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Eyes on glutamate in angiogenesis and barrier formation

Neuron. 2024 Jun 19;112(12):1895-1897. doi: 10.1016/j.neuron.2024.05.020.

Abstract

In this issue of Neuron, Biswas et al.1 demonstrate the roles of glutamatergic neuronal activity in the regulation of angiogenesis and retinal vascular endothelial barrier maturation using three different knockout mouse models. Their findings shed light on how aberrant glutamatergic activity can impact neural vascular function and barrier integrity.

MeSH terms

  • Angiogenesis
  • Animals
  • Blood-Retinal Barrier / metabolism
  • Blood-Retinal Barrier / physiology
  • Glutamic Acid* / metabolism
  • Humans
  • Mice
  • Neovascularization, Physiologic / physiology
  • Retinal Vessels / metabolism

Substances

  • Glutamic Acid