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Pigs are an excellent model to study harmful mutations causing embryonic lethality in homozygous affected individuals. In their study, Derks et al. identified five such recessive loci that impair the function of essential genes causing embryonic lethality in pigs. The lethal recessives affect up to 3% of the population litters, responsible for the death of 1 in 200 embryos. The study is intended to be used to lower the frequency of these harmful mutations to improve fertility in popular commercial pig breeds. See Derks et al.

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Image Credit: Anatolii Tsekhmister

Editorial

The Plight of Muntaser Ibrahim

Giorgio Sirugo, Scott M. Williams, Sarah A. Tishkoff, Heather J. Cordell, Jonathan Marchini, Gregory S. Barsh, Gregory P. Copenhaver

PLOS Genetics: published March 25, 2019 | https://doi.org/10.1371/journal.pgen.1008100

Viewpoints

Collateral damage and CRISPR genome editing

Mark Thomas, Gaetan Burgio, David J. Adams, Vivek Iyer

PLOS Genetics: published March 14, 2019 | https://doi.org/10.1371/journal.pgen.1007994

Review

Errors in translational decoding: tRNA wobbling or misincorporation?

Xumin Ou, Jingyu Cao, Anchun Cheng, Maikel P. Peppelenbosch, Qiuwei Pan

PLOS Genetics: published March 28, 2019 | https://doi.org/10.1371/journal.pgen.1008017

Research Articles

Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model

Lihui Wang, Megan A. Sloan, Petros Ligoxygakis

PLOS Genetics: published March 1, 2019 | https://doi.org/10.1371/journal.pgen.1007931

Live cell monitoring of double strand breaks in S. cerevisiae

David P. Waterman, Felix Zhou, Kevin Li, Cheng-Sheng Lee, Michael Tsabar, Vinay V. Eapen, Allison Mazzella, James E. Haber

PLOS Genetics: published March 1, 2019 | https://doi.org/10.1371/journal.pgen.1008001

Evolution of an insect immune barrier through horizontal gene transfer mediated by a parasitic wasp

Ilaria Di Lelio, Anna Illiano, Federica Astarita, Luca Gianfranceschi, David Horner, Paola Varricchio, Angela Amoresano, Pietro Pucci, Francesco Pennacchio, Silvia Caccia

PLOS Genetics: published March 5, 2019 | https://doi.org/10.1371/journal.pgen.1007998

The complex geography of domestication of the African rice Oryza glaberrima

Jae Young Choi, Maricris Zaidem, Rafal Gutaker, Katherine Dorph, Rakesh Kumar Singh, Michael D. Purugganan

PLOS Genetics: published March 7, 2019 | https://doi.org/10.1371/journal.pgen.1007414

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper

PLOS Genetics: published March 7, 2019 | https://doi.org/10.1371/journal.pgen.1007633

Control of proliferation in the haploid meristem by CLE peptide signaling in Marchantia polymorpha

Yuki Hirakawa, Naoyuki Uchida, Yasuka L. Yamaguchi, Ryo Tabata, Sakiko Ishida, Kimitsune Ishizaki, Ryuichi Nishihama, Takayuki Kohchi, Shinichiro Sawa, John L. Bowman

PLOS Genetics: published March 7, 2019 | https://doi.org/10.1371/journal.pgen.1007997

Molecular and cellular modulators for multisensory integration in C. elegans

Gareth Harris, Taihong Wu, Gaia Linfield, Myung-Kyu Choi, He Liu, Yun Zhang

PLOS Genetics: published March 8, 2019 | https://doi.org/10.1371/journal.pgen.1007706

Genetic effects on the commensal microbiota in inflammatory bowel disease patients

Hugues Aschard, Vincent Laville, Eric Tchetgen Tchetgen, Dan Knights, Floris Imhann, Philippe Seksik, Noah Zaitlen, Mark S. Silverberg, Jacques Cosnes, Rinse K. Weersma, Ramnik Xavier, Laurent Beaugerie, David Skurnik, Harry Sokol

PLOS Genetics: published March 8, 2019 | https://doi.org/10.1371/journal.pgen.1008018

