Dogs are not only “man's best friend” for their loyalty, they are also the geneticist’s best friend. The artificial breed structure has created genetically isolated groups of dogs, with differential predisposition to diseases they share with us. This facilitates mapping of diseases relevant also to humans. Golden retrievers are predisposed to various cancers, including B-cell lymphoma and hemangiosarcoma. The genetic risk factors for these diseases in humans are still being elucidated. Surprisingly, golden retrievers have two nearby genetic loci with haplotypes predisposing to both diseases. See Tonomura et al.
Image Credit: Mike Lappin
Editorial
PLOS Genetics 2014 Reviewer Thank You
PLOS Genetics: published February 27, 2015 | https://doi.org/10.1371/journal.pgen.1005070
Perspective
R2d2 and Hyperdrive Mechanisms (in Mouse Meiosis)
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004950
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Review
Closing the Gap between Knowledge and Clinical Application: Challenges for Genomic Translation
PLOS Genetics: published February 26, 2015 | https://doi.org/10.1371/journal.pgen.1004978
Research Articles
Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
PLOS Genetics: published February 27, 2015 | https://doi.org/10.1371/journal.pgen.1004987
Prodomain Removal Enables Neto to Stabilize Glutamate Receptors at the Drosophila Neuromuscular Junction
PLOS Genetics: published February 27, 2015 | https://doi.org/10.1371/journal.pgen.1004988
Region-Specific Activation of oskar mRNA Translation by Inhibition of Bruno-Mediated Repression
PLOS Genetics: published February 27, 2015 | https://doi.org/10.1371/journal.pgen.1004992
Mutations in MAB21L2 Result in Ocular Coloboma, Microcornea and Cataracts
PLOS Genetics: published February 26, 2015 | https://doi.org/10.1371/journal.pgen.1005002
An Essential Role of the Arginine Vasotocin System in Mate-Guarding Behaviors in Triadic Relationships of Medaka Fish (Oryzias latipes)
PLOS Genetics: published February 26, 2015 | https://doi.org/10.1371/journal.pgen.1005009
Transhydrogenase Promotes the Robustness and Evolvability of E. coli Deficient in NADPH Production
PLOS Genetics: published February 25, 2015 | https://doi.org/10.1371/journal.pgen.1005007
microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes
PLOS Genetics: published February 25, 2015 | https://doi.org/10.1371/journal.pgen.1005020
acal is a Long Non-coding RNA in JNK Signaling in Epithelial Shape Changes during Drosophila Dorsal Closure
PLOS Genetics: published February 24, 2015 | https://doi.org/10.1371/journal.pgen.1004927
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Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis
PLOS Genetics: published February 23, 2015 | https://doi.org/10.1371/journal.pgen.1004990
Recent Selective Sweeps in North American Drosophila melanogaster Show Signatures of Soft Sweeps
PLOS Genetics: published February 23, 2015 | https://doi.org/10.1371/journal.pgen.1005004
Recurrent Evolution of Melanism in South American Felids
PLOS Genetics: published February 19, 2015 | https://doi.org/10.1371/journal.pgen.1004892
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Eye Selector Logic for a Coordinated Cell Cycle Exit
PLOS Genetics: published February 19, 2015 | https://doi.org/10.1371/journal.pgen.1004981
Matrix Metalloproteinase 2 Is Required for Ovulation and Corpus Luteum Formation in Drosophila
PLOS Genetics: published February 19, 2015 | https://doi.org/10.1371/journal.pgen.1004989
Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo
PLOS Genetics: published February 19, 2015 | https://doi.org/10.1371/journal.pgen.1004991
Essential Role for Endogenous siRNAs during Meiosis in Mouse Oocytes
PLOS Genetics: published February 19, 2015 | https://doi.org/10.1371/journal.pgen.1005013
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Systemic Delivery of MicroRNA-101 Potently Inhibits Hepatocellular Carcinoma In Vivo by Repressing Multiple Targets
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1004873
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The Arabidopsis DNA Polymerase δ Has a Role in the Deposition of Transcriptionally Active Epigenetic Marks, Development and Flowering
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1004975
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A Rolling Circle Replication Mechanism Produces Multimeric Lariats of Mitochondrial DNA in Caenorhabditis elegans
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1004985
A Genome-Wide Hybrid Incompatibility Landscape between Caenorhabditis briggsae and C. nigoni
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1004993
Fatty Acid Synthase Cooperates with Glyoxalase 1 to Protect against Sugar Toxicity
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1004995
An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1004996
Regulators of Autophagosome Formation in Drosophila Muscles
PLOS Genetics: published February 18, 2015 | https://doi.org/10.1371/journal.pgen.1005006
Genomic Selection and Association Mapping in Rice (Oryza sativa): Effect of Trait Genetic Architecture, Training Population Composition, Marker Number and Statistical Model on Accuracy of Rice Genomic Selection in Elite, Tropical Rice Breeding Lines
PLOS Genetics: published February 17, 2015 | https://doi.org/10.1371/journal.pgen.1004982
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A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004850
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HYPER RECOMBINATION1 of the THO/TREX Complex Plays a Role in Controlling Transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 Gene in Arabidopsis
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004956
