The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

John Isaac Murray, Elicia Preston, Jeremy P. Crawford, Jonathan D. Rumley, Prativa Amom, Breana D. Anderson, Priya Sivaramakrishnan, Shaili D. Patel, Barrington Alexander Bennett, Teddy D. Lavon, Erin Hsiao, Felicia Peng, Amanda L. Zacharias

PLOS Genetics: published May 2, 2022 | https://doi.org/10.1371/journal.pgen.1010187

Assessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus

Kaho H. Tisthammer, Caroline Solis, Faye Orcales, Madu Nzerem, Ryan Winstead, Weiyan Dong, Jeffrey B. Joy, Pleuni S. Pennings

PLOS Genetics: published May 2, 2022 | https://doi.org/10.1371/journal.pgen.1010179

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila

Michaela Fenckova, Villo Muha, Daniel Mariappa, Marica Catinozzi, Ignacy Czajewski, Laura E. R. Blok, Andrew T. Ferenbach, Erik Storkebaum, Annette Schenck, Daan M. F. van Aalten

PLOS Genetics: published May 2, 2022 | https://doi.org/10.1371/journal.pgen.1010159

A practical problem with Egger regression in Mendelian randomization

Zhaotong Lin, Isaac Pan, Wei Pan

PLOS Genetics: published May 4, 2022 | https://doi.org/10.1371/journal.pgen.1010166

Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans

Molly A. Matty, Hiu E. Lau, Jessica A. Haley, Anupama Singh, Ahana Chakraborty, Karina Kono, Kirthi C. Reddy, Malene Hansen, Sreekanth H. Chalasani

PLOS Genetics: published May 5, 2022 | https://doi.org/10.1371/journal.pgen.1010178

Sex-heterogeneous SNPs disproportionately influence gene expression and health

Michela Traglia, Margaux Bout, Lauren A. Weiss

PLOS Genetics: published May 5, 2022 | https://doi.org/10.1371/journal.pgen.1010147

Dnmt1a is essential for gene body methylation and the regulation of the zygotic genome in a wasp

Deanna Arsala, Xin Wu, Soojin V. Yi, Jeremy A. Lynch

PLOS Genetics: published May 6, 2022 | https://doi.org/10.1371/journal.pgen.1010181

Polygenic score accuracy in ancient samples: Quantifying the effects of allelic turnover

Maryn O. Carlson, Daniel P. Rice, Jeremy J. Berg, Matthias Steinrücken

PLOS Genetics: published May 6, 2022 | https://doi.org/10.1371/journal.pgen.1010170

Elucidation of host and symbiont contributions to peptidoglycan metabolism based on comparative genomics of eight aphid subfamilies and their Buchnera

Thomas E. Smith, Yiyuan Li, Julie Perreau, Nancy A. Moran

PLOS Genetics: published May 6, 2022 | https://doi.org/10.1371/journal.pgen.1010195

RecombineX: A generalized computational framework for automatic high-throughput gamete genotyping and tetrad-based recombination analysis

Jing Li, Bertrand Llorente, Gianni Liti, Jia-Xing Yue

PLOS Genetics: published May 9, 2022 | https://doi.org/10.1371/journal.pgen.1010047

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction

Dusanka Milenkovic, Adrián Sanz-Moreno, Julia Calzada-Wack, Birgit Rathkolb, Oana Veronica Amarie, Raffaele Gerlini, Antonio Aguilar-Pimentel, Jelena Misic, Marie-Lune Simard, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Nils-Göran Larsson

PLOS Genetics: published May 9, 2022 | https://doi.org/10.1371/journal.pgen.1010190

A Bayesian model selection approach to mediation analysis

Wesley L. Crouse, Gregory R. Keele, Madeleine S. Gastonguay, Gary A. Churchill, William Valdar

PLOS Genetics: published May 9, 2022 | https://doi.org/10.1371/journal.pgen.1010184

RADA-dependent branch migration has a predominant role in plant mitochondria and its defect leads to mtDNA instability and cell cycle arrest

Nicolas Chevigny, Frédérique Weber-Lotfi, Anaïs Le Blevenec, Cédric Nadiras, Arnaud Fertet, Marc Bichara, Mathieu Erhardt, André Dietrich, Cécile Raynaud, José M. Gualberto

PLOS Genetics: published May 12, 2022 | https://doi.org/10.1371/journal.pgen.1010202

A hominoid-specific endogenous retrovirus may have rewired the gene regulatory network shared between primordial germ cells and naïve pluripotent cells

Jumpei Ito, Yasunari Seita, Shohei Kojima, Nicholas F. Parrish, Kotaro Sasaki, Kei Sato

