- Obesity, Internal Medicine (General Medicine), Medical Education (in Education), Pathophysiology, Novel risk factors for CVD, Endothelial dysfunction, and 18 moreArterial hypertension, Colorectal cancer, Blood Pressure, Lipid metabolism, Ultrasonography, Serum Creatinine, Subclinical Atherosclerosis, Carotid Plaques, Carotid-Intima Media Thickness, Primary Antiphospholipid Syndrome, Serum Uric Acid, Intima-Media Thickness, Antiphospholipid antibodies, Renal Function, Blood Urea Nitrogen, Elderly Hypertensive Patients, Cardiology, and Clinical Trialedit
- Corina Serban, MD, PhD is Assistant Professor at Pathophysiology Department University of Medicine and Pharmacy “Vict... moreCorina Serban, MD, PhD is Assistant Professor at Pathophysiology Department University of Medicine and Pharmacy “Victor Babes” Timisoara. Dr. Serban completed her undergraduate degree at National College Mircea Cel Batran, Rm.Valcea, Romania. She received her M.D. from University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania. She holds a PhD in Internal Medicine from University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania. Her principal research interests include mechanism involved in atherosclerosis, mechanisms of vascular endothelial dysfunction, mechanisms of insulin resistance and mechanisms of inflammation in hypertensive patients with associated atherogenic dyslipidemia, metabolic syndrome or type 2 diabetes.
Her research focuses particularly on biochemical parameters like: serum uric acid, lipoprotein(a), apolipoprotein A-I, apolipoprotein B, fibrinogen, high sensitivity C reactive protein and ultrasound parameters like carotid intima-media thickness (CIMT) and flow-mediated vasodilatation (FMD). Dr. Serban’ clinical interests include preventive cardiology, which include lipid, hypertension, nutrition and risk reduction.edit
Sun protection has become an important aspect of every day life. As more UV radiations pass every day through the ozone layer, people are being exposed to severe risks. Pigmentation, sun burns, early aging are some of the side-affects... more
Sun protection has become an important aspect of every day life. As more UV radiations pass every day through the ozone layer, people are being exposed to severe risks. Pigmentation, sun burns, early aging are some of the side-affects associated with sun exposure. ...
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Page 1. 10 Late Ventricular Potentials in Cardiac and Extracardiac Diseases Ioana Mozoş, Corina Şerban and Rodica Mihăescu “Victor Babeş” University of Medicine and Pharmacy, Timisoara Romania 1. Introduction Late ventricular ...
Circulating lipoprotein (a) (Lp(a)) is a recognized risk factor for cardiovascular disease (CVD). Tibolone, a synthetic steroid, may lower Lp(a) levels; however, evidence of the effects of tibolone on Lp(a) still remain to be defined.... more
Circulating lipoprotein (a) (Lp(a)) is a recognized risk factor for cardiovascular disease (CVD). Tibolone, a synthetic steroid, may lower Lp(a) levels; however, evidence of the effects of tibolone on Lp(a) still remain to be defined. Therefore, we investigated the effects of tibolone treatment on circulating Lp(a) levels in postmenopausal women. The search included PUBMED, Web of Science, Scopus, and Google Scholar (up to January 31st, 2015) to identify controlled clinical studies investigating the effects of oral tibolone treatment on Lp(a) levels in postmenopausal women. Random-effects meta-regression was performed using unrestricted maximum likelihood method for the association between calculated weighted mean difference (WMD) and potential moderators. Meta-analysis of data from 12 trials (16 treatment arms) suggested a significant reduction of Lp(a) levels following tibolone treatment (WMD: -25.28%, 95% confidence interval [CI]: -36.50, -14.06; p < 0.001). This result was ro...
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Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence as to the significance of this effect is unclear. We assessed the impact of statin therapy on plasma CoQ10 concentrations through the meta-analysis of... more
Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence as to the significance of this effect is unclear. We assessed the impact of statin therapy on plasma CoQ10 concentrations through the meta-analysis of available RCTs. The literature search included selected databases up to April 30, 2015. The meta-analysis was performed using either a fixed-effects or random-effect model according to I(2) statistic. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI). The data from 8 placebo-controlled treatment arms suggested a significant reduction in plasma CoQ10 concentrations following treatment with statins (WMD: -0.44μmol/L, 95%CI: -0.52, -0.37, p<0.001). The pooled effect size was robust and remained significant in the leave-one-out sensitivity analysis. Subgroup analysis suggested that the impact of statins on plasma CoQ10 concentrations is significant for all 4 types of statins studied i.e. atorvastatin (WMD: ...
