Kapecitabin
Изглед
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Klinički podaci | |
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Drugs.com | Monografija |
Način primene | Oralno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 45-60 minuta |
Izlučivanje | Renalno 95.5% |
Identifikatori | |
CAS broj | 154361-50-9 ![]() |
ATC kod | L01BC06 (WHO) |
PubChem | CID 60953 |
DrugBank | DB01101 ![]() |
ChemSpider | 54916 ![]() |
KEGG | C12650 ![]() |
ChEBI | CHEBI:31348 ![]() |
ChEMBL | CHEMBL1773 ![]() |
Hemijski podaci | |
Formula | C15H22FN3O6 |
Molarna masa | 359,350 |
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Fizički podaci | |
Tačka topljenja | 110—121 °C (230—250 °F) |
Kapecitabin je organsko jedinjenje, koje sadrži 15 atoma ugljenika i ima molekulsku masu od 359,350 Da.[1][2][3][4][5][6][7][8]
Osobine
[уреди | уреди извор]Osobina | Vrednost |
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Broj akceptora vodonika | 7 |
Broj donora vodonika | 3 |
Broj rotacionih veza | 7 |
Particioni koeficijent[9] (ALogP) | 0,8 |
Rastvorljivost[10] (logS, log(mol/L)) | -3,8 |
Polarna površina[11] (PSA, Å2) | 120,7 |
Reference
[уреди | уреди извор]- ^ Walko, C. M.; Lindley, C. (јануар 2005). „Capecitabine: A review”. Clinical Therapeutics. 27 (1): 23—44. PMID 15763604. doi:10.1016/j.clinthera.2005.01.005.
- ^ Wagstaff AJ; Ibbotson, T.; Goa, K. L. (2003). „Capecitabine: A review of its pharmacology and therapeutic efficacy in the management of advanced breast cancer”. Drugs. 63 (2): 217—36. PMID 12515569. doi:10.2165/00003495-200363020-00009.
- ^ Koukourakis, G. V.; Kouloulias, V.; Koukourakis, M. J.; Zacharias, G. A.; Zabatis, H.; Kouvaris, J. (2008-08-27). „Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: A review”. Molecules (Basel, Switzerland). 13 (8): 1897—922. PMC 6245068
. PMID 18794792. doi:10.3390/molecules13081897
.
- ^ Twelves, C. (2001). „Vision of the future: Capecitabine”. The Oncologist. 6 Suppl 4: 35—39. PMID 11585973. S2CID 25077953. doi:10.1634/theoncologist.6-suppl_4-35.
- ^ Milano, G.; Ferrero, J. M.; François, E. (2004-08-16). „Comparative pharmacology of oral fluoropyrimidines: A focus on pharmacokinetics, pharmacodynamics and pharmacomodulation”. British Journal of Cancer. 91 (4): 613—7. PMC 2364788
. PMID 15280932. doi:10.1038/sj.bjc.6601973.
- ^ De Bono, J. S.; Twelves, C. J. (2001). „The oral fluorinated pyrimidines”. Investigational New Drugs. 19 (1): 41—59. PMID 11291832. S2CID 5691855. doi:10.1023/a:1006404701008.
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
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