PLOS Genetics: published May 12, 2022 | https://doi.org/10.1371/journal.pgen.1009846

Shared genetic loci between depression and cardiometabolic traits

Kristin Torgersen, Zillur Rahman, Shahram Bahrami, Guy Frederick Lanyon Hindley, Nadine Parker, Oleksandr Frei, Alexey Shadrin, Kevin S. O’Connell, Martin Tesli, Olav B. Smeland, John Munkhaugen, Srdjan Djurovic, Toril Dammen, Ole A. Andreassen

PLOS Genetics: published May 13, 2022 | https://doi.org/10.1371/journal.pgen.1010161

Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis

Amy A. Eapen, Sreeja Parameswaran, Carmy Forney, Lee E. Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z. Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David I. Bernstein, Ashley L. Devonshire, Marc E. Rothenberg, Matthew T. Weirauch, Leah C. Kottyan

PLOS Genetics: published May 16, 2022 | https://doi.org/10.1371/journal.pgen.1009973

Structure and kinase activity of bacterial cell cycle regulator CcrZ

Katherine J. Wozniak, Peter E. Burby, Jayakrishnan Nandakumar, Lyle A. Simmons

PLOS Genetics: published May 16, 2022 | https://doi.org/10.1371/journal.pgen.1010196

Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data

Haoran Xue, Wei Pan

PLOS Genetics: published May 16, 2022 | https://doi.org/10.1371/journal.pgen.1010205

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes

Colin Kenny, Ramile Dilshat, Hannah E. Seberg, Eric Van Otterloo, Gregory Bonde, Annika Helverson, Christopher M. Franke, Eiríkur Steingrímsson, Robert A. Cornell

PLOS Genetics: published May 17, 2022 | https://doi.org/10.1371/journal.pgen.1010207

Related Articles

1. Correction: TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes

Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction

R. A. Greenstein, Henry Ng, Ramon R. Barrales, Catherine Tan, Sigurd Braun, Bassem Al-Sady

PLOS Genetics: published May 18, 2022 | https://doi.org/10.1371/journal.pgen.1010201

Biology and engineering of integrative and conjugative elements: Construction and analyses of hybrid ICEs reveal element functions that affect species-specific efficiencies

Emily L. Bean, Calvin Herman, Mary E. Anderson, Alan D. Grossman

PLOS Genetics: published May 18, 2022 | https://doi.org/10.1371/journal.pgen.1009998

MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

Meenalakshmi Chinnam, Chao Xu, Rati Lama, Xiaojing Zhang, Carlos D. Cedeno, Yanqing Wang, Aimee B. Stablewski, David W. Goodrich, Xinjiang Wang

PLOS Genetics: published May 19, 2022 | https://doi.org/10.1371/journal.pgen.1010171

Related Articles

1. Correction: MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent manner

Syed Zahid, Sarah Aloe, Jeanette H. Sutherland, William K. Holloman, Neal F. Lue

PLOS Genetics: published May 19, 2022 | https://doi.org/10.1371/journal.pgen.1010182

Increased genetic contribution to wellbeing during the COVID-19 pandemic

C. A. Robert Warmerdam, Henry H. Wiersma, Pauline Lanting, Alireza Ani, Lifelines Corona Research Initiative, Lifelines Cohort Study, Marjolein X. L. Dijkema, Harold Snieder, Judith M. Vonk, H. Marike Boezen, Patrick Deelen, Lude H. Franke

PLOS Genetics: published May 19, 2022 | https://doi.org/10.1371/journal.pgen.1010135

A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila

Aarthi Kuppannan, Yu-Yang Jiang, Wolfgang Maier, Chang Liu, Charles F. Lang, Chao-Yin Cheng, Mark C. Field, Minglei Zhao, Martin Zoltner, Aaron P. Turkewitz

PLOS Genetics: published May 19, 2022 | https://doi.org/10.1371/journal.pgen.1010194

Crosstalk between guanosine nucleotides regulates cellular heterogeneity in protein synthesis during nutrient limitation

Simon Diez, Molly Hydorn, Abigail Whalen, Jonathan Dworkin

PLOS Genetics: published May 20, 2022 | https://doi.org/10.1371/journal.pgen.1009957

PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans

Guillaume Bordet, Carole Couillault, Fabien Soulavie, Konstantina Filippopoulou, Vincent Bertrand

PLOS Genetics: published May 23, 2022 | https://doi.org/10.1371/journal.pgen.1010209

Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs

Line Manceau, Julien Richard Albert, Pier-Luigi Lollini, Maxim V. C. Greenberg, Pascale Gilardi-Hebenstreit, Vanessa Ribes