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Research Interests:
Background & aims Many experimental and clinical trials suggested that flaxseed might be a potent antihypertensive, but the evidences concerning the effects of flaxseed supplements on blood pressure (BP) has not been fully conclusive. We... more
Background & aims
Many experimental and clinical trials suggested that flaxseed might be a potent antihypertensive, but the evidences concerning the effects of flaxseed supplements on blood pressure (BP) has not been fully conclusive. We aimed to assess the impact of the effects of flaxseed supplements on blood pressure through systematic review of literature and meta-analysis of available randomized controlled trials (RCTs).
Methods
The literature search included PUBMED, Cochrane Library, Scopus, and EMBASE up to February 2015 to identify RCTs investigating the effect of flaxseed supplements on plasma blood pressure. Effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI).
Results
15 trials (comprising 19 treatment arms) with 1302 participants were included in this meta-analysis. Random-effects meta-analysis suggested significant reductions in both systolic BP (SBP) (WMD: −2.85 mmHg, 95%CI: −5.37 to −0.33, p = 0.027) and diastolic BP (DBP) (WMD: −2.39 mmHg, 95%CI: −3.78 to −0.99, p = 0.001) following supplementation with flaxseed products. When the studies were stratified according to their duration, there was a greater effect on both SBP and DBP in the subset of trials with ≥12 weeks of duration (WMD: −3.10 mmHg, 95%CI: −6.46 to 0.27, p = 0.072 and −2.62 mmHg, 95%CI: −4.39 to −0.86, p = 0.003, respectively) vs the subset lasting <12 weeks (WMD: −1.60 mmHg, 95%CI: −5.44 to 2.24, p = 0.413, and −1.74 mmHg, 95%CI: −4.41 to 0.93, p = 0.202, respectively). Another subgroup analysis was performed to assess the impact of flaxseed supplement type on BP. Reduction of SBP was significant with flaxseed powder (WMD: −1.81 mmHg, 95% CI: −2.03 to −1.59, p < 0.001) but not oil (WMD: −4.62 mmHg, 95%CI: −11.86 to 2.62, p = 0.211) and lignan extract (WMD: 0.28 mmHg, 95% CI: −3.49 to 4.04, p = 0.885). However, DBP was significantly reduced with powder and oil preparations (WMD: −1.28 mmHg, 95% CI: −2.44 to −0.11, p = 0.031, and −4.10 mmHg, 95%CI: −6.81 to −1.39, p = 0.003, respectively), but not with lignan extract (WMD: −1.78 mmHg, 95% CI: −4.28 to 0.72, p = 0.162).
Conclusions
This meta-analysis of RCTs showed significant reductions in both SBP and DBP following supplementation with various flaxseed products.
Many experimental and clinical trials suggested that flaxseed might be a potent antihypertensive, but the evidences concerning the effects of flaxseed supplements on blood pressure (BP) has not been fully conclusive. We aimed to assess the impact of the effects of flaxseed supplements on blood pressure through systematic review of literature and meta-analysis of available randomized controlled trials (RCTs).
Methods
The literature search included PUBMED, Cochrane Library, Scopus, and EMBASE up to February 2015 to identify RCTs investigating the effect of flaxseed supplements on plasma blood pressure. Effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI).
