(Q14916288)

http://www.ebi.ac.uk/interpro/protein/P48540

Cystine-knot cytokine

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48540

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein homodimerization activity

transforming growth factor beta receptor binding

1 reference

9 May 2019

A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

TAS

growth factor activity

glial cell-derived neurotrophic factor receptor binding

3 references

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

receptor tyrosine kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

receptor ligand activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

growth factor activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

Defects in enteric innervation and kidney development in mice lacking GDNF

biological process

ureteric bud formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

positive regulation of branching involved in ureteric bud morphogenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

14 February 2019

The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

nervous system development

1 reference

9 May 2019

Renal and neuronal abnormalities in mice lacking GDNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

postganglionic parasympathetic fiber development

1 reference

9 May 2019

Defects in enteric innervation and kidney development in mice lacking GDNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

transforming growth factor beta receptor signaling pathway

1 reference

9 May 2019

A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

postsynaptic membrane organization

TAS

1 reference

9 May 2019

Glia cell line-derived neurotrophic factor regulates the distribution of acetylcholine receptors in mouse primary skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

branching involved in ureteric bud morphogenesis

IDA

3 references

9 May 2019

Defects in enteric innervation and kidney development in mice lacking GDNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

IDA

1 reference

9 May 2019

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

positive regulation of monooxygenase activity

positive regulation of ureteric bud formation

positive regulation of transcription by RNA polymerase II

sympathetic nervous system development

1 reference

9 May 2019

Renal and neuronal abnormalities in mice lacking GDNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

Renal and neuronal abnormalities in mice lacking GDNF

metanephros development

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

1 reference

9 May 2019

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

neural crest cell migration

IGI

regulation of dopamine uptake involved in synaptic transmission

negative regulation of neuron apoptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

14 February 2019

Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

9 May 2019

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

neuron projection development

TAS

regulation of morphogenesis of a branching structure

1 reference

9 May 2019

Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

regulation of signaling receptor activity

IDA

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

cellular response to dexamethasone stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

regulation of ureteric bud formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

dorsal spinal cord development

1 reference

9 May 2019

gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

embryonic organ development

1 reference

9 May 2019

gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

commissural neuron axon guidance

1 reference

9 May 2019

gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

neural crest cell migration involved in autonomic nervous system development

IGI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

regulation of semaphorin-plexin signaling pathway

1 reference

9 May 2019

gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

peripheral nervous system development

IGI

3 references

9 May 2019

Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

negative regulation of neuron apoptotic process

IBA

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

positive regulation of branching involved in ureteric bud morphogenesis

IBA

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48540

Transforming growth factor-beta, C-terminal

IBA

has part(s)

1 reference

stated in

InterPro Release 71.0