Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Kinrin Yamanaka, Nimrat Chatterjee, Michael T. Hemann, Graham C. Walker

PLOS Genetics: published August 17, 2017 | https://doi.org/10.1371/journal.pgen.1006842

PRRG4 function reveals that Robo trafficking is evolutionarily conserved

Jimena Berni

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006927

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Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases

Mahekta R. Gujar, Aubrie M. Stricker, Erik A. Lundquist

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006998

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development

Hua He, Meina Huang, Shenfei Sun, Yihui Wu, Xinhua Lin

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006992

MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus

Patricia Blanchet, Martina Bebin, Shaam Bruet, Gregory M. Cooper, Michelle L. Thompson, Benedicte Duban-Bedu, Benedicte Gerard, Amelie Piton, Sylvie Suckno, Charu Deshpande, Virginia Clowes, Julie Vogt, Peter Turnpenny, Michael P. Williamson, Yves Alembik, Clinical Sequencing Exploratory Research Study Consortium, Deciphering Developmental Disorders Consortium, Eric Glasgow, Alisdair McNeill

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006957

Plant microRNAs in larval food regulate honeybee caste development

Kegan Zhu, Minghui Liu, Zheng Fu, Zhen Zhou, Yan Kong, Hongwei Liang, Zheguang Lin, Jun Luo, Huoqing Zheng, Ping Wan, Junfeng Zhang, Ke Zen, Jiong Chen, Fuliang Hu, Chen-Yu Zhang, Jie Ren, Xi Chen

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006946

Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma

Edward Britton, Connor Rogerson, Shaveta Mehta, Yaoyong Li, Xiaodun Li, the OCCAMS consortium, Rebecca C. Fitzgerald, Yeng S. Ang, Andrew D. Sharrocks

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006879

The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene

Elizabeth D. Justice, Sarah J. Barnum, Thomas Kidd

PLOS Genetics: published August 31, 2017 | https://doi.org/10.1371/journal.pgen.1006865

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rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline

Devanshi Jain, Cem Meydan, Julian Lange, Corentin Claeys Bouuaert, Nathalie Lailler, Christopher E. Mason, Kathryn V. Anderson, Scott Keeney

PLOS Genetics: published August 30, 2017 | https://doi.org/10.1371/journal.pgen.1006964

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression

Ayako Fukunaka, Toshiyuki Fukada, Jinhyuk Bhin, Luka Suzuki, Takamasa Tsuzuki, Yuri Takamine, Bum-Ho Bin, Toshinori Yoshihara, Noriko Ichinoseki-Sekine, Hisashi Naito, Takeshi Miyatsuka, Shinzaburo Takamiya, Tsutomu Sasaki, Takeshi Inagaki, Tadahiro Kitamura, Shingo Kajimura, Hirotaka Watada, Yoshio Fujitani

PLOS Genetics: published August 30, 2017 | https://doi.org/10.1371/journal.pgen.1006950

β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice

Dany Gaillard, Spencer G. Bowles, Ernesto Salcedo, Mingang Xu, Sarah E. Millar, Linda A. Barlow

PLOS Genetics: published August 28, 2017 | https://doi.org/10.1371/journal.pgen.1006990

Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity

Suzana Ulian-Benitez, Simon Bishop, Istvan Foldi, Jill Wentzell, Chinenye Okenwa, Manuel G. Forero, Bangfu Zhu, Marta Moreira, Mark Phizacklea, Graham McIlroy, Guiyi Li, Nicholas J. Gay, Alicia Hidalgo

PLOS Genetics: published August 28, 2017 | https://doi.org/10.1371/journal.pgen.1006968

Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion

Laurits Skov, The Danish Pan Genome Consortium, Mikkel Heide Schierup

PLOS Genetics: published August 28, 2017 | https://doi.org/10.1371/journal.pgen.1006834

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart

Melisa Gomez-Velazquez, Claudio Badia-Careaga, Ana Victoria Lechuga-Vieco, Rocio Nieto-Arellano, Juan J. Tena, Isabel Rollan, Alba Alvarez, Carlos Torroja, Eva F. Caceres, Anna R. Roy, Niels Galjart, Paul Delgado-Olguin, Fatima Sanchez-Cabo, Jose Antonio Enriquez, Jose Luis Gomez-Skarmeta, Miguel Manzanares

PLOS Genetics: published August 28, 2017 | https://doi.org/10.1371/journal.pgen.1006985

Functional significance of rare neuroligin 1 variants found in autism

Moe Nakanishi, Jun Nomura, Xiao Ji, Kota Tamada, Takashi Arai, Eiki Takahashi, Maja Bućan, Toru Takumi

PLOS Genetics: published August 25, 2017 | https://doi.org/10.1371/journal.pgen.1006940

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Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells

Uri Weissbein, Omer Plotnik, Dan Vershkov, Nissim Benvenisty

PLOS Genetics: published August 24, 2017 | https://doi.org/10.1371/journal.pgen.1006979

Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations

Nina Hollfelder, Carina M. Schlebusch, Torsten Günther, Hiba Babiker, Hisham Y. Hassan, Mattias Jakobsson

PLOS Genetics: published August 24, 2017 | https://doi.org/10.1371/journal.pgen.1006976

The activation of OsEIL1 on YUC8 transcription and auxin biosynthesis is required for ethylene-inhibited root elongation in rice early seedling development

Hua Qin, Zhijin Zhang, Juan Wang, Xinbing Chen, Pengcheng Wei, Rongfeng Huang

PLOS Genetics: published August 22, 2017 | https://doi.org/10.1371/journal.pgen.1006955

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP⁺-dependent isocitrate dehydrogenase (IDH)

Jinsung Yang, Min Ju Kim, Woongchang Yoon, Eun Young Kim, Hyunjin Kim, Yoonjeong Lee, Boram Min, Kyung Shin Kang, Jin H. Son, Hwan Tae Park, Jongkyeong Chung, Hyongjong Koh

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006975

Composite likelihood method for inferring local pedigrees

Amy Ko, Rasmus Nielsen

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006963

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity

Wern-Chir Liao, Liang-Yi Juo, Yen-Ling Shih, Yen-Hui Chen, Yu-Ting Yan

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006984

Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate

Irnov Irnov, Zhe Wang, Nicholas D. Jannetty, Julian A. Bustamante, Kyu Y. Rhee, Christine Jacobs-Wagner

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006978

mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide

Najla Al-Sweel, Vandana Raghavan, Abhishek Dutta, V. P. Ajith, Luigi Di Vietro, Nabila Khondakar, Carol M. Manhart, Jennifer A. Surtees, K. T. Nishant, Eric Alani

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006974

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Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

Greicy H. Goto, Hiroo Ogi, Himadri Biswas, Avik Ghosh, Seiji Tanaka, Katsunori Sugimoto

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006873

Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA

Xi Cheng, Harshal Waghulde, Blair Mell, Eric E. Morgan, Shondra M. Pruett-Miller, Bina Joe

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006961

Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries

Radha Raman Pandey, David Homolka, Kuan-Ming Chen, Ravi Sachidanandam, Marie-Odile Fauvarque, Ramesh S. Pillai

PLOS Genetics: published August 21, 2017 | https://doi.org/10.1371/journal.pgen.1006956

Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans

Rachele Sangaletti, Massimo D’Amico, Jeff Grant, David Della-Morte, Laura Bianchi

PLOS Genetics: published August 18, 2017 | https://doi.org/10.1371/journal.pgen.1006965

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

Ashley Snouffer, Desmond Brown, Hankyu Lee, Jonathon Walsh, Floria Lupu, Ryan Norman, Karl Lechtreck, Hyuk Wan Ko, Jonathan Eggenschwiler

PLOS Genetics: published August 17, 2017 | https://doi.org/10.1371/journal.pgen.1006912

Tissue-specific insulin signaling mediates female sexual attractiveness

Tatyana Y. Fedina, Devin Arbuthnott, Howard D. Rundle, Daniel E. L. Promislow, Scott D. Pletcher

PLOS Genetics: published August 17, 2017 | https://doi.org/10.1371/journal.pgen.1006935

Fruit weight is controlled by Cell Size Regulator encoding a novel protein that is expressed in maturing tomato fruits

Qi Mu, Zejun Huang, Manohar Chakrabarti, Eudald Illa-Berenguer, Xiaoxi Liu, Yanping Wang, Alexis Ramos, Esther van der Knaap

PLOS Genetics: published August 17, 2017 | https://doi.org/10.1371/journal.pgen.1006930

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Altea Rocchi, Soh Yamamoto, Tabitha Ting, Yuying Fan, Katherine Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006962

Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA

Divya Ramalingam Iyer, Nicholas Rhind

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006958

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways

Michael Crompton, Tom Purnell, Hayley E. Tyrer, Andrew Parker, Greg Ball, Rachel E. Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H. Dean, Michelle M. Simon, Ann-Marie Mallon, Sara Wells, Mahmood F. Bhutta, Martin J. Burton, Hilda Tateossian, Steve D. M. Brown

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006969

Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study

Paul J. Leo, Margaret M. Madeleine, Sophia Wang, Stephen M. Schwartz, Felicity Newell, Ulrika Pettersson-Kymmer, Kari Hemminki, Goran Hallmans, Sven Tiews, Winfried Steinberg, Janet S. Rader, Felipe Castro, Mahboobeh Safaeian, Eduardo L. Franco, François Coutlée, Claes Ohlsson, Adrian Cortes, Mhairi Marshall, Pamela Mukhopadhyay, Katie Cremin, Lisa G. Johnson, Suzanne Garland, Sepehr N. Tabrizi, Nicolas Wentzensen, Freddy Sitas, Julian Little, Maggie Cruickshank, Ian H. Frazer, Allan Hildesheim, Matthew A. Brown

