Selective sweeps on different pigmentation genes mediate convergent evolution of island melanism in two incipient bird species

Leonardo Campagna, Ziyi Mo, Adam Siepel, J. Albert C. Uy

PLOS Genetics: published November 1, 2022 | https://doi.org/10.1371/journal.pgen.1010474

COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection

Yuxuan Wang, Suri Guga, Kejia Wu, Zoe Khaw, Konstantinos Tzoumkas, Phil Tombleson, Mary E. Comeau, Carl D. Langefeld, Deborah S. Cunninghame Graham, David L. Morris, Timothy J. Vyse

PLOS Genetics: published November 3, 2022 | https://doi.org/10.1371/journal.pgen.1010253

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

Guillaume Butler-Laporte, Gundula Povysil, Jack A. Kosmicki, Elizabeth T. Cirulli, Theodore Drivas, Simone Furini, Chadi Saad, Axel Schmidt, Pawel Olszewski, Urszula Korotko, Mathieu Quinodoz, Elifnaz Çelik, Kousik Kundu, Klaudia Walter, Junghyun Jung, Amy D. Stockwell, Laura G. Sloofman, Daniel M. Jordan, Ryan C. Thompson, Diane Del Valle, Nicole Simons, Esther Cheng, Robert Sebra, Eric E. Schadt, Seunghee Kim-Schulze, Sacha Gnjatic, Miriam Merad, Joseph D. Buxbaum, Noam D. Beckmann, Alexander W. Charney, Bartlomiej Przychodzen, Timothy Chang, Tess D. Pottinger, Ning Shang, Fabian Brand, Francesca Fava, Francesca Mari, Karolina Chwialkowska, Magdalena Niemira, Szymon Pula, J Kenneth Baillie, Alex Stuckey, Antonio Salas, Xabier Bello, Jacobo Pardo-Seco, Alberto Gómez-Carballa, Irene Rivero-Calle, Federico Martinón-Torres, Andrea Ganna, Konrad J. Karczewski, Kumar Veerapen, Mathieu Bourgey, Guillaume Bourque, Robert JM Eveleigh, Vincenzo Forgetta, David Morrison, David Langlais, Mark Lathrop, Vincent Mooser, Tomoko Nakanishi, Robert Frithiof, Michael Hultström, Miklos Lipcsey, Yanara Marincevic-Zuniga, Jessica Nordlund, Kelly M. Schiabor Barrett, William Lee, Alexandre Bolze, Simon White, Stephen Riffle, Francisco Tanudjaja, Efren Sandoval, Iva Neveux, Shaun Dabe, Nicolas Casadei, Susanne Motameny, Manal Alaamery, Salam Massadeh, Nora Aljawini, Mansour S. Almutairi, Yaseen M. Arabi, Saleh A. Alqahtani, Fawz S. Al Harthi, Amal Almutairi, Fatima Alqubaishi, Sarah Alotaibi, Albandari Binowayn, Ebtehal A. Alsolm, Hadeel El Bardisy, Mohammad Fawzy, Fang Cai, Nicole Soranzo, Adam Butterworth, COVID-19 Host Genetics Initiative, DeCOI Host Genetics Group, GEN-COVID Multicenter Study (Italy), Mount Sinai Clinical Intelligence Center, GEN-COVID consortium (Spain), GenOMICC Consortium, Japan COVID-19 Task Force, Regeneron Genetics Center, Daniel H. Geschwind, Stephanie Arteaga, Alexis Stephens, Manish J. Butte, Paul C. Boutros, Takafumi N. Yamaguchi, Shu Tao, Stefan Eng, Timothy Sanders, Paul J. Tung, Michael E. Broudy, Yu Pan, Alfredo Gonzalez, Nikhil Chavan, Ruth Johnson, Bogdan Pasaniuc, Brian Yaspan, Sandra Smieszek, Carlo Rivolta, Stephanie Bibert, Pierre-Yves Bochud, Maciej Dabrowski, Pawel Zawadzki, Mateusz Sypniewski, Elżbieta Kaja, Pajaree Chariyavilaskul, Voraphoj Nilaratanakul, Nattiya Hirankarn, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Katsushi Tokunaga, Masaya Sugiyama, Yosuke Kawai, Takanori Hasegawa, Tatsuhiko Naito, Ho Namkoong, Ryuya Edahiro, Akinori Kimura, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Seiya Imoto, Satoru Miyano, Serghei Mangul, Malak S. Abedalthagafi, Hugo Zeberg, Joseph J. Grzymski, Nicole L. Washington, Stephan Ossowski, Kerstin U. Ludwig, Eva C. Schulte, Olaf Riess, Marcin Moniuszko, Miroslaw Kwasniewski, Hamdi Mbarek, Said I. Ismail, Anurag Verma, David B. Goldstein, Krzysztof Kiryluk, Alessandra Renieri, Manuel A. R. Ferreira, J Brent Richards

