Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain

Daniela Torres-Campana, Béatrice Horard, Sandrine Denaud, Gérard Benoit, Benjamin Loppin, Guillermo A. Orsi

PLOS Genetics: published January 4, 2022 | https://doi.org/10.1371/journal.pgen.1009615

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

Jeffrey M. Hollomon, Zhongle Liu, Scott F. Rusin, Nicole P. Jenkins, Allia K. Smith, Katja Koeppen, Arminja N. Kettenbach, Lawrence C. Myers, Deborah A. Hogan

PLOS Genetics: published January 4, 2022 | https://doi.org/10.1371/journal.pgen.1009622

The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo

Jayson J. Smith, Yutong Xiao, Nithin Parsan, Taylor N. Medwig-Kinney, Michael A. Q. Martinez, Frances E. Q. Moore, Nicholas J. Palmisano, Abraham Q. Kohrman, Mana Chandhok Delos Reyes, Rebecca C. Adikes, Simeiyun Liu, Sydney A. Bracht, Wan Zhang, Kailong Wen, Paschalis Kratsios, David Q. Matus

PLOS Genetics: published January 4, 2022 | https://doi.org/10.1371/journal.pgen.1009981

Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity

Matthew D. Vandermeulen, Paul J. Cullen

PLOS Genetics: published January 4, 2022 | https://doi.org/10.1371/journal.pgen.1009988

The impact of SBF2 on taxane-induced peripheral neuropathy

Geneva M. Cunningham, Fei Shen, Xi Wu, Erica L. Cantor, Laura Gardner, Santosh Philips, Guanglong Jiang, Casey L. Bales, Zhiyong Tan, Yunlong Liu, Jun Wan, Jill C. Fehrenbacher, Bryan P. Schneider

PLOS Genetics: published January 5, 2022 | https://doi.org/10.1371/journal.pgen.1009968

Identification of the potential active site of the septal peptidoglycan polymerase FtsW

Ying Li, Adrien Boes, Yuanyuan Cui, Shan Zhao, Qingzhen Liao, Han Gong, Eefjan Breukink, Joe Lutkenhaus, Mohammed Terrak, Shishen Du

PLOS Genetics: published January 5, 2022 | https://doi.org/10.1371/journal.pgen.1009993

Preformation and epigenesis converge to specify primordial germ cell fate in the early Drosophila embryo

Megan M. Colonnetta, Yogesh Goyal, Heath E. Johnson, Sapna Syal, Paul Schedl, Girish Deshpande

PLOS Genetics: published January 5, 2022 | https://doi.org/10.1371/journal.pgen.1010002

Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila

Michelle Ledru, Caitlin A. Clark, Jeremy Brown, Shilpi Verghese, Sarah Ferrara, Andrew Goodspeed, Tin Tin Su

PLOS Genetics: published January 6, 2022 | https://doi.org/10.1371/journal.pgen.1009989

Population-level genome-wide STR discovery and validation for population structure and genetic diversity assessment of Plasmodium species

Jiru Han, Jacob E. Munro, Anthony Kocoski, Alyssa E. Barry, Melanie Bahlo

PLOS Genetics: published January 10, 2022 | https://doi.org/10.1371/journal.pgen.1009604

Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila

Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros Ligoxygakis

PLOS Genetics: published January 10, 2022 | https://doi.org/10.1371/journal.pgen.1009992

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Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus

Ana Cristina Colabardini, Fang Wang, Zhengqiang Miao, Lakhansing Pardeshi, Clara Valero, Patrícia Alves de Castro, Daniel Yuri Akiyama, Kaeling Tan, Luisa Czamanski Nora, Rafael Silva-Rocha, Marina Marcet-Houben, Toni Gabaldón, Taicia Fill, Koon Ho Wong, Gustavo H. Goldman

PLOS Genetics: published January 10, 2022 | https://doi.org/10.1371/journal.pgen.1010001

Analysis of HubP-dependent cell pole protein targeting in Vibrio cholerae uncovers novel motility regulators

Ipek Altinoglu, Guillaume Abriat, Alexis Carreaux, Lucía Torres-Sánchez, Mickaël Poidevin, Petya Violinova Krasteva, Yoshiharu Yamaichi

PLOS Genetics: published January 12, 2022 | https://doi.org/10.1371/journal.pgen.1009991

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WAPO-A1 is the causal gene of the 7AL QTL for spikelet number per spike in wheat

Saarah Kuzay, Huiqiong Lin, Chengxia Li, Shisheng Chen, Daniel P. Woods, Junli Zhang, Tianyu Lan, Maria von Korff, Jorge Dubcovsky

PLOS Genetics: published January 13, 2022 | https://doi.org/10.1371/journal.pgen.1009747