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006866

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Loss of the chromatin modifier Kdm2aa causes Braf^V600E-independent spontaneous melanoma in zebrafish

Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006959

PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzae

Yang Li, Xue Zhang, Shuai Hu, Huiquan Liu, Jin-Rong Xu

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006954

A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

Claire J. Cairney, Lauren S. Godwin, Alan E. Bilsland, Sharon Burns, Katrina H. Stevenson, Lynn McGarry, John Revie, Jon D. Moore, Ceri M. Wiggins, Rebecca S. Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C. Bennett, Masashi Narita, Christopher J. Torrance, W. Nicol Keith

PLOS Genetics: published August 14, 2017 | https://doi.org/10.1371/journal.pgen.1006942

A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development

Tobias Bohnenpoll, Anna B. Wittern, Tamrat M. Mamo, Anna-Carina Weiss, Carsten Rudat, Marc-Jens Kleppa, Karin Schuster-Gossler, Irina Wojahn, Timo H.-W. Lüdtke, Mark-Oliver Trowe, Andreas Kispert

PLOS Genetics: published August 10, 2017 | https://doi.org/10.1371/journal.pgen.1006951

Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes

Emilie J. Richards, Christopher H. Martin

PLOS Genetics: published August 10, 2017 | https://doi.org/10.1371/journal.pgen.1006919

Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency

Virginia E. Glazier, Thomas Murante, Daniel Murante, Kristy Koselny, Yuan Liu, Dongyeop Kim, Hyun Koo, Damian J. Krysan

PLOS Genetics: published August 9, 2017 | https://doi.org/10.1371/journal.pgen.1006948

Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation

Jérémy Manry, Yohann Nédélec, Vinicius M. Fava, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Vu Hong Thai, Guillaume Laval, Luis B. Barreiro, Erwin Schurr

PLOS Genetics: published August 9, 2017 | https://doi.org/10.1371/journal.pgen.1006952

Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries

Eric W. Lin, Tatiana A. Karakasheva, Dong-Jin Lee, Ju-Seog Lee, Qi Long, Adam J. Bass, Kwok K. Wong, Anil K. Rustgi

PLOS Genetics: published August 7, 2017 | https://doi.org/10.1371/journal.pgen.1006938

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Rare coding variants pinpoint genes that control human hematological traits

Abdou Mousas, Georgios Ntritsos, Ming-Huei Chen, Ci Song, Jennifer E. Huffman, Ioanna Tzoulaki, Paul Elliott, Bruce M. Psaty, Blood-Cell Consortium, Paul L. Auer, Andrew D. Johnson, Evangelos Evangelou, Guillaume Lettre, Alexander P. Reiner

PLOS Genetics: published August 7, 2017 | https://doi.org/10.1371/journal.pgen.1006925

SCF^AtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana

Chunhong Cheng, Zhijuan Wang, Ziyin Ren, Liya Zhi, Bin Yao, Chao Su, Liu Liu, Xia Li

PLOS Genetics: published August 7, 2017 | https://doi.org/10.1371/journal.pgen.1006947

MicroRNA-275 targets sarco/endoplasmic reticulum Ca²⁺ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut

Bo Zhao, Keira J. Lucas, Tusar T. Saha, Jisu Ha, Lin Ling, Vladimir A. Kokoza, Sourav Roy, Alexander S. Raikhel

PLOS Genetics: published August 7, 2017 | https://doi.org/10.1371/journal.pgen.1006943

Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO₂ sensing and hyphal development in Candida albicans

Li Tao, Yulong Zhang, Shuru Fan, Clarissa J. Nobile, Guobo Guan, Guanghua Huang

PLOS Genetics: published August 7, 2017 | https://doi.org/10.1371/journal.pgen.1006949

Comprehensive analysis of nucleocytoplasmic dynamics of mRNA in Drosophila cells

Tao Chen, Bas van Steensel

PLOS Genetics: published August 3, 2017 | https://doi.org/10.1371/journal.pgen.1006929

Deconstructing isolation-by-distance: The genomic consequences of limited dispersal

Stepfanie M. Aguillon, John W. Fitzpatrick, Reed Bowman, Stephan J. Schoech, Andrew G. Clark, Graham Coop, Nancy Chen

PLOS Genetics: published August 3, 2017 | https://doi.org/10.1371/journal.pgen.1006911

Variation of the meiotic recombination landscape and properties over a broad evolutionary distance in yeasts

Christian Brion, Sylvain Legrand, Jackson Peter, Claudia Caradec, David Pflieger, Jing Hou, Anne Friedrich, Bertrand Llorente, Joseph Schacherer

PLOS Genetics: published August 1, 2017 | https://doi.org/10.1371/journal.pgen.1006917