Svoboda | Graniru | BBC Russia | Golosameriki | Facebook
Skip to main content
Advertisement
Table of Contents

September 2013

Flowers of the selfing plant species, C. rubella. In this issue, Brandvain et al. identify blocks of ancestry inherited from the founders of this recently derived species. With these blocks, they learn that C. rubella split from its outcrossing progenitor around 50 to 100,000 years ago, and subsequently lost much of its genetic diversity. These ancestry blocks also inform us about the number of individuals that founded C. rubella, the relaxation of purifying selection since its origin, and its spread across the globe.

Image Credit: Kim Steige

Interview

Research Articles

Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A

Yuri M. Moshkin, Cecile M. Doyen, Tsung-Wai Kan, Gillian E. Chalkley, Karen Sap, Karel Bezstarosti, Jeroen A. Demmers, Zeliha Ozgur, Wilfred F. J. van Ijcken, C. Peter Verrijzer

Related Articles

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection

Nicholas Renzette, Laura Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, Timothy F. Kowalik

IL-17 Attenuates Degradation of ARE-mRNAs by Changing the Cooperation between AU-Binding Proteins and microRNA16

Saheli Chowdhury, Annemiek Dijkhuis, Sabrina Steiert, René Lutter

Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila

David S. Garbe, Yanshan Fang, Xiangzhong Zheng, Mallory Sowcik, Rana Anjum, Steven P. Gygi, Amita Sehgal

Meiotic Recombination in Arabidopsis Is Catalysed by DMC1, with RAD51 Playing a Supporting Role

Olivier Da Ines, Fabienne Degroote, Chantal Goubely, Simon Amiard, Maria E. Gallego, Charles I. White

Genome-Wide Analysis of ZmDREB Genes and Their Association with Natural Variation in Drought Tolerance at Seedling Stage of Zea mays L

Shengxue Liu, Xianglan Wang, Hongwei Wang, Haibo Xin, Xiaohong Yang, Jianbing Yan, Jiansheng Li, Lam-Son Phan Tran, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki, Feng Qin

Fusion of Large-Scale Genomic Knowledge and Frequency Data Computationally Prioritizes Variants in Epilepsy

Ian M. Campbell, Mitchell Rao, Sean D. Arredondo, Seema R. Lalani, Zhilian Xia, Sung-Hae L. Kang, Weimin Bi, Amy M. Breman, Janice L. Smith, Carlos A. Bacino, Arthur L. Beaudet, Ankita Patel, Sau Wai Cheung, James R. Lupski, Paweł Stankiewicz, Melissa B. Ramocki, Chad A. Shaw

The Highly Prolific Phenotype of Lacaune Sheep Is Associated with an Ectopic Expression of the B4GALNT2 Gene within the Ovary

Laurence Drouilhet, Camille Mansanet, Julien Sarry, Kamila Tabet, Philippe Bardou, Florent Woloszyn, Jérome Lluch, Grégoire Harichaux, Catherine Viguié, Danielle Monniaux, Loys Bodin, Philippe Mulsant, Stéphane Fabre

Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3

Daniel W. Sirkis, Robert H. Edwards, Cédric S. Asensio

Whole-Exome Sequencing Reveals a Rapid Change in the Frequency of Rare Functional Variants in a Founding Population of Humans

Ferran Casals, Alan Hodgkinson, Julie Hussin, Youssef Idaghdour, Vanessa Bruat, Thibault de Maillard, Jean-Cristophe Grenier, Elias Gbeha, Fadi F. Hamdan, Simon Girard, Jean-François Spinella, Mathieu Larivière, Virginie Saillour, Jasmine Healy, Isabel Fernández, Daniel Sinnett, Jacques L. Michaud, Guy A. Rouleau, Elie Haddad, Françoise Le Deist, Philip Awadalla

Related Articles

Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease

Albino Bacolla, Nuri A. Temiz, Ming Yi, Joseph Ivanic, Regina Z. Cer, Duncan E. Donohue, Edward V. Ball, Uma S. Mudunuri, Guliang Wang, Aklank Jain, Natalia Volfovsky, Brian T. Luke, Robert M. Stephens, David N. Cooper, Jack R. Collins, Karen M. Vasquez

Natural Genetic Transformation Generates a Population of Merodiploids in Streptococcus pneumoniae

Calum Johnston, Stéphanie Caymaris, Aldert Zomer, Hester J. Bootsma, Marc Prudhomme, Chantal Granadel, Peter W. M. Hermans, Patrice Polard, Bernard Martin, Jean-Pierre Claverys