Results
15 trials (comprising 19 treatment arms) with 1302 participants were included in this meta-analysis. Random-effects meta-analysis suggested significant reductions in both systolic BP (SBP) (WMD: −2.85 mmHg, 95%CI: −5.37 to −0.33, p = 0.027) and diastolic BP (DBP) (WMD: −2.39 mmHg, 95%CI: −3.78 to −0.99, p = 0.001) following supplementation with flaxseed products. When the studies were stratified according to their duration, there was a greater effect on both SBP and DBP in the subset of trials with ≥12 weeks of duration (WMD: −3.10 mmHg, 95%CI: −6.46 to 0.27, p = 0.072 and −2.62 mmHg, 95%CI: −4.39 to −0.86, p = 0.003, respectively) vs the subset lasting <12 weeks (WMD: −1.60 mmHg, 95%CI: −5.44 to 2.24, p = 0.413, and −1.74 mmHg, 95%CI: −4.41 to 0.93, p = 0.202, respectively). Another subgroup analysis was performed to assess the impact of flaxseed supplement type on BP. Reduction of SBP was significant with flaxseed powder (WMD: −1.81 mmHg, 95% CI: −2.03 to −1.59, p < 0.001) but not oil (WMD: −4.62 mmHg, 95%CI: −11.86 to 2.62, p = 0.211) and lignan extract (WMD: 0.28 mmHg, 95% CI: −3.49 to 4.04, p = 0.885). However, DBP was significantly reduced with powder and oil preparations (WMD: −1.28 mmHg, 95% CI: −2.44 to −0.11, p = 0.031, and −4.10 mmHg, 95%CI: −6.81 to −1.39, p = 0.003, respectively), but not with lignan extract (WMD: −1.78 mmHg, 95% CI: −4.28 to 0.72, p = 0.162).
Conclusions
This meta-analysis of RCTs showed significant reductions in both SBP and DBP following supplementation with various flaxseed products.
Research Interests:
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Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent... more
Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin associated muscle symptoms (SAMS), and avoided the use of the term 'statin intolerance'. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10-15% of patients. In clinical practice, statin intolerance limits effective treatment of patients at risk of, or with, cardiovascular disease. Knowledge of the most common adverse effects of statin therapy that might cause statin intolerance and the clear definition of this phenomenon is crucial to effectively treat patients with lipid disorders. Therefore, the aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.
Research Interests:
Research Interests:
Lp(a) is capable of deleteriously altering the balance between the procoagulant and anticoagulant, proinflammatory and anti-inflammatory, and vasorelaxing and vasoconstricting properties of the endothelium. The purpose of this study was... more
Lp(a) is capable of deleteriously altering the balance between the procoagulant and anticoagulant, proinflammatory and anti-inflammatory, and vasorelaxing and vasoconstricting properties of the endothelium. The purpose of this study was to investigate the serum concentration of Lp(a) and the main parameters of lipid profile in three groups of subjects: a control group that included 16 healthy subjects, 20 patients with arterial hypertension and dyslipidemia and 20 patients with arterial hypertension without dyslipidemia. Using B-mode ultrasonography, we evaluated carotid intima-media thickness (IMT) and flow mediated vasodilation (FMD) on brachial artery. We found significant higher Lp(a) concentrations in hypertensive patients with dislipidemia (70 +/- 55.95 mg/dL, p < 0.001) and in hypertensive patients without dislipidemia (69 +/- 52.33 mg/dL, p < 0.001), comparative with the control group (19 +/- 14.64 mg/dL). In hypertensive patients with dislipidemia we found a strong ne...
Research Interests: Humans, Hypertension, Female, Male, Vascular endothelium, and 13 moreRisk factors, Triglycerides, Middle Aged, Prognosis, Biological markers, Risk Factors, Sensitivity and Specificity, Vasodilation, Predictive value of tests, Lipoprotein a, Case Control Studies, Brachial artery, and Carotid Arteries
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The standard 12-lead ECG (electrocardiogram) continues to be the most frequently recorded noninvasive test in medicine. A prolonged ECG QT interval and Tpeak-Tend (Tpe) interval are predictors of ventricular arrhythmia and sudden cardiac... more
