Aprindin
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(IUPAC) ime | |||
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{3-[2,3-dihidro-1H-inden-2-il(fenil)amino]propil}dietilamin | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
Identifikatori | |||
CAS broj | 37640-71-4 | ||
ATC kod | C01BB04 | ||
PubChem[1][2] | 2218 | ||
DrugBank | DB01429 | ||
ChemSpider[3] | 2132 | ||
UNII | 5Y48085P9Q ![]() | ||
KEGG[4] | D02969 ![]() | ||
ChEMBL[5] | CHEMBL1213033 ![]() | ||
Hemijski podaci | |||
Formula | C22H30N2 | ||
Mol. masa | 322,487 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Aprindin je antiaritmički agens klase 1b.[6]
U jednoj studiji, on je odložio atrijalnu fibirlaciji duže od digoksina.[7]
Aprindin je efektivan pri oralnoj administraciji.[8]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Sato R, Hisatome I, Tanaka Y, et al. (September 1991). „Aprindine blocks the sodium current in guinea-pig ventricular myocytes”. Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. PMID 1660104.
- ↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). „Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation”. Circ. J. 66 (6): 553–6. DOI:10.1253/circj.66.553. PMID 12074271. Arhivirano iz originala na datum 2013-10-17. Pristupljeno 2014-04-05.
- ↑ Reid PR, Greene HL, Varghese PJ (December 1977). „Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome”. Br Heart J 39 (12): 1353–60. DOI:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.