PLOS Genetics: published November 3, 2022 | https://doi.org/10.1371/journal.pgen.1010367

Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations

Kodi Taraszka, Noah Zaitlen, Eleazar Eskin

PLOS Genetics: published November 7, 2022 | https://doi.org/10.1371/journal.pgen.1010447

Trans-regulatory changes underpin the evolution of the Drosophila immune response

Shuai Dominique Ding, Alexandre B. Leitão, Jonathan P. Day, Ramesh Arunkumar, Morgan Phillips, Shuyu Olivia Zhou, Francis M. Jiggins

PLOS Genetics: published November 7, 2022 | https://doi.org/10.1371/journal.pgen.1010453

Aging and sperm signals alter DNA break formation and repair in the C. elegans germline

Erik Toraason, Victoria L. Adler, Diana E. Libuda

PLOS Genetics: published November 7, 2022 | https://doi.org/10.1371/journal.pgen.1010282

Mosaic patterns of selection in genomic regions associated with diverse human traits

Abin Abraham, Abigail L. LaBella, John A. Capra, Antonis Rokas

PLOS Genetics: published November 7, 2022 | https://doi.org/10.1371/journal.pgen.1010494

Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans

Bruno Hernandez-Cravero, Sofia Gallino, Jeremy Florman, Cecilia Vranych, Philippe Diaz, Ana Belén Elgoyhen, Mark J. Alkema, Diego de Mendoza

PLOS Genetics: published November 8, 2022 | https://doi.org/10.1371/journal.pgen.1010346

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

Claire J. Watson, W. Joyce Tang, Maria F. Rojas, Imke A. K. Fiedler, Ernesto Morfin Montes de Oca, Andrea R. Cronrath, Lulu K. Callies, Avery Angell Swearer, Ali R. Ahmed, Visali Sethuraman, Sumaya Addish, Gist H. Farr III, Arianna Ericka Gómez, Jyoti Rai, Adrian T. Monstad-Rios, Edith M. Gardiner, David Karasik, Lisa Maves, Bjorn Busse, Yi-Hsiang Hsu, Ronald Young Kwon

PLOS Genetics: published November 8, 2022 | https://doi.org/10.1371/journal.pgen.1010496

Ydj1 interaction at nucleotide-binding-domain of yeast Ssa1 impacts Hsp90 collaboration and client maturation

Deepika Gaur, Navinder Kumar, Abhirupa Ghosh, Prashant Singh, Pradeep Kumar, Jyoti Guleria, Satinderdeep Kaur, Nikhil Malik, Sudipto Saha, Thomas Nystrom, Deepak Sharma

PLOS Genetics: published November 9, 2022 | https://doi.org/10.1371/journal.pgen.1010442

A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates human axonopathy and suggest alteration in axo-glia communication

Ghjuvan’Ghjacumu Shackleford, Leandro N. Marziali, Yo Sasaki, Anke Claessens, Cinzia Ferri, Nadav I. Weinstock, Alexander M. Rossor, Nicholas J. Silvestri, Emma R. Wilson, Edward Hurley, Grahame J. Kidd, Senthilvelan Manohar, Dalian Ding, Richard J. Salvi, M. Laura Feltri, Maurizio D’Antonio, Lawrence Wrabetz