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

Mateus H. Gouveia, Andrew W. Bergen, Victor Borda, Kelly Nunes, Thiago P. Leal, Martin D. Ogwang, Edward D. Yeboah, James E. Mensah, Tobias Kinyera, Isaac Otim, Hadijah Nabalende, Ismail D. Legason, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Patrick Kerchan, Kishor Bhatia, Steven J. Reynolds, Richard B. Birtwum, Andrew A. Adjei, Yao Tettey, Evelyn Tay, Robert Hoover, Ruth M. Pfeiffer, Robert J. Biggar, James J. Goedert, Ludmila Prokunina-Olsson, Michael Dean, Meredith Yeager, M. Fernanda Lima-Costa, Ann W. Hsing, Sarah A. Tishkoff, Stephen J. Chanock, Eduardo Tarazona-Santos, Sam M. Mbulaiteye

PLOS Genetics: published March 8, 2019 | https://doi.org/10.1371/journal.pgen.1008027

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy

Mark T. Handley, Kaalak Reddy, Jimi Wills, Elisabeth Rosser, Archith Kamath, Mihail Halachev, Gavin Falkous, Denise Williams, Phillip Cox, Alison Meynert, Eleanor S. Raymond, Harris Morrison, Stephen Brown, Emma Allan, Irene Aligianis, Andrew P. Jackson, Bernard H. Ramsahoye, Alex von Kriegsheim, Robert W. Taylor, Andrew J. Finch, David R. FitzPatrick

PLOS Genetics: published March 11, 2019 | https://doi.org/10.1371/journal.pgen.1007605

Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast

Kevin S. Myers, Nicholas M. Riley, Matthew E. MacGilvray, Trey K. Sato, Mick McGee, Justin Heilberger, Joshua J. Coon, Audrey P. Gasch

PLOS Genetics: published March 11, 2019 | https://doi.org/10.1371/journal.pgen.1008037

Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice

Martin Peterka, Benoît Kornmann

PLOS Genetics: published March 11, 2019 | https://doi.org/10.1371/journal.pgen.1008050

Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans

Alexey V. Revtovich, Ryan Lee, Natalia V. Kirienko

PLOS Genetics: published March 13, 2019 | https://doi.org/10.1371/journal.pgen.1008011

The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte

Justinn Barr, Sofia Charania, Rudolf Gilmutdinov, Konstantin Yakovlev, Yulii Shidlovskii, Paul Schedl

PLOS Genetics: published March 13, 2019 | https://doi.org/10.1371/journal.pgen.1008012

Connective auxin transport contributes to strigolactone-mediated shoot branching control independent of the transcription factor BRC1

Martin van Rongen, Tom Bennett, Fabrizio Ticchiarelli, Ottoline Leyser

PLOS Genetics: published March 13, 2019 | https://doi.org/10.1371/journal.pgen.1008023

LINE-2 transposable elements are a source of functional human microRNAs and target sites

Rebecca Petri, Per Ludvik Brattås, Yogita Sharma, Marie E. Jönsson, Karolina Pircs, Johan Bengzon, Johan Jakobsson

PLOS Genetics: published March 13, 2019 | https://doi.org/10.1371/journal.pgen.1008036

Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1)

Yun Liu, Yoshie Sugiura, Fujun Chen, Kuo-Fen Lee, Qiaohong Ye, Weichun Lin

PLOS Genetics: published March 14, 2019 | https://doi.org/10.1371/journal.pgen.1007857

Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal

Thomas W. Gould, Bertha Dominguez, Fred de Winter, Gene W. Yeo, Patrick Liu, Balaji Sundararaman, Thomas Stark, Anthony Vu, Jay L. Degen, Weichun Lin, Kuo-Fen Lee

PLOS Genetics: published March 14, 2019 | https://doi.org/10.1371/journal.pgen.1007948

Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic

Ryan Sun, Shirley Hui, Gary D. Bader, Xihong Lin, Peter Kraft

PLOS Genetics: published March 15, 2019 | https://doi.org/10.1371/journal.pgen.1007530

Regulation of anthocyanin accumulation via MYB75/HAT1/TPL-mediated transcriptional repression

Ting Zheng, Wenrong Tan, Huan Yang, Li’e Zhang, Taotao Li, Baohui Liu, Dawei Zhang, Honghui Lin

PLOS Genetics: published March 15, 2019 | https://doi.org/10.1371/journal.pgen.1007993