PLOS Genetics: published May 23, 2022 | https://doi.org/10.1371/journal.pgen.1009782

Population bottlenecks constrain host microbiome diversity and genetic variation impeding fitness

Michael Ørsted, Erika Yashiro, Ary A. Hoffmann, Torsten Nygaard Kristensen

PLOS Genetics: published May 23, 2022 | https://doi.org/10.1371/journal.pgen.1010206

Early midcell localization of Escherichia coli PBP4 supports the function of peptidoglycan amidases

Jolanda Verheul, Adam Lodge, Hamish C. L. Yau, Xiaolong Liu, Gabriela Boelter, Xinwei Liu, Alexandra S. Solovyova, Athanasios Typas, Manuel Banzhaf, Waldemar Vollmer, Tanneke den Blaauwen

PLOS Genetics: published May 23, 2022 | https://doi.org/10.1371/journal.pgen.1010222

Genome size distributions in bacteria and archaea are strongly linked to evolutionary history at broad phylogenetic scales

Carolina A. Martinez-Gutierrez, Frank O. Aylward

PLOS Genetics: published May 23, 2022 | https://doi.org/10.1371/journal.pgen.1010220

Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila

Weihua Li, Jennifer S. Trigg, Paul H. Taghert

PLOS Genetics: published May 23, 2022 | https://doi.org/10.1371/journal.pgen.1010013

Competence shut-off by intracellular pheromone degradation in salivarius streptococci

Adrien Knoops, Laura Ledesma-García, Alexandra Waegemans, Morgane Lamontagne, Baptiste Decat, Hervé Degand, Pierre Morsomme, Patrice Soumillion, Frank Delvigne, Pascal Hols

PLOS Genetics: published May 25, 2022 | https://doi.org/10.1371/journal.pgen.1010198

Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility

Rebecca C. Lowry, Zachary F. Hallberg, Rob Till, Tyler J. Simons, Ruth Nottingham, Fiona Want, R. Elizabeth Sockett, Ming C. Hammond, Carey Lambert

PLOS Genetics: published May 27, 2022 | https://doi.org/10.1371/journal.pgen.1010164

Related Articles

1. Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP—AMP to control predation in Bdellovibrio bacteriovorus

Shade suppresses wound-induced leaf repositioning through a mechanism involving PHYTOCHROME KINASE SUBSTRATE (PKS) genes

Anne-Sophie Fiorucci, Olivier Michaud, Emanuel Schmid-Siegert, Martine Trevisan, Laure Allenbach Petrolati, Yetkin Çaka Ince, Christian Fankhauser

PLOS Genetics: published May 27, 2022 | https://doi.org/10.1371/journal.pgen.1010213

Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants

Cassidy Hemphill, Evye Pylarinou-Sinclair, Omar Itani, Barbara Scott, C. Michael Crowder, Marc Ryan Van Gilst

PLOS Genetics: published May 27, 2022 | https://doi.org/10.1371/journal.pgen.1009672

An unexpected role for the conserved ADAM-family metalloprotease ADM-2 in Caenorhabditis elegans molting

Braveen B. Joseph, Phillip T. Edeen, Sarina Meadows, Shaonil Binti, David S. Fay

PLOS Genetics: published May 31, 2022 | https://doi.org/10.1371/journal.pgen.1010249

Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies

Alexander F. Gileta, Christopher J. Fitzpatrick, Apurva S. Chitre, Celine L. St. Pierre, Elizabeth V. Joyce, Rachael J. Maguire, Africa M. McLeod, Natalia M. Gonzales, April E. Williams, Jonathan D. Morrow, Terry E. Robinson, Shelly B. Flagel, Abraham A. Palmer

PLOS Genetics: published May 31, 2022 | https://doi.org/10.1371/journal.pgen.1010234

Major sex differences in allele frequencies for X chromosomal variants in both the 1000 Genomes Project and gnomAD

Zhong Wang, Lei Sun, Andrew D. Paterson

PLOS Genetics: published May 31, 2022 | https://doi.org/10.1371/journal.pgen.1010231

Correction: Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis

Pablo Pulido, Ernesto Llamas, Briardo Llorente, Salvador Ventura, Louwrance P. Wright, Manuel Rodríguez-Concepción

PLOS Genetics: published May 9, 2022 | https://doi.org/10.1371/journal.pgen.1010216

Related Articles

1. Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis

Correction: Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

The PLOS Genetics Staff

PLOS Genetics: published May 24, 2022 | https://doi.org/10.1371/journal.pgen.1010242

Related Articles

1. Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

Perspectives on rigor and reproducibility in single cell genomics

Greg Gibson

PLOS Genetics: published May 10, 2022 | https://doi.org/10.1371/journal.pgen.1010210