Tracking defensive states with prefrontal dynorphin-expressing neurons

Thomas Bienvenu; Cyril Dejean; Cyril Herry

doi:10.1016/j.neuron.2024.05.028

Tracking defensive states with prefrontal dynorphin-expressing neurons

Neuron. 2024 Jun 19;112(12):1899-1901. doi: 10.1016/j.neuron.2024.05.028.

Authors

Thomas Bienvenu¹, Cyril Dejean², Cyril Herry³

Affiliations

¹ University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; Centre de Référence Régional des Pathologies Anxieuses et de la Dépression, Pôle de Psychiatrie Générale et Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France. Electronic address: [email protected].
² University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France.
³ University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France. Electronic address: [email protected].

PMID: 38901400
DOI: 10.1016/j.neuron.2024.05.028

Abstract

The dynamic suppression of threat-related behavior as a function of environmental constraint is critical for survival in mammals, yet the neurobiological underpinnings remain largely unknown. In this issue of Neuron, Wang et al.¹ identified prefrontal dynorphin-expressing neurons as key elements for tracking threat-related behavioral states and regulating fear suppression.

MeSH terms

Animals
Dynorphins* / metabolism
Fear* / physiology
Neurons* / metabolism
Prefrontal Cortex* / metabolism
Prefrontal Cortex* / physiology

Substances

Dynorphins