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Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1

Hajime Okada, Yumiko Saga

PLOS Genetics: published January 13, 2022 | https://doi.org/10.1371/journal.pgen.1010000

Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior

Karo Tanaka, Vanessa Besson, Manon Rivagorda, Franck Oury, Giovanna Marazzi, David A. Sassoon

PLOS Genetics: published January 13, 2022 | https://doi.org/10.1371/journal.pgen.1010003

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

Cécile Ribot, Cédric Soler, Aymeric Chartier, Sandy Al Hayek, Rima Naït-Saïdi, Nicolas Barbezier, Olivier Coux, Martine Simonelig

PLOS Genetics: published January 13, 2022 | https://doi.org/10.1371/journal.pgen.1010015

Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy

Jianghong Cheng, Jia Liang, Yingzhe Li, Xia Gao, Mengjun Ji, Mengying Liu, Yingpu Tian, Gensheng Feng, Wenbo Deng, Haibin Wang, Shuangbo Kong, Zhongxian Lu

PLOS Genetics: published January 13, 2022 | https://doi.org/10.1371/journal.pgen.1010018

Comprehensive patient-level classification and quantification of driver events in TCGA PanCanAtlas cohorts

Alexey D. Vyatkin, Danila V. Otnyukov, Sergey V. Leonov, Aleksey V. Belikov

PLOS Genetics: published January 14, 2022 | https://doi.org/10.1371/journal.pgen.1009996

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

Patrícia Alves de Castro, Ana Cristina Colabardini, Maísa Moraes, Maria Augusta Crivelente Horta, Sonja L. Knowles, Huzefa A. Raja, Nicholas H. Oberlies, Yasuji Koyama, Masahiro Ogawa, Katsuya Gomi, Jacob L. Steenwyk, Antonis Rokas, Relber A. Gonçales, Cláudio Duarte-Oliveira, Agostinho Carvalho, Laure N. A. Ries, Gustavo H. Goldman

PLOS Genetics: published January 18, 2022 | https://doi.org/10.1371/journal.pgen.1009965

Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve

Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu

PLOS Genetics: published January 18, 2022 | https://doi.org/10.1371/journal.pgen.1010010

Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis

Jonathan Delhermite, Lionel Tafforeau, Sunny Sharma, Virginie Marchand, Ludivine Wacheul, Ruben Lattuca, Simon Desiderio, Yuri Motorin, Eric Bellefroid, Denis L. J. Lafontaine

PLOS Genetics: published January 18, 2022 | https://doi.org/10.1371/journal.pgen.1010012

Nicotinic acetylcholine receptor modulator insecticides act on diverse receptor subtypes with distinct subunit compositions

Wanjun Lu, Zhihan Liu, Xinyu Fan, Xinzhong Zhang, Xiaomu Qiao, Jia Huang

PLOS Genetics: published January 19, 2022 | https://doi.org/10.1371/journal.pgen.1009920

Massively parallel reporter assays discover de novo exonic splicing mutants in paralogs of Autism genes

Christy L. Rhine, Christopher Neil, Jing Wang, Samantha Maguire, Luke Buerer, Mitchell Salomon, Ijeoma C. Meremikwu, Juliana Kim, Natasha T. Strande, William G. Fairbrother

PLOS Genetics: published January 20, 2022 | https://doi.org/10.1371/journal.pgen.1009884

Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population

Henry Sung-Ching Wong, Szu-Yi Tsai, Hou-Wei Chu, Min-Rou Lin, Gan-Hong Lin, Yu-Ting Tai, Chen-Yang Shen, Wei-Chiao Chang

PLOS Genetics: published January 20, 2022 | https://doi.org/10.1371/journal.pgen.1009952

Detection and characterization of genome-wide mutations in M1 vegetative cells of gamma-irradiated Arabidopsis

Satoshi Kitamura, Katsuya Satoh, Yutaka Oono

PLOS Genetics: published January 20, 2022 | https://doi.org/10.1371/journal.pgen.1009979

Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation

Reem Elorbany, Joshua M. Popp, Katherine Rhodes, Benjamin J. Strober, Kenneth Barr, Guanghao Qi, Yoav Gilad, Alexis Battle

PLOS Genetics: published January 21, 2022 | https://doi.org/10.1371/journal.pgen.1009666

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study

Bryony L. Hayes, Timothy Robinson, Siddhartha Kar, Katherine S. Ruth, Konstantinos K. Tsilidis, Timothy Frayling, Anna Murray, Richard M. Martin, Deborah A. Lawlor, Rebecca C. Richmond

PLOS Genetics: published January 21, 2022 | https://doi.org/10.1371/journal.pgen.1009887

Demography and selection analysis of the incipient adaptive radiation of a Hawaiian woody species

