The joy of balancers

Danny E. Miller, Kevin R. Cook, R. Scott Hawley

PLOS Genetics: published November 7, 2019 | https://doi.org/10.1371/journal.pgen.1008421

Mouse protein coding diversity: What’s left to discover?

Jingtao Lilue, Anu Shivalikanjli, David J. Adams, Thomas M. Keane

PLOS Genetics: published November 14, 2019 | https://doi.org/10.1371/journal.pgen.1008446

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes

Anaïs Darracq, Helen Pak, Vincent Bourgoin, Farah Zmiri, Graham Dellaire, El Bachir Affar, Eric Milot

PLOS Genetics: published November 1, 2019 | https://doi.org/10.1371/journal.pgen.1008463

UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts

Alex Diaz-Papkovich, Luke Anderson-Trocmé, Chief Ben-Eghan, Simon Gravel

PLOS Genetics: published November 1, 2019 | https://doi.org/10.1371/journal.pgen.1008432

Genomic dissection of an extended phenotype: Oak galling by a cynipid gall wasp

Jack Hearn, Mark Blaxter, Karsten Schönrogge, José-Luis Nieves-Aldrey, Juli Pujade-Villar, Elisabeth Huguet, Jean-Michel Drezen, Joseph D. Shorthouse, Graham N. Stone

PLOS Genetics: published November 4, 2019 | https://doi.org/10.1371/journal.pgen.1008398

Systems genomics approaches provide new insights into Arabidopsis thaliana root growth regulation under combinatorial mineral nutrient limitation

Nadia Bouain, Arthur Korte, Santosh B. Satbhai, Hye-In Nam, Seung Y. Rhee, Wolfgang Busch, Hatem Rouached

PLOS Genetics: published November 6, 2019 | https://doi.org/10.1371/journal.pgen.1008392

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Chromatin dynamics enable transcriptional rhythms in the cnidarian Nematostella vectensis

Eviatar N. Weizman, Miriam Tannenbaum, Ann M. Tarrant, Ofir Hakim, Oren Levy

PLOS Genetics: published November 6, 2019 | https://doi.org/10.1371/journal.pgen.1008397

A circadian output center controlling feeding:fasting rhythms in Drosophila

Austin P. Dreyer, Madison M. Martin, Carson V. Fulgham, Daniel A. Jabr, Lei Bai, Jennifer Beshel, Daniel J. Cavanaugh

PLOS Genetics: published November 6, 2019 | https://doi.org/10.1371/journal.pgen.1008478

Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice

Rena M. Schweizer, Jonathan P. Velotta, Catherine M. Ivy, Matthew R. Jones, Sarah M. Muir, Gideon S. Bradburd, Jay F. Storz, Graham R. Scott, Zachary A. Cheviron

PLOS Genetics: published November 7, 2019 | https://doi.org/10.1371/journal.pgen.1008420

The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries)

Alexandra M. Sparks, Kathryn Watt, Rona Sinclair, Jill G. Pilkington, Josephine M. Pemberton, Tom N. McNeilly, Daniel H. Nussey, Susan E. Johnston

PLOS Genetics: published November 7, 2019 | https://doi.org/10.1371/journal.pgen.1008461

Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth

Ritu Sarpal, Victoria Yan, Lidia Kazakova, Luka Sheppard, Jessica C. Yu, Rodrigo Fernandez-Gonzalez, Ulrich Tepass

PLOS Genetics: published November 7, 2019 | https://doi.org/10.1371/journal.pgen.1008454

Linking high GC content to the repair of double strand breaks in prokaryotic genomes

JL Weissman, William F. Fagan, Philip L. F. Johnson

PLOS Genetics: published November 8, 2019 | https://doi.org/10.1371/journal.pgen.1008493

SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila

Yongbo Xue, Joanna C. Chiu, Yong Zhang

PLOS Genetics: published November 11, 2019 | https://doi.org/10.1371/journal.pgen.1008475

Microbial phenotypic heterogeneity in response to a metabolic toxin: Continuous, dynamically shifting distribution of formaldehyde tolerance in Methylobacterium extorquens populations

