Abstract
Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / metabolism*
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Anti-Infective Agents / pharmacology*
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Cholera / microbiology*
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DNA Gyrase / genetics
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DNA Gyrase / metabolism
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DNA Primers
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DNA Topoisomerase IV / genetics
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DNA Topoisomerase IV / metabolism
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Drug Resistance, Microbial
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Fluoroquinolones
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Genes, Bacterial / genetics
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Genome, Bacterial
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Humans
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Microbial Sensitivity Tests
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Mutation / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Vibrio cholerae / drug effects*
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Vibrio cholerae / genetics*
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Vibrio cholerae / metabolism
Substances
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Anti-Infective Agents
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DNA Primers
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Fluoroquinolones
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DNA Topoisomerase IV
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DNA Gyrase