The standard 12-lead ECG (electrocardiogram) continues to be the most frequently recorded noninvasive test in medicine. A prolonged ECG QT interval and Tpeak-Tend (Tpe) interval are predictors of ventricular arrhythmia and sudden cardiac death. The aim of this study is to analyze the relation between QT interval and T-wave variables in hypertensive patients, with and without left ventricular hypertrophy (LVH). Fifty-nine consecutive patients with grade 2 essential hypertension were included in the study. They underwent standard 12-lead ECG, and QT intervals: QTmax (the maximal duration of the QT interval in the 12 ECG leads), QTc (heart rate corrected QTmax), QTm (mean QT interval), QTII (the QT interval in lead DII), QTcII (heart rate corrected QTII), and QTd (QT dispersion); and T-wave variables: T0e (T wave duration), T0em (mean T0e), Tpe, Tpem (mean Tpem), Ta (T wave amplitude), and Tam (mean Ta) were manually assessed. LVH was diagnosed using both echocardiography and the ECG criteria. QTc was prolonged in 41 patients (69%). Multiple regression analysis revealed a significant association between QT intervals and T-wave variables: QTmax and Tpe (P = 0.015), QTd and Tpe (P = 0.022) and Ta (P = 0.004), and Tpe with QTd and T0e (P &amp;amp;amp;amp;lt; 0.05). A moderate but significant correlation was found between Tpe and QTmax, Tpe and QTII, and Ta and QTd. A prolonged QTc was more prevalent in hypertensive patients with LVH (85%), compared to hypertensive patients without LVH (50%). QTm, QTd, QTII, Tpe, Tpem were significantly elevated (P &amp;amp;amp;amp;lt; 0.05) in patients with LVH. Hypertension is associated with an increased prevalence of prolonged QT intervals. QT intervals and T-wave variables are closely connected in hypertensive patients. QTm, T0em, Tpem, and Tam, do not provide significant additional information compared to QTmax, T0e, Tpe, and Ta. Left ventricular hypertrophy is associated with prolonged QT interval and Tpeak-Tend interval in hypertensive patients.
Summary Background & aims The impact of Spirulina supplementation on plasma lipid concentrations has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of Spirulina supplementation on plasma... more
Summary
Background & aims
The impact of Spirulina supplementation on plasma lipid concentrations has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of Spirulina supplementation on plasma lipid concentrations.
Methods
We searched PubMed and Scopus (up to July 03, 2015) to identify randomized controlled trials (RCTs) that investigate the effect Spirulina supplementation on plasma lipid concentrations. Meta-analysis and meta-regression were performed using random-effects models.
Results
Random-effect meta-analysis of data from 7 RCTs showed a significant effect of supplementation with spirulina in reducing plasma concentrations of total cholesterol (WMD: −46.76 mg/dL, 95% CI: −67.31 to −26.22, p < 0.001), LDL-C (WMD: −41.32 mg/dL, 95% CI: −60.62 to −22.03, p < 0.001) and triglycerides (WMD: −44.23 mg/dL, 95% CI: −50.22 to −38.24, p < 0.001), and elevating those of HDL-C (WMD: 6.06 mg/dL, 95% CI: 2.37–9.76, p = 0.001).
The impact of spirulina on plasma concentrations of total cholesterol (slope: −1.32; 95% CI: −8.58 to 5.93; p = 0.720), LDL-C (slope: −1.01; 95% CI: −8.03 to 6.02; p = 0.778), triglycerides (slope: −1.39; 95% CI: −4.26 to 1.48; p = 0.342) and HDL-C (slope: 1.79, 95% CI: −0.48 to 4.05; p = 0.122) was independent of administered dose. Regarding duration of supplementation with Spirulina, significant associations were found with changes in plasma concentrations of total cholesterol (slope: −1.77; 95% CI: −3.48 to −0.07; p = 0.042), LDL-C (slope: −1.73; 95% CI: −3.40 to −0.06; p = 0.042) HDL-C (slope: 0.91; 95% CI: 0.68–1.14; p < 0.001) and triglycerides (slope: −1.39; 95% CI: −2.28 to −0.50; p = 0.002).
Conclusions
This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C.
Keywords
Spirulina platensis; Lipid; LDL-cholesterol; HDL-cholesterol; Meta-analysis; Systematic review
Background & aims
The impact of Spirulina supplementation on plasma lipid concentrations has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of Spirulina supplementation on plasma lipid concentrations.
Methods
We searched PubMed and Scopus (up to July 03, 2015) to identify randomized controlled trials (RCTs) that investigate the effect Spirulina supplementation on plasma lipid concentrations. Meta-analysis and meta-regression were performed using random-effects models.
Results
Random-effect meta-analysis of data from 7 RCTs showed a significant effect of supplementation with spirulina in reducing plasma concentrations of total cholesterol (WMD: −46.76 mg/dL, 95% CI: −67.31 to −26.22, p < 0.001), LDL-C (WMD: −41.32 mg/dL, 95% CI: −60.62 to −22.03, p < 0.001) and triglycerides (WMD: −44.23 mg/dL, 95% CI: −50.22 to −38.24, p < 0.001), and elevating those of HDL-C (WMD: 6.06 mg/dL, 95% CI: 2.37–9.76, p = 0.001).