Jessica A. Lee, Siavash Riazi, Shahla Nemati, Jannell V. Bazurto, Andreas E. Vasdekis, Benjamin J. Ridenhour, Christopher H. Remien, Christopher J. Marx

PLOS Genetics: published November 11, 2019 | https://doi.org/10.1371/journal.pgen.1008458

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1. Correction: Microbial phenotypic heterogeneity in response to a metabolic toxin: Continuous, dynamically shifting distribution of formaldehyde tolerance in Methylobacterium extorquens populations

Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania

Megan A. Sloan, Karen Brooks, Thomas D. Otto, Mandy J. Sanders, James A. Cotton, Petros Ligoxygakis

PLOS Genetics: published November 11, 2019 | https://doi.org/10.1371/journal.pgen.1008452

Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging

Megumi Shigematsu, Keisuke Morichika, Takuya Kawamura, Shozo Honda, Yohei Kirino

PLOS Genetics: published November 13, 2019 | https://doi.org/10.1371/journal.pgen.1008469

Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila

Ying Liu, Hong Bao, Weidong Wang, Hui-Ying Lim

PLOS Genetics: published November 14, 2019 | https://doi.org/10.1371/journal.pgen.1008487

Inference of recombination maps from a single pair of genomes and its application to ancient samples

Gustavo V. Barroso, Nataša Puzović, Julien Y. Dutheil

PLOS Genetics: published November 14, 2019 | https://doi.org/10.1371/journal.pgen.1008449

SON protects nascent transcripts from unproductive degradation by counteracting DIP1

Mandy Li-Ian Tay, Jun Wei Pek

PLOS Genetics: published November 15, 2019 | https://doi.org/10.1371/journal.pgen.1008498

Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants

John Snedeker, William J. Gibbons Jr., David F. Paulding, Zakia Abdelhamed, Daniel R. Prows, Rolf W. Stottmann

PLOS Genetics: published November 15, 2019 | https://doi.org/10.1371/journal.pgen.1008467

Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies

Andrew Schlafly, Ruth M. Pfeiffer, Eduardo Nagore, Susana Puig, Donato Calista, Paola Ghiorzo, Chiara Menin, Maria Concetta Fargnoli, Ketty Peris, Lei Song, Tongwu Zhang, Jianxin Shi, Maria Teresa Landi, Joshua Neil Sampson

PLOS Genetics: published November 15, 2019 | https://doi.org/10.1371/journal.pgen.1008490

AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation

Jianhui Li, Michal Breker, Morven Graham, Maya Schuldiner, Mark Hochstrasser

PLOS Genetics: published November 18, 2019 | https://doi.org/10.1371/journal.pgen.1008387

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DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories

Sheila Lutz, Christian Brion, Margaret Kliebhan, Frank W. Albert

PLOS Genetics: published November 18, 2019 | https://doi.org/10.1371/journal.pgen.1008375

A meta-analysis of genome-wide association studies of epigenetic age acceleration

Jude Gibson, Tom C. Russ, Toni-Kim Clarke, David M. Howard, Robert F. Hillary, Kathryn L. Evans, Rosie M. Walker, Mairead L. Bermingham, Stewart W. Morris, Archie Campbell, Caroline Hayward, Alison D. Murray, David J. Porteous, Steve Horvath, Ake T. Lu, Andrew M. McIntosh, Heather C. Whalley, Riccardo E. Marioni

PLOS Genetics: published November 18, 2019 | https://doi.org/10.1371/journal.pgen.1008104

CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline

Benjamin Alleva, Sean Clausen, Emily Koury, Adam Hefel, Sarit Smolikove

PLOS Genetics: published November 18, 2019 | https://doi.org/10.1371/journal.pgen.1008486

Ancestral male recombination in Drosophila albomicans produced geographically restricted neo-Y chromosome haplotypes varying in age and onset of decay

Kevin H-C. Wei, Doris Bachtrog

PLOS Genetics: published November 18, 2019 | https://doi.org/10.1371/journal.pgen.1008502