The molecular and cellular basis of olfactory response to tsetse fly attractants

J. Sebastian Chahda, Neeraj Soni, Jennifer S. Sun, Shimaa A. M. Ebrahim, Brian L. Weiss, John R. Carlson

PLOS Genetics: published March 15, 2019 | https://doi.org/10.1371/journal.pgen.1008005

The dynamin-like protein Fzl promotes thylakoid fusion and resistance to light stress in Chlamydomonas reinhardtii

Justin Findinier, Cédric Delevoye, Mickael M. Cohen

PLOS Genetics: published March 15, 2019 | https://doi.org/10.1371/journal.pgen.1008047

Loss of function mutations in essential genes cause embryonic lethality in pigs

Martijn F. L. Derks, Arne B. Gjuvsland, Mirte Bosse, Marcos S. Lopes, Maren van Son, Barbara Harlizius, Beatrice F. Tan, Hanne Hamland, Eli Grindflek, Martien A. M. Groenen, Hendrik-Jan Megens

PLOS Genetics: published March 15, 2019 | https://doi.org/10.1371/journal.pgen.1008055

Cellular response to small molecules that selectively stall protein synthesis by the ribosome

Nadège Liaud, Max A. Horlbeck, Luke A. Gilbert, Ketrin Gjoni, Jonathan S. Weissman, Jamie H. D. Cate

PLOS Genetics: published March 15, 2019 | https://doi.org/10.1371/journal.pgen.1008057

Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans

Nadia Elramli, Betim Karahoda, Özlem Sarikaya-Bayram, Dean Frawley, Mevlüt Ulas, C. Elizabeth Oakley, Berl R. Oakley, Stephan Seiler, Özgür Bayram

PLOS Genetics: published March 18, 2019 | https://doi.org/10.1371/journal.pgen.1008053

An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease

Suvi Mäkeläinen, Marta Gòdia, Minas Hellsand, Agnese Viluma, Daniela Hahn, Karim Makdoumi, Caroline J. Zeiss, Cathryn Mellersh, Sally L. Ricketts, Kristina Narfström, Finn Hallböök, Björn Ekesten, Göran Andersson, Tomas F. Bergström

PLOS Genetics: published March 19, 2019 | https://doi.org/10.1371/journal.pgen.1007873

Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing

Kathryn J. Grive, Yang Hu, Eileen Shu, Andrew Grimson, Olivier Elemento, Jennifer K. Grenier, Paula E. Cohen

PLOS Genetics: published March 20, 2019 | https://doi.org/10.1371/journal.pgen.1007810

A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh

Brandon L. Pierce, Lin Tong, Samantha Dean, Maria Argos, Farzana Jasmine, Muhammad Rakibuz-Zaman, Golam Sarwar, Md. Tariqul Islam, Hasan Shahriar, Tariqul Islam, Mahfuzar Rahman, Md. Yunus, Vincent J. Lynch, Devin Oglesbee, Joseph H. Graziano, Muhammad G. Kibriya, Mary V. Gamble, Habibul Ahsan

PLOS Genetics: published March 20, 2019 | https://doi.org/10.1371/journal.pgen.1007984

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

Lina Ding, Lauren B. Shunkwiler, Nicholas W. Harper, Yang Zhao, Kunihiko Hinohara, Sung Jin Huh, Muhammad B. Ekram, Jan Guz, Michael J. Kern, Alexander Awgulewitsch, James D. Shull, Bart M. G. Smits, Kornelia Polyak

PLOS Genetics: published March 20, 2019 | https://doi.org/10.1371/journal.pgen.1008002

Polygenic adaptation: From sweeps to subtle frequency shifts

Ilse Höllinger, Pleuni S. Pennings, Joachim Hermisson

PLOS Genetics: published March 20, 2019 | https://doi.org/10.1371/journal.pgen.1008035

Hypomorphic mutation of the mouse Huntington’s disease gene orthologue

Vidya Murthy, Toma Tebaldi, Toshimi Yoshida, Serkan Erdin, Teresa Calzonetti, Ravi Vijayvargia, Takshashila Tripathi, Emanuela Kerschbamer, Ihn Sik Seong, Alessandro Quattrone, Michael E. Talkowski, James F. Gusella, Katia Georgopoulos, Marcy E. MacDonald, Marta Biagioli