The impact of spirulina on plasma concentrations of total cholesterol (slope: −1.32; 95% CI: −8.58 to 5.93; p = 0.720), LDL-C (slope: −1.01; 95% CI: −8.03 to 6.02; p = 0.778), triglycerides (slope: −1.39; 95% CI: −4.26 to 1.48; p = 0.342) and HDL-C (slope: 1.79, 95% CI: −0.48 to 4.05; p = 0.122) was independent of administered dose. Regarding duration of supplementation with Spirulina, significant associations were found with changes in plasma concentrations of total cholesterol (slope: −1.77; 95% CI: −3.48 to −0.07; p = 0.042), LDL-C (slope: −1.73; 95% CI: −3.40 to −0.06; p = 0.042) HDL-C (slope: 0.91; 95% CI: 0.68–1.14; p < 0.001) and triglycerides (slope: −1.39; 95% CI: −2.28 to −0.50; p = 0.002).
Conclusions
This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C.
Keywords
Spirulina platensis; Lipid; LDL-cholesterol; HDL-cholesterol; Meta-analysis; Systematic review
Research Interests:
BACKGROUND: Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been... more
BACKGROUND:
Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been inconclusive. Consequently, we performed a systematic review and meta-analysis to investigate the impact of statin therapy on plaque volume and its composition using VH-IVUS.
METHODS:
The search included PubMed, Cochrane Library, Scopus and Embase (through 30 November 2014) to identify prospective studies investigating the effects of statin therapy on plaque volume and its composition using VH-IVUS.
RESULTS:
We identified nine studies with 16 statin treatment arms and 830 participants. There was a significant effect of statin therapy in reducing plaque volume (standardized mean difference (SMD): -0.137, 95 % confidence interval (CI): -0.255, -0.019; P = 0.023), external elastic membrane volume (SMD: -0.097, 95 % CI: -0.183, -0.011; P = 0.027) but not lumen volume (SMD: -0.025, 95 % CI: -0.110, +0.061; P = 0.574). There was a significant reduction in fibrous plaque volume (SMD: -0.129, 95 % CI: -0.255, -0.003; P = 0.045) and an increase of dense calcium volume (SMD: +0.229, 95 % CI: +0.008, +0.450; P = 0.043), while changes in fibro-fatty (SMD: -0.247, 95 % CI: -0.592, +0.098; P = 0.16) and necrotic core (SMD: +0.011, 95 % CI: -0.144, +0.165; P = 0.892) tissue volumes were not statistically significant.
CONCLUSIONS:
This meta-analysis indicates a significant effect of statin therapy on plaque and external elastic membrane volumes and fibrous and dense calcium volumes. There was no effect on lumen volume, fibro-fatty and necrotic tissue volumes.
Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been inconclusive. Consequently, we performed a systematic review and meta-analysis to investigate the impact of statin therapy on plaque volume and its composition using VH-IVUS.
METHODS:
The search included PubMed, Cochrane Library, Scopus and Embase (through 30 November 2014) to identify prospective studies investigating the effects of statin therapy on plaque volume and its composition using VH-IVUS.
RESULTS:
We identified nine studies with 16 statin treatment arms and 830 participants. There was a significant effect of statin therapy in reducing plaque volume (standardized mean difference (SMD): -0.137, 95 % confidence interval (CI): -0.255, -0.019; P = 0.023), external elastic membrane volume (SMD: -0.097, 95 % CI: -0.183, -0.011; P = 0.027) but not lumen volume (SMD: -0.025, 95 % CI: -0.110, +0.061; P = 0.574). There was a significant reduction in fibrous plaque volume (SMD: -0.129, 95 % CI: -0.255, -0.003; P = 0.045) and an increase of dense calcium volume (SMD: +0.229, 95 % CI: +0.008, +0.450; P = 0.043), while changes in fibro-fatty (SMD: -0.247, 95 % CI: -0.592, +0.098; P = 0.16) and necrotic core (SMD: +0.011, 95 % CI: -0.144, +0.165; P = 0.892) tissue volumes were not statistically significant.
