Scandinavian Journal of Infectious Diseases, Jul 17, 2012
Prevalence data on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in Sweden have not been up... more Prevalence data on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in Sweden have not been updated since 1995. The seroprevalence among blood donors at that time was 0.2/10,000. A few years earlier, a high prevalence of HTLV-2 was found in intravenous drug users (IDUs) in Stockholm (3.4%). The objective of this study was to update information on the seroprevalence of HTLV in several study groups. Serum samples from pregnant women, hepatitis C virus (HCV)-positive individuals, and IDUs in Stockholm were investigated for HTLV-1/2 antibodies. Data from the mandatory HTLV-1/2 screening (2003-2006) of in vitro fertilization (IVF) clients were compiled, as well as data from new blood donors. Eight out of 35,000 IVF patients were positive for anti-HTLV-1/2 (seroprevalence 2.3 per 10,000). Of the anti-HCV-positive individuals (n = 355), 1 sample was HTLV-1-positive (28.2 per 10,000). From 1995 to 2007, 18 HTLV-positive new blood donors were identified out of approximately 550,000 individuals tested (0.3 per 10,000). Thirty-five of 1079 tested IDUs were screening reactive. Since the start of screening in 1994, there has been no increased seroprevalence of HTLV-1/2 among blood donors in Sweden. Seroprevalence among Swedish IVF patients is 10 times higher than among blood donors. This finding is comparable to a 2003 European seroprevalence study of pregnant women in 7 countries. However, the possibility that the IVF group includes individuals with a higher risk of acquiring sexually transmitted infections, including HTLV, than the general population cannot be ruled out.
Prevalence, phenotypic and genotypic characterisation of Neisseria meningitidis comprising reduce... more Prevalence, phenotypic and genotypic characterisation of Neisseria meningitidis comprising reduced susceptibility or resistance to rifampicin and/or ciprofloxacin in Sweden
Sequencing of the porB gene of Neisseria gonorrhoeae (Ng); sequence variability inventory and com... more Sequencing of the porB gene of Neisseria gonorrhoeae (Ng); sequence variability inventory and comparative alignments for cluster confirmation.
... 1, 2, Björn Herrmann 3, Markus Klint 3, Tomas Morin 3, Sara Ödmark 3, Linus Christerson 3 ...... more ... 1, 2, Björn Herrmann 3, Markus Klint 3, Tomas Morin 3, Sara Ödmark 3, Linus Christerson 3 ... Microbiology 2, Örebro University Hospital, SE-70185 Örebro, Department of Clinical Microbiology 3, University Hospital, SE ... In contrast all nvCT isolates (n=41) displayed an identical ST. ...
Human gene variants that regulate the NLRP3 activity limit the production of Neisseria meningitid... more Human gene variants that regulate the NLRP3 activity limit the production of Neisseria meningitidis-induced IL-1β and IL-18
European Journal of Clinical Microbiology & Infectious Diseases, Apr 1, 2005
ABSTRACT In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (... more ABSTRACT In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and genotypically characterized to investigate whether one or more PIP-negative strains are circulating in the Danish community. The profiles of these isolates were compared with those of three isolates from a recent outbreak of PIP-negative N. gonorrhoeae infection in the UK. Twenty-five of the Danish isolates and all three UK isolates had similar antibiograms and were designated serovar IB-4. Genotypic characterization by pulsed-field gel electrophoresis, porB1b gene sequencing, and opa-typing revealed that these isolates were indistinguishable or closely related. The results indicate that at least one PIP-negative N. gonorrhoeae strain is currently circulating in the Danish community, and this strain is indistinguishable from the one that caused an outbreak in the UK.
Scandinavian Journal of Infectious Diseases, Jul 17, 2012
Prevalence data on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in Sweden have not been up... more Prevalence data on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in Sweden have not been updated since 1995. The seroprevalence among blood donors at that time was 0.2/10,000. A few years earlier, a high prevalence of HTLV-2 was found in intravenous drug users (IDUs) in Stockholm (3.4%). The objective of this study was to update information on the seroprevalence of HTLV in several study groups. Serum samples from pregnant women, hepatitis C virus (HCV)-positive individuals, and IDUs in Stockholm were investigated for HTLV-1/2 antibodies. Data from the mandatory HTLV-1/2 screening (2003-2006) of in vitro fertilization (IVF) clients were compiled, as well as data from new blood donors. Eight out of 35,000 IVF patients were positive for anti-HTLV-1/2 (seroprevalence 2.3 per 10,000). Of the anti-HCV-positive individuals (n = 355), 1 sample was HTLV-1-positive (28.2 per 10,000). From 1995 to 2007, 18 HTLV-positive new blood donors were identified out of approximately 550,000 individuals tested (0.3 per 10,000). Thirty-five of 1079 tested IDUs were screening reactive. Since the start of screening in 1994, there has been no increased seroprevalence of HTLV-1/2 among blood donors in Sweden. Seroprevalence among Swedish IVF patients is 10 times higher than among blood donors. This finding is comparable to a 2003 European seroprevalence study of pregnant women in 7 countries. However, the possibility that the IVF group includes individuals with a higher risk of acquiring sexually transmitted infections, including HTLV, than the general population cannot be ruled out.
Prevalence, phenotypic and genotypic characterisation of Neisseria meningitidis comprising reduce... more Prevalence, phenotypic and genotypic characterisation of Neisseria meningitidis comprising reduced susceptibility or resistance to rifampicin and/or ciprofloxacin in Sweden
Sequencing of the porB gene of Neisseria gonorrhoeae (Ng); sequence variability inventory and com... more Sequencing of the porB gene of Neisseria gonorrhoeae (Ng); sequence variability inventory and comparative alignments for cluster confirmation.
... 1, 2, Björn Herrmann 3, Markus Klint 3, Tomas Morin 3, Sara Ödmark 3, Linus Christerson 3 ...... more ... 1, 2, Björn Herrmann 3, Markus Klint 3, Tomas Morin 3, Sara Ödmark 3, Linus Christerson 3 ... Microbiology 2, Örebro University Hospital, SE-70185 Örebro, Department of Clinical Microbiology 3, University Hospital, SE ... In contrast all nvCT isolates (n=41) displayed an identical ST. ...
Human gene variants that regulate the NLRP3 activity limit the production of Neisseria meningitid... more Human gene variants that regulate the NLRP3 activity limit the production of Neisseria meningitidis-induced IL-1β and IL-18
European Journal of Clinical Microbiology & Infectious Diseases, Apr 1, 2005
ABSTRACT In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (... more ABSTRACT In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and genotypically characterized to investigate whether one or more PIP-negative strains are circulating in the Danish community. The profiles of these isolates were compared with those of three isolates from a recent outbreak of PIP-negative N. gonorrhoeae infection in the UK. Twenty-five of the Danish isolates and all three UK isolates had similar antibiograms and were designated serovar IB-4. Genotypic characterization by pulsed-field gel electrophoresis, porB1b gene sequencing, and opa-typing revealed that these isolates were indistinguishable or closely related. The results indicate that at least one PIP-negative N. gonorrhoeae strain is currently circulating in the Danish community, and this strain is indistinguishable from the one that caused an outbreak in the UK.
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Papers by Hans Fredlund