka, Philipp M. Guenzl, Stefan H. Stricker, Yvonne M. Schichl, Paulina A. Latos, Ruth M. Klement, Katarzyna E. Warczok, Jacek Wojciechowski, Christian Seiser, Robert Kralovics, Denise P. Barlow

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002540

A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1

Yuji Urabe, Chizu Tanikawa, Atsushi Takahashi, Yukinori Okada, Takashi Morizono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kenjiro Kohri, Kazuaki Chayama, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda

PLOS Genetics: published March 1, 2012 | https://doi.org/10.1371/journal.pgen.1002541

March 2012

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