CONCLUSIONS:
This meta-analysis indicates a significant effect of statin therapy on plaque and external elastic membrane volumes and fibrous and dense calcium volumes. There was no effect on lumen volume, fibro-fatty and necrotic tissue volumes.
Research Interests:
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Introduction: Target organ damage (TOD) can be evaluated in outpatient clinics and offers valuable information about patient's cardiovascular risk. Clinical evidence supported the possibility that serum uric acid (SUA) may lead to... more
Introduction: Target organ damage (TOD) can be evaluated in outpatient clinics and offers valuable information about patient's cardiovascular risk. Clinical evidence supported the possibility that serum uric acid (SUA) may lead to hypertension. Carotid intima–media thickness (carotid IMT) measured noninvasively by ultrasonography is now widely used as a surrogate marker for atherosclerosis.
Goal: to investigate the association of SUA with markers of target organ damage like carotid IMT and microalbuminuria in hypertensive patients and to observe the distribution of SUA levels considering one, two, three or more TOD.
Material and methods: The study was conducted on a sample of 182 hypertensive patients. They underwent extensive clinical, laboratory, and ultrasonographic investigations searching for cardiac, vascular and renal TOD. The patients were divided into four groups as follows: no TOD (Group I, n=24); 1 TOD (Group II, n=50); 2 TOD (Group III, n=40); and ≥ 3 TOD (Group IV, n=48). Carotid IMT was performed using high-resolution B-mode ultrasonography according to Mannheim Consensus.
Results: Uric acid was directly associated with the number of affected organs. Uric acid was significantly higher in the group IV versus group III (p<0.001), in the group III versus group II, p<0.001) and in the group II versus group I (p<0.001). Carotid IMT was also directly associated with the number of affected
organs. The value of carotid IMT was significantly higher in the group IV versus group III (p<0.001), in the group III versus group II, (p<0.001) and in the group II versus group I (p<0.001). We obtained a strong significantly correlation between serum uric acid levels and carotid IMT (r=0.86, p<0.001) and between carotid IMT and microalbuminuria (r=0.74, p<0.001).
Conclusion: The study showed that increased values of SUA and carotid IMT are associated with the number of TOD, thus SUA and carotid IMT may be considered indicators for evaluating TOD.
Goal: to investigate the association of SUA with markers of target organ damage like carotid IMT and microalbuminuria in hypertensive patients and to observe the distribution of SUA levels considering one, two, three or more TOD.
Material and methods: The study was conducted on a sample of 182 hypertensive patients. They underwent extensive clinical, laboratory, and ultrasonographic investigations searching for cardiac, vascular and renal TOD. The patients were divided into four groups as follows: no TOD (Group I, n=24); 1 TOD (Group II, n=50); 2 TOD (Group III, n=40); and ≥ 3 TOD (Group IV, n=48). Carotid IMT was performed using high-resolution B-mode ultrasonography according to Mannheim Consensus.
Results: Uric acid was directly associated with the number of affected organs. Uric acid was significantly higher in the group IV versus group III (p<0.001), in the group III versus group II, p<0.001) and in the group II versus group I (p<0.001). Carotid IMT was also directly associated with the number of affected
organs. The value of carotid IMT was significantly higher in the group IV versus group III (p<0.001), in the group III versus group II, (p<0.001) and in the group II versus group I (p<0.001). We obtained a strong significantly correlation between serum uric acid levels and carotid IMT (r=0.86, p<0.001) and between carotid IMT and microalbuminuria (r=0.74, p<0.001).
Conclusion: The study showed that increased values of SUA and carotid IMT are associated with the number of TOD, thus SUA and carotid IMT may be considered indicators for evaluating TOD.