Genomics of Divergence along a Continuum of Parapatric Population Differentiation
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004966
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Evolutionary Signatures amongst Disease Genes Permit Novel Methods for Gene Prioritization and Construction of Informative Gene-Based Networks
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004967
P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004971
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Discovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004994
The Exosome Component Rrp6 Is Required for RNA Polymerase II Termination at Specific Targets of the Nrd1-Nab3 Pathway
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1004999
Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1005000
Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1005008
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Sex-specific Trans-regulatory Variation on the Drosophila melanogaster X Chromosome
PLOS Genetics: published February 13, 2015 | https://doi.org/10.1371/journal.pgen.1005015
Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice
PLOS Genetics: published February 12, 2015 | https://doi.org/10.1371/journal.pgen.1004964
Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus
PLOS Genetics: published February 12, 2015 | https://doi.org/10.1371/journal.pgen.1004974
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Combining Natural Sequence Variation with High Throughput Mutational Data to Reveal Protein Interaction Sites
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004918
Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004935
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Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004955
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African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004960
Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004972
Antagonistic Roles for KNOX1 and KNOX2 Genes in Patterning the Land Plant Body Plan Following an Ancient Gene Duplication
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004980
Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans
PLOS Genetics: published February 11, 2015 | https://doi.org/10.1371/journal.pgen.1004997
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Tribolium castaneum RR-1 Cuticular Protein TcCPR4 Is Required for Formation of Pore Canals in Rigid Cuticle
PLOS Genetics: published February 9, 2015 | https://doi.org/10.1371/journal.pgen.1004963
A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1004926
Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1004932
Asymmetry of the Budding Yeast Tem1 GTPase at Spindle Poles Is Required for Spindle Positioning But Not for Mitotic Exit
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1004938
GC-Content Evolution in Bacterial Genomes: The Biased Gene Conversion Hypothesis Expands
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1004941
Modeling of the Human Alveolar Rhabdomyosarcoma Pax3-Foxo1 Chromosome Translocation in Mouse Myoblasts Using CRISPR-Cas9 Nuclease
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1004951
K-homology Nuclear Ribonucleoproteins Regulate Floral Organ Identity and Determinacy in Arabidopsis
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1004983
Discovery of CTCF-Sensitive Cis-Spliced Fusion RNAs between Adjacent Genes in Human Prostate Cells
PLOS Genetics: published February 6, 2015 | https://doi.org/10.1371/journal.pgen.1005001
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The Genetic Architecture of the Genome-Wide Transcriptional Response to ER Stress in the Mouse
PLOS Genetics: published February 4, 2015 | https://doi.org/10.1371/journal.pgen.1004924
Abscission Is Regulated by the ESCRT-III Protein Shrub in Drosophila Germline Stem Cells
PLOS Genetics: published February 3, 2015 | https://doi.org/10.1371/journal.pgen.1004653
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Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction
PLOS Genetics: published February 3, 2015 | https://doi.org/10.1371/journal.pgen.1004855
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Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
PLOS Genetics: published February 3, 2015 | https://doi.org/10.1371/journal.pgen.1004901
Membrane Recognition and Dynamics of the RNA Degradosome
PLOS Genetics: published February 3, 2015 | https://doi.org/10.1371/journal.pgen.1004961
Identification and Functional Analysis of Healing Regulators in Drosophila
PLOS Genetics: published February 3, 2015 | https://doi.org/10.1371/journal.pgen.1004965
Structured Observations Reveal Slow HIV-1 CTL Escape
PLOS Genetics: published February 2, 2015 | https://doi.org/10.1371/journal.pgen.1004914
Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
PLOS Genetics: published February 2, 2015 | https://doi.org/10.1371/journal.pgen.1004922
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A Nitric Oxide Regulated Small RNA Controls Expression of Genes Involved in Redox Homeostasis in Bacillus subtilis
PLOS Genetics: published February 2, 2015 | https://doi.org/10.1371/journal.pgen.1004957
The Hippo Pathway Regulates Homeostatic Growth of Stem Cell Niche Precursors in the Drosophila Ovary
PLOS Genetics: published February 2, 2015 | https://doi.org/10.1371/journal.pgen.1004962
Drosophila Casein Kinase I Alpha Regulates Homolog Pairing and Genome Organization by Modulating Condensin II Subunit Cap-H2 Levels
PLOS Genetics: published February 27, 2015 | https://doi.org/10.1371/journal.pgen.1005014
Temperature Stress Mediates Decanalization and Dominance of Gene Expression in Drosophila melanogaster
PLOS Genetics: published February 26, 2015 | https://doi.org/10.1371/journal.pgen.1004883