PLOS Genetics: published March 21, 2019 | https://doi.org/10.1371/journal.pgen.1007765

A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers

Deborah Biasoli, Lara Compston-Garnett, Sally L. Ricketts, Zeynep Birand, Celine Courtay-Cahen, Elena Fineberg, Maja Arendt, Kim Boerkamp, Malin Melin, Michele Koltookian, Sue Murphy, Gerard Rutteman, Kerstin Lindblad-Toh, Mike Starkey

PLOS Genetics: published March 22, 2019 | https://doi.org/10.1371/journal.pgen.1007967

Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans

Loubna Youssar, Valentin Wernet, Nicole Hensel, Xi Yu, Heinz-Georg Hildebrand, Birgit Schreckenberger, Marius Kriegler, Birgit Hetzer, Phillip Frankino, Andrew Dillin, Reinhard Fischer

PLOS Genetics: published March 27, 2019 | https://doi.org/10.1371/journal.pgen.1008029

Genomic inversions and GOLGA core duplicons underlie disease instability at the 15q25 locus

Flavia A. M. Maggiolini, Stuart Cantsilieris, Pietro D’Addabbo, Michele Manganelli, Bradley P. Coe, Beth L. Dumont, Ashley D. Sanders, Andy Wing Chun Pang, Mitchell R. Vollger, Orazio Palumbo, Pietro Palumbo, Maria Accadia, Massimo Carella, Evan E. Eichler, Francesca Antonacci

PLOS Genetics: published March 27, 2019 | https://doi.org/10.1371/journal.pgen.1008075

The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing

Katherine Kretovich Billmyre, Anna-Lisa Doebley, Maya Spichal, Bree Heestand, Tony Belicard, Aya Sato-Carlton, Stephane Flibotte, Matt Simon, Megan Gnazzo, Ahna Skop, Donald Moerman, Peter Mark Carlton, Peter Sarkies, Shawn Ahmed

PLOS Genetics: published March 28, 2019 | https://doi.org/10.1371/journal.pgen.1008004

The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans

Adnane Sellam, Julien Chaillot, Jaideep Mallick, Faiza Tebbji, Julien Richard Albert, Michael A. Cook, Mike Tyers

PLOS Genetics: published March 28, 2019 | https://doi.org/10.1371/journal.pgen.1008052

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity

Aleksandra I. Adamovich, Tapahsama Banerjee, Margaret Wingo, Kathryn Duncan, Jie Ning, Fernanda Martins Rodrigues, Kuan-lin Huang, Cindy Lee, Feng Chen, Li Ding, Jeffrey D. Parvin

PLOS Genetics: published March 29, 2019 | https://doi.org/10.1371/journal.pgen.1008049

Antero-posterior ectoderm patterning by canonical Wnt signaling during ascidian development

Stacy Feinberg, Agnès Roure, Julie Piron, Sébastien Darras

PLOS Genetics: published March 29, 2019 | https://doi.org/10.1371/journal.pgen.1008054

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R. A. Regenbrecht

PLOS Genetics: published March 29, 2019 | https://doi.org/10.1371/journal.pgen.1008076

Corrections

Correction: CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse

Zhenzhen Zi, Zhuzhen Zhang, Qingrun Li, Weiwei An, Liyong Zeng, Dayuan Gao, Ying Yang, Xueliang Zhu, Rong Zeng, Winnie Waichi Shum, Jiarui Wu

PLOS Genetics: published March 4, 2019 | https://doi.org/10.1371/journal.pgen.1008021

Correction: Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development

Yun Huang, Cui-Zhu Feng, Qing Ye, Wei-Hua Wu, Yi-Fang Chen

PLOS Genetics: published March 6, 2019 | https://doi.org/10.1371/journal.pgen.1008032

Correction: EAT1 transcription factor, a non-cell-autonomous regulator of pollen production, activates meiotic small RNA biogenesis in rice anther tapetum

Seijiro Ono, Hua Liu, Katsutoshi Tsuda, Eigo Fukai, Keisuke Tanaka, Takuji Sasaki, Ken-Ichi Nonomura

PLOS Genetics: published March 6, 2019 | https://doi.org/10.1371/journal.pgen.1008033

March 2019

Cover

Embryonic lethals impairing fertility in pigs.

Editorial

Viewpoints

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Review

Research Articles

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