Research Interests:
Metabolic syndrome (MS) predisposes to cardiovascular disease. Endothelial dysfunction is thought to be an important factor in the pathogenesis of atherosclerosis. The aim of this study was to compare lipid metabolism parameters and... more
Metabolic syndrome (MS) predisposes to cardiovascular disease. Endothelial dysfunction is thought to be an important factor in the pathogenesis of atherosclerosis. The aim of this study was to compare lipid metabolism parameters and endothelial function assessed by ultrasonography of the brachial artery in hypertensive patients with and without metabolic syndrome. Our study comprised a group of 24 patients with arterial hypertension without atherogenic dyslipidemia (HTN-DYS) (mean age ± S.D.: 54 ± 4.80 years) and a group made of 48 patients with arterial hypertension and metabolic syndrome (HTN+MS) (aged: 57 ± 3.67 years). Metabolic syndrome was diagnosed considering ATP III criteria. Flow-mediated endothelium-dependent dilatation (FMD) in the brachial artery during reactive hyperemia was examined by high-resolution ultrasound technique. We observed in HTN+MS patients significant higher levels of TC (p<0.001), LDL-C (p<0.001) and TG (p<0.001) compared to HTN-DYS patients. The values of HDL-C in HTN+MS patients were significantly decreased compared to HTN-DYS patients (p<0.001). The values obtained for FMD in HTN+MS patients were significantly decreased compared to the values for FMD obtained in HTN-DYS patients (p=0.02). BMI, CA and WHR were also significant higher in hypertensive patients with MS. Endothelial dysfunction is present in patients with arterial hypertension and metabolic syndrome. Abdominal obesity and atherogenic dyslipidemia may contribute to the pathogenesis of endothelial dysfunction in these patients.
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The metabolic syndrome (MS) is a clinical concept that comprises a cluster of risk factors like arterial hypertension, obesity and high cholesterol in the same patient. The aim of this study was to investigate whether the metabolic... more
The metabolic syndrome (MS) is a clinical concept that comprises a cluster of risk factors like arterial hypertension, obesity and high cholesterol in the same patient. The aim of this study was to investigate whether the metabolic syndrome is related to the extent of vascular damage evaluated by carotid intima-media thickness. Our study comprised two groups: the
first group of 50 hypertensive patients (aged 56 ± 5.60 years) and the second group of 41 hypertensive patients with metabolic syndrome (aged 56 ± 3.62 years). MS was defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines. In all the patients we determined intima-media thickness by B-mode ultrasound technique and according to the Mannheim Consensus. We observed in patients of the second group significantly increased values for anthropometric parameters such as body mass index (p<0.001), waist circumference (p<0.001) and waist-hip ratio (p<0.001) compared to the first group. The differences between groups considering the levels of total cholesterol (p<0.001), triglycerides (p<0.001), LDL-cholesterol (p<0.001), and HDL-cholesterol (p<0.001) were
also statistically significant. The patients from the second group had significantly increased carotid IMT values compared to the patients from the first group (1.27±0.03 mm vs. 1.00±0.03 mm, p<0.001). The study revealed that metabolic syndrome is associated with
structurally-functional changes of arterial vessels (increased IMT).
first group of 50 hypertensive patients (aged 56 ± 5.60 years) and the second group of 41 hypertensive patients with metabolic syndrome (aged 56 ± 3.62 years). MS was defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines. In all the patients we determined intima-media thickness by B-mode ultrasound technique and according to the Mannheim Consensus. We observed in patients of the second group significantly increased values for anthropometric parameters such as body mass index (p<0.001), waist circumference (p<0.001) and waist-hip ratio (p<0.001) compared to the first group. The differences between groups considering the levels of total cholesterol (p<0.001), triglycerides (p<0.001), LDL-cholesterol (p<0.001), and HDL-cholesterol (p<0.001) were
also statistically significant. The patients from the second group had significantly increased carotid IMT values compared to the patients from the first group (1.27±0.03 mm vs. 1.00±0.03 mm, p<0.001). The study revealed that metabolic syndrome is associated with
structurally-functional changes of arterial vessels (increased IMT).
Research Interests:
Background: Several novel criteria can improve detection of subclinical atherosclerosis. In particular, the clinical interest has focused on lipoprotein(a), a modified LDL particle which presents a structurally homologue protein to... more
Background: Several novel criteria can improve detection of subclinical atherosclerosis. In particular, the clinical interest has focused on lipoprotein(a), a modified LDL particle which presents a structurally homologue protein to plasminogen.
Aim: The aim of our work was to evaluate the levels of lipoprotein(a), in hypertensive patients with or without atherogenic dyslipidemia comparative with a control group and to estimate the relationship of Lp(a) with other biological and functional parameters.