PLOS Genetics: published November 9, 2022 | https://doi.org/10.1371/journal.pgen.1010477

ATRX modulates the escape from a telomere crisis

Helene E. B. Geiller, Adam Harvey, Rhiannon E. Jones, Julia W. Grimstead, Kez Cleal, Eric A. Hendrickson, Duncan M. Baird

PLOS Genetics: published November 9, 2022 | https://doi.org/10.1371/journal.pgen.1010485

Light triggers a network switch between circadian morning and evening oscillators controlling behaviour during daily temperature cycles

Clara Lorber, Solene Leleux, Ralf Stanewsky, Angelique Lamaze

PLOS Genetics: published November 11, 2022 | https://doi.org/10.1371/journal.pgen.1010487

The Rheb GTPase promotes pheromone blindness via a TORC1-independent pathway in the phytopathogenic fungus Ustilago maydis

Antonio de la Torre, José Pérez-Martín

PLOS Genetics: published November 14, 2022 | https://doi.org/10.1371/journal.pgen.1010483

Trans-driven variation in expression is common among detoxification genes in the extreme generalist herbivore Tetranychus urticae

Andre H. Kurlovs, Berdien De Beer, Meiyuan Ji, Marilou Vandenhole, Tim De Meyer, René Feyereisen, Richard M. Clark, Thomas Van Leeuwen

PLOS Genetics: published November 14, 2022 | https://doi.org/10.1371/journal.pgen.1010333

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability

Estelle Simo Cheyou, Jacopo Boni, Jonathan Boulais, Edgar Pinedo-Carpio, Abba Malina, Dana Sherill-Rofe, Vincent M. Luo, Christophe Goncalves, Halil Bagci, Alexandra Maters, Raquel Cuella-Martin, Yuval Tabach, Sonia del Rincon, Jean-Francois Côté, Barbara Rivera, Alexandre Orthwein

PLOS Genetics: published November 14, 2022 | https://doi.org/10.1371/journal.pgen.1010495

O-GlcNAc transferase plays a non-catalytic role in C. elegans male fertility

Daniel Konzman, Tetsunari Fukushige, Mesgana Dagnachew, Michael Krause, John A. Hanover

PLOS Genetics: published November 16, 2022 | https://doi.org/10.1371/journal.pgen.1010273

Predictable and stable epimutations induced during clonal plant propagation with embryonic transcription factor

Anjar Tri Wibowo, Javier Antunez-Sanchez, Alexander Dawson, Jonathan Price, Cathal Meehan, Travis Wrightsman, Maximillian Collenberg, Ilja Bezrukov, Claude Becker, Moussa Benhamed, Detlef Weigel, Jose Gutierrez-Marcos

PLOS Genetics: published November 16, 2022 | https://doi.org/10.1371/journal.pgen.1010479

Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia

Rosie Clark, Alfred Pozarickij, Pirro G. Hysi, Kyoko Ohno-Matsui, Cathy Williams, Jeremy A. Guggenheim, UK Biobank Eye and Vision Consortium

PLOS Genetics: published November 17, 2022 | https://doi.org/10.1371/journal.pgen.1010478

Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors

Elizabeth M. Knapp, Andrea Kaiser, Rebecca C. Arnold, Maureen M. Sampson, Manuela Ruppert, Li Xu, Matthew I. Anderson, Shivan L. Bonanno, Henrike Scholz, Jeffrey M. Donlea, David E. Krantz

PLOS Genetics: published November 21, 2022 | https://doi.org/10.1371/journal.pgen.1010289

The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1

Nathan C. Fischer, Vladislav Friedman, Miguel A. Martinez-Reyes, Hongyan Hao, Tamjid A. Chowdhury, Daniel A. Starr, Christopher C. Quinn

PLOS Genetics: published November 21, 2022 | https://doi.org/10.1371/journal.pgen.1010521

MYB44-ENAP1/2 restricts HDT4 to regulate drought tolerance in Arabidopsis

Bo Zhao, Zhengyao Shao, Likai Wang, Fan Zhang, Daveraj Chakravarty, Wei Zong, Juan Dong, Liang Song, Hong Qiao