In Vivo Analysis of Lrig Genes Reveals Redundant and Independent Functions in the Inner Ear

Tony del Rio, Allison M. Nishitani, Wei-Ming Yu, Lisa V. Goodrich

Manipulating or Superseding Host Recombination Functions: A Dilemma That Shapes Phage Evolvability

Louis-Marie Bobay, Marie Touchon, Eduardo P. C. Rocha

Binding of NF-κB to Nucleosomes: Effect of Translational Positioning, Nucleosome Remodeling and Linker Histone H1

Imtiaz Nisar Lone, Manu Shubhdarshan Shukla, John Lalith Charles Richard, Zahary Yordanov Peshev, Stefan Dimitrov, Dimitar Angelov

The Molecular Chaperone Hsp90 Is Required for Cell Cycle Exit in Drosophila melanogaster

Jennifer L. Bandura, Huaqi Jiang, Derek W. Nickerson, Bruce A. Edgar

Dealing with the Evolutionary Downside of CRISPR Immunity: Bacteria and Beneficial Plasmids

Wenyan Jiang, Inbal Maniv, Fawaz Arain, Yaying Wang, Bruce R. Levin, Luciano A. Marraffini

A Shift to Organismal Stress Resistance in Programmed Cell Death Mutants

Meredith E. Judy, Ayumi Nakamura, Anne Huang, Harli Grant, Helen McCurdy, Kurt F. Weiberth, Fuying Gao, Giovanni Coppola, Cynthia Kenyon, Aimee W. Kao

Recent Acquisition of Helicobacter pylori by Baka Pygmies

Sandra Nell, Daniel Eibach, Valeria Montano, Ayas Maady, Armand Nkwescheu, Jose Siri, Wael F. Elamin, Daniel Falush, Bodo Linz, Mark Achtman, Yoshan Moodley, Sebastian Suerbaum

The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation

Gonzalo Millán-Zambrano, Alfonso Rodríguez-Gil, Xenia Peñate, Lola de Miguel-Jiménez, Macarena Morillo-Huesca, Nevan Krogan, Sebastián Chávez

MEIOB Targets Single-Strand DNA and Is Necessary for Meiotic Recombination

Benoit Souquet, Emilie Abby, Roxane Hervé, Friederike Finsterbusch, Sophie Tourpin, Ronan Le Bouffant, Clotilde Duquenne, Sébastien Messiaen, Emmanuelle Martini, Jacqueline Bernardino-Sgherri, Attila Toth, René Habert, Gabriel Livera

MicroRNA-17-92, a Direct Ap-2α Transcriptional Target, Modulates T-Box Factor Activity in Orofacial Clefting

Jun Wang, Yan Bai, Hong Li, Stephanie B. Greene, Elzbieta Klysik, Wei Yu, Robert J. Schwartz, Trevor J. Williams, James F. Martin

Related Articles

System-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity

Megha Rajaram, Jinyu Li, Mikala Egeblad, R. Scott Powers

miR-1/133a Clusters Cooperatively Specify the Cardiomyogenic Lineage by Adjustment of Myocardin Levels during Embryonic Heart Development

Katharina Wystub, Johannes Besser, Angela Bachmann, Thomas Boettger, Thomas Braun

Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

Conall M. O'Seaghdha, Hongsheng Wu, Qiong Yang, Karen Kapur, Idris Guessous, Annie Mercier Zuber, Anna Köttgen, Candice Stoudmann, Alexander Teumer, Zoltán Kutalik, Massimo Mangino, Abbas Dehghan, Weihua Zhang, Gudny Eiriksdottir, Guo Li, Toshiko Tanaka, Laura Portas, Lorna M. Lopez, Caroline Hayward, Kurt Lohman, Koichi Matsuda, Sandosh Padmanabhan, Dmitri Firsov, Rossella Sorice, Sheila Ulivi, A. Catharina Brockhaus, Marcus E. Kleber, Anubha Mahajan, Florian D. Ernst, Vilmundur Gudnason, Lenore J. Launer, Aurelien Mace, Eric Boerwinckle, Dan E. Arking, Chizu Tanikawa, Yusuke Nakamura, Morris J. Brown, Jean-Michel Gaspoz, Jean-Marc Theler, David S. Siscovick, Bruce M. Psaty, Sven Bergmann, Peter Vollenweider, Veronique Vitart, Alan F. Wright, Tatijana Zemunik, Mladen Boban, Ivana Kolcic, Pau Navarro, Edward M. Brown, Karol Estrada, Jingzhong Ding, Tamara B. Harris, Stefania Bandinelli, Dena Hernandez, Andrew B. Singleton, Giorgia Girotto, Daniela Ruggiero, Adamo Pio d'Adamo, Antonietta Robino, Thomas Meitinger, Christa Meisinger, Gail Davies, John M. Starr, John C. Chambers, Bernhard O. Boehm, Bernhard R. Winkelmann, Jie Huang, Federico Murgia, Sarah H. Wild, Harry Campbell, Andrew P. Morris, Oscar H. Franco, Albert Hofman, Andre G. Uitterlinden, Fernando Rivadeneira, Uwe Völker, Anke Hannemann, Reiner Biffar, Wolfgang Hoffmann, So–Youn Shin, Pierre Lescuyer, Hughes Henry, Claudia Schurmann, The SUNLIGHT consortium, The GEFOS consortium, Patricia B. Munroe, Paolo Gasparini, Nicola Pirastu, Marina Ciullo, Christian Gieger, Winfried März, Lars Lind, Tim D. Spector, Albert V. Smith, Igor Rudan, James F. Wilson, Ozren Polasek, Ian J. Deary, Mario Pirastu, Luigi Ferrucci, Yongmei Liu, Bryan Kestenbaum, Jaspal S. Kooner, Jacqueline C. M. Witteman, Matthias Nauck, W. H. Linda Kao, Henri Wallaschofski, Olivier Bonny, Caroline S. Fox, Murielle Bochud

Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis

Priit Jõers, Samantha C. Lewis, Atsushi Fukuoh, Mikael Parhiala, Simo Ellilä, Ian J. Holt, Howard T. Jacobs

Tracking of Chromosome and Replisome Dynamics in Myxococcus xanthus Reveals a Novel Chromosome Arrangement

Andrea Harms, Anke Treuner-Lange, Dominik Schumacher, Lotte Søgaard-Andersen

Genotype-Environment Interactions Reveal Causal Pathways That Mediate Genetic Effects on Phenotype

Julien Gagneur, Oliver Stegle, Chenchen Zhu, Petra Jakob, Manu M. Tekkedil, Raeka S. Aiyar, Ann-Kathrin Schuon, Dana Pe'er, Lars M. Steinmetz

N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing

Vassia Schiza, Diego Molina-Serrano, Dimitris Kyriakou, Antonia Hadjiantoniou, Antonis Kirmizis

Predicting the Risk of Rheumatoid Arthritis and Its Age of Onset through Modelling Genetic Risk Variants with Smoking

Ian C. Scott, Seth D. Seegobin, Sophia Steer, Rachael Tan, Paola Forabosco, Anne Hinks, Stephen Eyre, Ann W. Morgan, Anthony G. Wilson, Lynne J. Hocking, Paul Wordsworth, Anne Barton, Jane Worthington, Andrew P. Cope, Cathryn M. Lewis

Related Articles

Phenotypic and Genetic Consequences of Protein Damage

Anita Krisko, Miroslav Radman

The Molecular Mechanism of a Cis-Regulatory Adaptation in Yeast

Jessica Chang, Yiqi Zhou, Xiaoli Hu, Lucia Lam, Cameron Henry, Erin M. Green, Ryosuke Kita, Michael S. Kobor, Hunter B. Fraser

dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia

Jina Park, Jeongmi Lee, Jaewon Shim, Woongsu Han, Jinu Lee, Yong Chul Bae, Yun Doo Chung, Chul Hoon Kim, Seok Jun Moon

The Genome and Development-Dependent Transcriptomes of Pyronema confluens: A Window into Fungal Evolution

Stefanie Traeger, Florian Altegoer, Michael Freitag, Toni Gabaldon, Frank Kempken, Abhishek Kumar, Marina Marcet-Houben, Stefanie Pöggeler, Jason E. Stajich, Minou Nowrousian

Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors

James D. Phelan, Ingrid Saba, Hui Zeng, Christian Kosan, Malynda S. Messer, H. Andre Olsson, Jennifer Fraszczak, David A. Hildeman, Bruce J. Aronow, Tarik Möröy, H. Leighton Grimes

The hedgehog Pathway Gene shifted Functions together with the hmgcr-Dependent Isoprenoid Biosynthetic Pathway to Orchestrate Germ Cell Migration

Girish Deshpande, Keren Zhou, Joy Y. Wan, Jana Friedrich, Nicholas Jourjine, Daniel Smith, Paul Schedl