Ayako Izuno, Yusuke Onoda, Gaku Amada, Keito Kobayashi, Mana Mukai, Yuji Isagi, Kentaro K. Shimizu

PLOS Genetics: published January 21, 2022 | https://doi.org/10.1371/journal.pgen.1009987

The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship

Chamala Lama, Cameron R. Love, Hoa Nhu Le, Marium Waqar, Joseph L. Reeve, Jyoti Lama, Brigitte Dauwalder

PLOS Genetics: published January 25, 2022 | https://doi.org/10.1371/journal.pgen.1009519

The estimates of effective population size based on linkage disequilibrium are virtually unaffected by natural selection

Irene Novo, Enrique Santiago, Armando Caballero

PLOS Genetics: published January 25, 2022 | https://doi.org/10.1371/journal.pgen.1009764

Proline-specific aminopeptidase P prevents replication-associated genome instability

Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R. Brooks, R. Elwyn Isaac, Simon J. Boulton, Enrique Martinez-Perez

PLOS Genetics: published January 26, 2022 | https://doi.org/10.1371/journal.pgen.1010025

Predictability and parallelism in the contemporary evolution of hybrid genomes

Quinn K. Langdon, Daniel L. Powell, Bernard Kim, Shreya M. Banerjee, Cheyenne Payne, Tristram O. Dodge, Ben Moran, Paola Fascinetto-Zago, Molly Schumer

PLOS Genetics: published January 27, 2022 | https://doi.org/10.1371/journal.pgen.1009914

Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity

Andrew J. Grant, Dipender Gill, Paul D. W. Kirk, Stephen Burgess

PLOS Genetics: published January 27, 2022 | https://doi.org/10.1371/journal.pgen.1009975

The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function

Zhiyu Liu, Herong Shi, Jun Liu

PLOS Genetics: published January 28, 2022 | https://doi.org/10.1371/journal.pgen.1009936

Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components

Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M. Lambert, Ken C. Q. Nguyen, David H. Hall, Michael M. Francis

PLOS Genetics: published January 28, 2022 | https://doi.org/10.1371/journal.pgen.1010016

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Meta-imputation of transcriptome from genotypes across multiple datasets by leveraging publicly available summary-level data

Andrew E. Liu, Hyun Min Kang

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1009571

Transcription factor regulation of eQTL activity across individuals and tissues

Elise D. Flynn, Athena L. Tsu, Silva Kasela, Sarah Kim-Hellmuth, Francois Aguet, Kristin G. Ardlie, Harmen J. Bussemaker, Pejman Mohammadi, Tuuli Lappalainen

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1009719

The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless

Rui Chen, Xiaobing Deng, Sijun Zhu

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1009928

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Sherylanne Newton, Fanbo Kong, Adam J. Carlton, Carlos Aguilar, Andrew Parker, Gemma F. Codner, Lydia Teboul, Sara Wells, Steve D. M. Brown, Walter Marcotti, Michael R. Bowl

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1009937

Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types

Jia Wen, Taylor M. Lagler, Quan Sun, Yuchen Yang, Jiawen Chen, Yuriko Harigaya, Vijay G. Sankaran, Ming Hu, Alexander P. Reiner, Laura M. Raffield, Yun Li

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1009984

The Clock:Cycle complex is a major transcriptional regulator of Drosophila photoreceptors that protects the eye from retinal degeneration and oxidative stress

Juan Jauregui-Lozano, Hana Hall, Sarah C. Stanhope, Kimaya Bakhle, Makayla M. Marlin, Vikki M. Weake

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1010021

Redundant neural circuits regulate olfactory integration

Wenxing Yang, Taihong Wu, Shasha Tu, Yuang Qin, Chengchen Shen, Jiangyun Li, Myung-Kyu Choi, Fengyun Duan, Yun Zhang

PLOS Genetics: published January 31, 2022 | https://doi.org/10.1371/journal.pgen.1010029

Correction: The genetic consequences of dog breed formation—Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels

Erik Axelsson, Ingrid Ljungvall, Priyasma Bhoumik, Laura Bas Conn, Eva Muren, Åsa Ohlsson, Lisbeth Høier Olsen, Karolina Engdahl, Ragnvi Hagman, Jeanette Hanson, Dmytro Kryvokhyzha, Mats Pettersson, Olivier Grenet, Jonathan Moggs, Alberto Del Rio-Espinola, Christian Epe, Bruce Taillon, Nilesh Tawari, Shrinivas Mane, Troy Hawkins, Åke Hedhammar, Philippe Gruet, Jens Häggström, Kerstin Lindblad-Toh

PLOS Genetics: published January 27, 2022 | https://doi.org/10.1371/journal.pgen.1010039

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