PLOS Genetics: published November 22, 2022 | https://doi.org/10.1371/journal.pgen.1010473

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes

Amanda J. Stock, Ross A. McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G. Becker, Elin Lehrmann, William H. Wood 3rd, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu

PLOS Genetics: published November 28, 2022 | https://doi.org/10.1371/journal.pgen.1010506

TGFβ pathway is required for viable gestation of Fanconi anemia embryos

Alfredo Rodríguez, Michael Epperly, Jessica Filiatrault, Martha Velázquez, Chunyu Yang, Kelsey McQueen, Larissa A. Sambel, Huy Nguyen, Divya Ramalingam Iyer, Ulises Juárez, Cecilia Ayala-Zambrano, David B. Martignetti, Sara Frías, Renee Fisher, Kalindi Parmar, Joel S. Greenberger, Alan D. D’Andrea

PLOS Genetics: published November 28, 2022 | https://doi.org/10.1371/journal.pgen.1010459

Rice OsPUB16 modulates the ‘SAPK9-OsMADS23-OsAOC’ pathway to reduce plant water-deficit tolerance by repressing ABA and JA biosynthesis

Qianlong Lv, Xingxing Li, Xinkai Jin, Ying Sun, Yuanyuan Wu, Wanmin Wang, Junli Huang

PLOS Genetics: published November 28, 2022 | https://doi.org/10.1371/journal.pgen.1010520

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay

Antonia M. G. van den Elzen, Maegan J. Watson, Carson C. Thoreen

PLOS Genetics: published November 28, 2022 | https://doi.org/10.1371/journal.pgen.1010532

A widespread inversion polymorphism conserved among Saccharomyces species is caused by recurrent homogenization of a sporulation gene family

Letal I. Salzberg, Alexandre A. R. Martos, Lisa Lombardi, Lars S. Jermiin, Alfonso Blanco, Kevin P. Byrne, Kenneth H. Wolfe

PLOS Genetics: published November 28, 2022 | https://doi.org/10.1371/journal.pgen.1010525

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression

Jennifer M. Luppino, Andrew Field, Son C. Nguyen, Daniel S. Park, Parisha P. Shah, Richard J. Abdill, Yemin Lan, Rebecca Yunker, Rajan Jain, Karen Adelman, Eric F. Joyce

PLOS Genetics: published November 30, 2022 | https://doi.org/10.1371/journal.pgen.1010528

Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis

Steven J. Grzegorski, Yakun Zhao, Catherine E. Richter, Chia-Jui Ku, Kari I. Lavik, Divyani Paul, James H. Morrissey, Jordan A. Shavit

PLOS Genetics: published November 30, 2022 | https://doi.org/10.1371/journal.pgen.1010534

ZYG-9^ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis

Gabriel Cavin-Meza, Timothy J. Mullen, Emily R. Czajkowski, Ian D. Wolff, Nikita S. Divekar, Justin D. Finkle, Sarah M. Wignall

PLOS Genetics: published November 30, 2022 | https://doi.org/10.1371/journal.pgen.1010489

Retraction: Maize opaque10 Encodes a Cereal-Specific Protein That Is Essential for the Proper Distribution of Zeins in Endosperm Protein Bodies

The PLOS Genetics Editors

PLOS Genetics: published November 16, 2022 | https://doi.org/10.1371/journal.pgen.1010501

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1. Maize opaque10 Encodes a Cereal-Specific Protein That Is Essential for the Proper Distribution of Zeins in Endosperm Protein Bodies

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables

Julian Hecker, Dmitry Prokopenko, Matthew Moll, Sanghun Lee, Wonji Kim, Dandi Qiao, Kirsten Voorhies, Woori Kim, Stijn Vansteelandt, Brian D. Hobbs, Michael H. Cho, Edwin K. Silverman, Sharon M. Lutz, Dawn L. DeMeo, Scott T. Weiss, Christoph Lange

PLOS Genetics: published November 16, 2022 | https://doi.org/10.1371/journal.pgen.1010464