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ÍtemAcceso Abierto
El Trabajo Social y la política universitaria : un análisis de las prácticas en los Servicios Sociales Universitarios en la República Argentina
(Facultad de Ciencia Política y Relaciones Internacionales, 2024-07-31) Echevarría, Gastón; Ibáñez, Viviana; Rivas, Nicolás
La presente tesis doctoral se encuadra en el análisis de las prácticas profesionales de Trabajo Social, llevadas adelante en los Servicios Sociales de las universidades de la República Argentina. Este estudio se apoya en cinco categorías fundantes donde se inscribe, a nuestro entender el Trabajo Social: Estado, en su proceso de constitución hasta el denominado Estado moderno, Política, en relación al Trabajo Social en el campo de la política universitaria; Universidad, institución de la educación superior donde se asienta este estudio, y finalmente Asistencia, vinculado a la noción de derecho. La investigación se desarrolla desde un enfoque metodológico cualitativo para el análisis de las prácticas profesionales, con citas textuales que permiten ilustrar los escenarios de intervención del Trabajo Social. Para visualizar los aportes específicos que realiza el Trabajo Social a la política universitaria, buscamos anudar la primera parte, con la descripción y análisis de las prácticas profesionales de la segunda, en cuyo interior se alojaran las nociones conceptuales que hemos seleccionado para este estudio, Una especie de puente, entre el enfoque teórico y el análisis de las prácticas, un sendero por el cual caminar hacia la consolidación y legitimación del Trabajo Social. Las páginas finales contienen un entramado de reflexiones, que luego de este recorrido por un Trabajo Social a nivel federal, intenta reconstruir los valores y aportes específicos en el campo de la política universitaria, y liberar el terreno de prejuicios y representaciones sobre el ejercicio profesional del Trabajo Social.
ÍtemAcceso Abierto
La capoeira y su música en Rosario. Una aproximación etnográfica
(Universidad Nacional de Rosario. Escuela de Música, 2018) Bogado , Estefanía; Manias Toledo, Lucía; Buján, Federico; Federico
Como ciudadanas y estudiantes de la ciudad de Rosario, provincia de Santa Fe, Argentina, somos conscientes de la gran diversidad y pluralidad de actividades culturales que presenta nuestra ciudad. Dentro de esa compleja configuración multicultural, identificamos una manifestación cultural proveniente de Brasil conocida como Capoeira, la cual desarrolla los campos de lo espiritual, la danza, la educación física y lo musical. Indagando en diferentes fuentes (tesis, monografías y artículos académicos provenientes en su mayoría de Brasil) encontramos mucha información acerca del arte de la Capoeira. Si bien existen trabajos sobre el fenómeno en Rosario tienen otro enfoque y no hacen un relevamiento sobre el actual estado de la Capoeira en la ciudad. Frente a la situación planteada, hemos decidido estudiar este fenómeno a través de una investigación cualitativa, de tipo exploratorio y desde un enfoque etnográfico. Indagaremos sobre los orígenes y los campos culturales que involucra: dentro del campo musical investigaremos específicamente los métodos de enseñanza empleados en la ejecución instrumental y vocal, y cómo son puestos en práctica por los participantes. El análisis y los datos se obtendrán realizando un trabajo de campo realizado junto a distintas agrupaciones locales, mediante entrevistas y observaciones participantes. Dispondremos como fuente de información publicaciones de revistas de investigación y material audiovisual para otorgar sustento a nuestra propuesta.
ÍtemAcceso Abierto
Overexpression of Trypanosoma cruzi high mobility group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity
(Springer Nature, 2019-01-17) Tavernelli, Luis Emilio; Motta, María Cristina M.; Silva Gonçalves, Camila; Santos da Silva, Marcelo; Elías, María Carolina; Alonso, Victoria Lucía; Serra, Esteban Carlos; Cribb, Pamela; Dr. De Gaudenzi, Javier: provide the pTcINDEX-eGFP strain
Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly post-transcriptionally, chromatin accessibility plays a fundamental role in transcription initiation control. We have previously shown that High Mobility Group B protein from Trypanosoma cruzi (TcHMGB) can bind DNA in vitro. Here, we show that TcHMGB also acts as an architectural protein in vivo, since the overexpression of this protein induces changes in the nuclear structure, mainly the reduction of the nucleolus and a decrease in the heterochromatin:euchromatin ratio. Epimastigote replication rate was markedly reduced presumably due to a delayed cell cycle progression with accumulation of parasites in G2/M phase and impaired cytokinesis. Some functions involved in pathogenesis were also altered in TcHMGB-overexpressing parasites, like the decreased efficiency of trypomastigotes to infect cells in vitro, the reduction of intracellular amastigotes replication and the number of released trypomastigotes. Taken together, our results suggest that the TcHMGB protein is a pleiotropic player that controls cell phenotype and it is involved in key cellular processes.
ÍtemAcceso Abierto
Adenovirus-mediated human aquaporin-1 expression in hepatocytes improves lipopolysaccharide-induced cholestasis
(John Wiley & Sons Inc, 2017-12) Marrone, Julieta; Danielli, Mauro; Gaspari, César Ismael; Marinelli, Raúl A.; http://orcid.org/0000-0003-2934-8863
Lipopolysaccharides (LPS) are known to cause cholestasis in sepsis. There is evidence that a defective expression of canalicular aquaporin water channels contributes to bile secretory failure in LPS-induced cholestasis. Thus, we studied whether the hepatic adenovirus-mediated transfer of human aquaporin-1 gene (haqp1) can improve the cholestasis induced by LPS. Adenoviral vector encoding hAQP1 (AdhAQP1) or control vector was administered to rats by retrograde intrabiliary infusion. Hepatocyte canalicular hAQP1 expression was assessed by liver immunostaining and immunoblotting in purified plasma membranes. LPS reduced bile flow and biliary bile acid excretion by 30% and 45%, respectively. AdhAQP1-treatment normalized both bile flow and biliary bile acid excretion in LPS-induced cholestasis. Moreover, markedly elevated serum bile acid levels in cholestatic rats, were also normalized with the AdhAQP1 hepatic transduction. Bile flow and serum or biliary bile acids in normal rats were not significantly altered by AdhAQP1. AdhAQP1 delivery unaffected the downregulated protein expression of canalicular bile salt export pump (BSEP/ABCB11) in cholestasis, but improved its transport activity restoring reduced canalicular cholesterol content. Our data suggest that the adenovirus-mediated hepatocyte hAQP1 expression improves LPS-induced cholestasis in rats by stimulating the BSEP/ABCB11-mediated biliary bile acid excretion; a finding that might contribute to the understanding and treatment of sepsis-associated cholestatic diseases.
ÍtemAcceso Abierto
Transgredir con la mirada y la escucha : análisis de la presentación de la mujer en la película "La niña santa"
(Facultad de Ciencia Política y Relaciones Internacionales, 2024-06-06) Capisano, Catalina; Pelliza, Cecilia Macarena
El presente trabajo propone realizar un análisis crítico de la película La niña santa (2004), con el objetivo de problematizar la presentación de la mujer e identificar transformaciones en relación a las formas históricas y hegemónicas de representación. La perspectiva de análisis a utilizar serán los desarrollos de teoría de cine de Gilles Deleuze, donde se lo piensa como un dispositivo que genera imágenes, que participa activamente en la configuración de la imagen del pensamiento, y que a su vez es un arte industrial y de masas.