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IFITM3-specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans

Eur J Immunol. 2021 Mar;51(3):742-745. doi: 10.1002/eji.202048706. Epub 2020 Dec 9.

Abstract

Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells.

Keywords: IFITM3; IFN; innate immunity; myeloid cells; viral restriction.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Antiviral Agents / metabolism*
  • CD4-Positive T-Lymphocytes / metabolism
  • Cell Line
  • Cell Line, Tumor
  • HEK293 Cells
  • Humans
  • Interferon Type I / metabolism*
  • Lymphocytes / metabolism
  • Membrane Proteins / metabolism*
  • RNA-Binding Proteins / metabolism*

Substances

  • Antiviral Agents
  • IFITM3 protein, human
  • Interferon Type I
  • Membrane Proteins
  • RNA-Binding Proteins