Photodamage repair pathways contribute to the accurate maintenance of the DNA methylome landscape upon UV exposure

Stéfanie Graindorge, Valérie Cognat, Philippe Johann to Berens, Jérôme Mutterer, Jean Molinier

PLOS Genetics: published November 18, 2019 | https://doi.org/10.1371/journal.pgen.1008476

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

Hong Li, Michael Marceau, Tiandi Yang, Tingting Liao, Xiaoqiong Tang, Renwei Hu, Yan Xie, Hong Tang, Alfred Tay, Ying Shi, Yalin Shen, Tiankuo Yang, Xuenan Pi, Binit Lamichhane, Yong Luo, Aleksandra W. Debowski, Hans-Olof Nilsson, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Barry J. Marshall, Mohammed Benghezal

PLOS Genetics: published November 20, 2019 | https://doi.org/10.1371/journal.pgen.1008497

Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation

Raymond T. Suhandynata, Yun Quan, Yusheng Yang, Wei-Tsung Yuan, Claudio P. Albuquerque, Huilin Zhou

PLOS Genetics: published November 20, 2019 | https://doi.org/10.1371/journal.pgen.1008477

Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication

Xiangzhou Meng, Lei Wei, Xiao P. Peng, Xiaolan Zhao

PLOS Genetics: published November 25, 2019 | https://doi.org/10.1371/journal.pgen.1008426

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The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Alicja Winczura, Rowin Appanah, Michael H. Tatham, Ronald T. Hay, Giacomo De Piccoli

PLOS Genetics: published November 25, 2019 | https://doi.org/10.1371/journal.pgen.1008427

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Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

Mihail Halachev, Alison Meynert, Martin S. Taylor, Veronique Vitart, Shona M. Kerr, Lucija Klaric, S. G. P. Consortium, Timothy J. Aitman, Chris S. Haley, James G. Prendergast, Carys Pugh, David A. Hume, Sarah E. Harris, David C. Liewald, Ian J. Deary, Colin A. Semple, James F. Wilson

PLOS Genetics: published November 25, 2019 | https://doi.org/10.1371/journal.pgen.1008480

The impact of genetic adaptation on chimpanzee subspecies differentiation

Joshua M. Schmidt, Marc de Manuel, Tomas Marques-Bonet, Sergi Castellano, Aida M. Andrés

PLOS Genetics: published November 25, 2019 | https://doi.org/10.1371/journal.pgen.1008485

STK-12 acts as a transcriptional brake to control the expression of cellulase-encoding genes in Neurospora crassa

Liangcai Lin, Shanshan Wang, Xiaolin Li, Qun He, J. Philipp Benz, Chaoguang Tian

PLOS Genetics: published November 25, 2019 | https://doi.org/10.1371/journal.pgen.1008510

Availability of splicing factors in the nucleoplasm can regulate the release of mRNA from the gene after transcription

Hodaya Hochberg-Laufer, Noa Neufeld, Yehuda Brody, Shani Nadav-Eliyahu, Rakefet Ben-Yishay, Yaron Shav-Tal

PLOS Genetics: published November 25, 2019 | https://doi.org/10.1371/journal.pgen.1008459

Correction: Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans

Yang Zhou, Yan Qin, Yingying Qin, Binyang Xu, Ting Guo, Hanni Ke, Min Chen, Lianjun Zhang, Feng Han, Yaqiong Li, Min Chen, Axel Behrens, Yaqing Wang, Zhiheng Xu, Zi-Jiang Chen, Fei Gao

PLOS Genetics: published November 15, 2019 | https://doi.org/10.1371/journal.pgen.1008504

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The great hairball gambit

Jonathan Flint, Trey Ideker

PLOS Genetics: published November 26, 2019 | https://doi.org/10.1371/journal.pgen.1008519

Eukaryote hybrid genomes

Anna Runemark, Mario Vallejo-Marin, Joana I. Meier

PLOS Genetics: published November 27, 2019 | https://doi.org/10.1371/journal.pgen.1008404