(Q21115046)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28221

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

G protein-coupled serotonin receptor activity

4 references

5 June 2018

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

5 June 2018

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

4 references

8 April 2019

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

2 references

integral component of plasma membrane

3 references

5 June 2018

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

5 June 2018

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

integral component of plasma membrane

4 references

8 April 2019

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

intestine smooth muscle contraction

biological process

1 reference

8 April 2019

5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

IMP

regulation of locomotion

1 reference

8 April 2019

smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

5 June 2018

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

TAS

regulation of behavior

1 reference

8 April 2019

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

response to toxic substance

IMP

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28221&geneProductId=UniProtKB:P28221

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

G protein-coupled serotonin receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

chemical synaptic transmission

TAS

3 references

8 April 2019

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28221

physically interacts with

1 reference

149

17 August 2016

1 reference

7191

17 August 2016

1 reference

3

17 August 2016

1 reference

218

17 August 2016

5-carboxamidotryptamine

1 reference

4

17 August 2016

1 reference

5

17 August 2016

1 reference

107

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

2 references

7

17 August 2016

31

17 August 2016

2 references

120

17 August 2016

117

17 August 2016

1 reference

152

17 August 2016

1 reference

34

17 August 2016

1 reference

109

17 August 2016

1 reference

38

17 August 2016

1 reference

110

17 August 2016

1 reference

121

17 August 2016

1 reference

141

17 August 2016

1 reference

39

17 August 2016

1 reference

40

17 August 2016

1 reference

12

17 August 2016

1 reference

139

17 August 2016

1 reference

123

17 August 2016

1 reference

45

17 August 2016

1 reference

47

17 August 2016

1 reference

50

17 August 2016

1 reference

51

17 August 2016

1 reference

23

17 August 2016

1 reference

54

1-(3-trifluoromethylphenyl)piperazine

17 August 2016

1 reference

115

17 August 2016

1 reference

125

17 August 2016

1 reference

57

17 August 2016

1 reference

59

17 August 2016

1 reference

60

17 August 2016

1 reference

10

17 August 2016

1 reference

35

17 August 2016

1 reference

37

17 August 2016

1 reference

14

17 August 2016

1 reference

43

17 August 2016

1 reference

124

17 August 2016

1 reference

48

17 August 2016

1 reference

52

17 August 2016

1 reference

28

17 August 2016

1 reference

56

17 August 2016

1 reference

144

17 August 2016

1 reference

132

17 August 2016

1 reference

85

17 August 2016

1 reference

86

17 August 2016

m-chlorophenylpiperazine

antagonist

1 reference

142

17 August 2016

1 reference

88

17 August 2016

1 reference

133

17 August 2016

1 reference

134

17 August 2016

1 reference

46

17 August 2016

1 reference

92

17 August 2016

1 reference

136

17 August 2016

1 reference

96

17 August 2016

1 reference

97

17 August 2016

1 reference

143

17 August 2016

1 reference

98

17 August 2016

1 reference

99

17 August 2016

1 reference

102

17 August 2016

1 reference

103

17 August 2016

1 reference

89

17 August 2016

sumatriptan succinate

object has role

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201150

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1742428

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL37744

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL905

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1185

naratriptan hydrochloride

object has role

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200601

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0