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

Mélissa Beaudoin, Philippe Goyette, Gabrielle Boucher, Ken Sin Lo, Manuel A. Rivas, Christine Stevens, Azadeh Alikashani, Martin Ladouceur, David Ellinghaus, Leif Törkvist, Gautam Goel, Caroline Lagacé, Vito Annese, Alain Bitton, Jakob Begun, Steve R. Brant, Francesca Bresso, Judy H. Cho, Richard H. Duerr, Jonas Halfvarson, Dermot P. B. McGovern, Graham Radford-Smith, Stefan Schreiber, Philip L. Schumm, Yashoda Sharma, Mark S. Silverberg, Rinse K. Weersma, Quebec IBD Genetics Consortium, NIDDK IBD Genetics Consortium, International IBD Genetics Consortium, Mauro D'Amato, Severine Vermeire, Andre Franke, Guillaume Lettre, Ramnik J. Xavier, Mark J. Daly, John D. Rioux

Extensive Divergence of Transcription Factor Binding in Drosophila Embryos with Highly Conserved Gene Expression

Mathilde Paris, Tommy Kaplan, Xiao Yong Li, Jacqueline E. Villalta, Susan E. Lott, Michael B. Eisen

Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill

William M. Brandler, Andrew P. Morris, David M. Evans, Thomas S. Scerri, John P. Kemp, Nicholas J. Timpson, Beate St Pourcain, George Davey Smith, Susan M. Ring, John Stein, Anthony P. Monaco, Joel B. Talcott, Simon E. Fisher, Caleb Webber, Silvia Paracchini

Genomic Identification of Founding Haplotypes Reveals the History of the Selfing Species Capsella rubella

Yaniv Brandvain, Tanja Slotte, Khaled M. Hazzouri, Stephen I. Wright, Graham Coop

An Atypical Kinase under Balancing Selection Confers Broad-Spectrum Disease Resistance in Arabidopsis

Carine Huard-Chauveau, Laure Perchepied, Marilyne Debieu, Susana Rivas, Thomas Kroj, Ilona Kars, Joy Bergelson, Fabrice Roux, Dominique Roby

Regulation of the Boundaries of Accessible Chromatin

Xiaoran Chai, Sanjanaa Nagarajan, Kwoneel Kim, Kibaick Lee, Jung Kyoon Choi

A Pre-mRNA-Splicing Factor Is Required for RNA-Directed DNA Methylation in Arabidopsis

Chao-Feng Huang, Daisuke Miki, Kai Tang, Hao-Ran Zhou, Zhimin Zheng, Wei Chen, Ze-Yang Ma, Lan Yang, Heng Zhang, Renyi Liu, Xin-Jian He, Jian-Kang Zhu

Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites

Sarah D. Diermeier, Attila Németh, Michael Rehli, Ingrid Grummt, Gernot Längst

The Condition-Dependent Transcriptional Landscape of Burkholderia pseudomallei

Wen Fong Ooi, Catherine Ong, Tannistha Nandi, Jason F. Kreisberg, Hui Hoon Chua, Guangwen Sun, Yahua Chen, Claudia Mueller, Laura Conejero, Majid Eshaghi, Roy Moh Lik Ang, Jianhua Liu, Bruno W. Sobral, Sunee Korbsrisate, Yunn Hwen Gan, Richard W. Titball, Gregory J. Bancroft, Eric Valade, Patrick Tan

A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast

Timothy Hoggard, Erika Shor, Carolin A. Müller, Conrad A. Nieduszynski, Catherine A. Fox

PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C. elegans

Emma Svensk, Marcus Ståhlman, Carl-Henrik Andersson, Maja Johansson, Jan Borén, Marc Pilon

Genetic and Anatomical Basis of the Barrier Separating Wakefulness and Anesthetic-Induced Unresponsiveness

William J. Joiner, Eliot B. Friedman, Hsiao-Tung Hung, Kyunghee Koh, Mallory Sowcik, Amita Sehgal, Max B. Kelz

Related Articles

Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic Model

James O. Groves, Isla Leslie, Guo-Jen Huang, Stephen B. McHugh, Amy Taylor, Richard Mott, Marcus Munafò, David M. Bannerman, Jonathan Flint

Environmental Stresses Disrupt Telomere Length Homeostasis

Gal Hagit Romano, Yaniv Harari, Tal Yehuda, Ariel Podhorzer, Linda Rubinstein, Ron Shamir, Assaf Gottlieb, Yael Silberberg, Dana Pe'er, Eytan Ruppin, Roded Sharan, Martin Kupiec

Genome-Wide Mutation Avalanches Induced in Diploid Yeast Cells by a Base Analog or an APOBEC Deaminase

Artem G. Lada, Elena I. Stepchenkova, Irina S. R. Waisertreiger, Vladimir N. Noskov, Alok Dhar, James D. Eudy, Robert J. Boissy, Masayuki Hirano, Igor B. Rogozin, Youri I. Pavlov

VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans

Sung Min Han, Hajer El Oussini, Jelena Scekic-Zahirovic, Jack Vibbert, Pauline Cottee, Jeevan K. Prasain, Hugo J. Bellen, Luc Dupuis, Michael A. Miller

Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

Edze R. Westra, Ekaterina Semenova, Kirill A. Datsenko, Ryan N. Jackson, Blake Wiedenheft, Konstantin Severinov, Stan J. J. Brouns

Bi-modal Distribution of the Second Messenger c-di-GMP Controls Cell Fate and Asymmetry during the Caulobacter Cell Cycle

Sören Abel, Tabitha Bucher, Micaël Nicollier, Isabelle Hug, Volkhard Kaever, Pia Abel zur Wiesch, Urs Jenal

An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression

Shaofeng Wang, Feng Wen, Graham B. Wiley, Michael T. Kinter, Patrick M. Gaffney

Stochastic Loss of Silencing of the Imprinted Ndn/NDN Allele, in a Mouse Model and Humans with Prader-Willi Syndrome, Has Functional Consequences

Anne Rieusset, Fabienne Schaller, Unga Unmehopa, Valery Matarazzo, Françoise Watrin, Matthias Linke, Beatrice Georges, Jocelyn Bischof, Femke Dijkstra, Monique Bloemsma, Severine Corby, François J. Michel, Rachel Wevrick, Ulrich Zechner, Dick Swaab, Keith Dudley, Laurent Bezin, Françoise Muscatelli

Divergent Transcriptional Regulatory Logic at the Intersection of Tissue Growth and Developmental Patterning

Matthew Slattery, Roumen Voutev, Lijia Ma, Nicolas Nègre, Kevin P. White, Richard S. Mann

Functional Dissection of Regulatory Models Using Gene Expression Data of Deletion Mutants

Jin'e Li, Yi Liu, Min Liu, Jing-Dong J. Han

The Arabidopsis IDD14, IDD15, and IDD16 Cooperatively Regulate Lateral Organ Morphogenesis and Gravitropism by Promoting Auxin Biosynthesis and Transport

Dayong Cui, Jingbo Zhao, Yanjun Jing, Mingzhu Fan, Jing Liu, Zhicai Wang, Wei Xin, Yuxin Hu

Plasticity Regulators Modulate Specific Root Traits in Discrete Nitrogen Environments

Miriam L. Gifford, Joshua A. Banta, Manpreet S. Katari, Jo Hulsmans, Lisa Chen, Daniela Ristova, Daniel Tranchina, Michael D. Purugganan, Gloria M. Coruzzi, Kenneth D. Birnbaum

Convergent Transcription Induces Dynamic DNA Methylation at disiRNA Loci

Yunkun Dang, Liande Li, Wei Guo, Zhihong Xue, Yi Liu

Dynamics of DNA Methylation in Recent Human and Great Ape Evolution

Irene Hernando-Herraez, Javier Prado-Martinez, Paras Garg, Marcos Fernandez-Callejo, Holger Heyn, Christina Hvilsom, Arcadi Navarro, Manel Esteller, Andrew J. Sharp, Tomas Marques-Bonet

Transmission of Hypervirulence Traits via Sexual Reproduction within and between Lineages of the Human Fungal Pathogen Cryptococcus gattii

Kerstin Voelz, Hansong Ma, Sujal Phadke, Edmond J. Byrnes, Pinkuan Zhu, Olaf Mueller, Rhys A. Farrer, Daniel A. Henk, Yonathan Lewit, Yen-Ping Hsueh, Matthew C. Fisher, Alexander Idnurm, Joseph Heitman, Robin C. May

Cell Interactions and Patterned Intercalations Shape and Link Epithelial Tubes in C. elegans

Jeffrey P. Rasmussen, Jessica L. Feldman, Sowmya Somashekar Reddy, James R. Priess

An Alteration in ELMOD3, an Arl2 GTPase-Activating Protein, Is Associated with Hearing Impairment in Humans

Thomas J. Jaworek, Elodie M. Richard, Anna A. Ivanova, Arnaud P. J. Giese, Daniel I. Choo, Shaheen N. Khan, Sheikh Riazuddin, Richard A. Kahn, Saima Riazuddin

Cell-Type Specific Features of Circular RNA Expression

Julia Salzman, Raymond E. Chen, Mari N. Olsen, Peter L. Wang, Patrick O. Brown

Related Articles

Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model

Mimi Cushman-Nick, Nancy M. Bonini, James Shorter