Methods: The study included 40 hypertensive patients with atherogenic dyslipidemia (HTN+DYS), 43 hypertensive patients without atherogenic dyslipidemia (HTN-DYS) and 35 control subjects, aged and sex matched. The hypertensive patients were not receiving pharmacological therapy and had no clinical signs of associated pathologies or organ damage. We determined in all groups the levels of Lp(a), apolipoprotein A-I and apolipoproteinB and fibrinogen. Lipoprotein(a) was measured by enzyme immuno assay (ELISA) test. Using B-mode ultrasonography we determined carotid intima-media thickness (IMT) and flow mediated vasodilatation (FMD) in all patients.
Results: Lp(a) was significantly higher in HTN+DYS group than in HTN-DYS group and than in control group (77.18 ± 48.51 mg/dL versus 58.14 ± 47.31 mg/dL versus 22.64 ±11.86 mg/dL versus , p<0.001). A significant correlation was found between Lp(a) and IMT (r = 0.64, p < 0.001), between Lp(a) and fibrinogen (r = 0.78, p < 0.001), and between Lp(a) and brachial FMD (r = -0.29, p < 0.001). Lp(a) levels were not correlated with total cholesterol, LDL-cholesterol, HDL-cholesterol, apolipoproteins A-I or B or apoA-I/apoB.
Study Limitations: Potential limitations of our study are the relative small number of patients and controls and missing apo(a) phenotype.
Conclusion: Lp(a) levels are related to early structural changes of the carotid arteries as shown by ultrasound measurements of IMT and to early functional changes evaluated by brachial FMD and can be considered an emerging risk factor for premature atherosclerosis.
Aim: The aim of our work was to evaluate the levels of lipoprotein(a), in hypertensive patients with or without atherogenic dyslipidemia comparative with a control group and to estimate the relationship of Lp(a) with other biological and functional parameters.
Methods: The study included 40 hypertensive patients with atherogenic dyslipidemia (HTN+DYS), 43 hypertensive patients without atherogenic dyslipidemia (HTN-DYS) and 35 control subjects, aged and sex matched. The hypertensive patients were not receiving pharmacological therapy and had no clinical signs of associated pathologies or organ damage. We determined in all groups the levels of Lp(a), apolipoprotein A-I and apolipoproteinB and fibrinogen. Lipoprotein(a) was measured by enzyme immuno assay (ELISA) test. Using B-mode ultrasonography we determined carotid intima-media thickness (IMT) and flow mediated vasodilatation (FMD) in all patients.
Results: Lp(a) was significantly higher in HTN+DYS group than in HTN-DYS group and than in control group (77.18 ± 48.51 mg/dL versus 58.14 ± 47.31 mg/dL versus 22.64 ±11.86 mg/dL versus , p<0.001). A significant correlation was found between Lp(a) and IMT (r = 0.64, p < 0.001), between Lp(a) and fibrinogen (r = 0.78, p < 0.001), and between Lp(a) and brachial FMD (r = -0.29, p < 0.001). Lp(a) levels were not correlated with total cholesterol, LDL-cholesterol, HDL-cholesterol, apolipoproteins A-I or B or apoA-I/apoB.
Study Limitations: Potential limitations of our study are the relative small number of patients and controls and missing apo(a) phenotype.
Conclusion: Lp(a) levels are related to early structural changes of the carotid arteries as shown by ultrasound measurements of IMT and to early functional changes evaluated by brachial FMD and can be considered an emerging risk factor for premature atherosclerosis.
Research Interests:
Recent studies have indicated that lipoprotein(a) [Lp(a)] and fibrinogen are novel risk factors for systemic atherosclerosis. The main objective of this study was to evaluate the level of Lp(a) and fibrinogen in patients with essential... more
Recent studies have indicated that lipoprotein(a) [Lp(a)] and fibrinogen are novel risk factors for systemic atherosclerosis. The main objective of this study was to evaluate the level of Lp(a) and fibrinogen in patients with essential hypertension. The study comprised 20 patients with arterial hypertension and dyslipidemia, 20 patients with arterial hypertension without dyslipidemia and 16 age- and sex-matched control subjects. In all patients, the plasma total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, non-HDL-cholesterol, TC/HDL-cholesterol ratio, LDL-cholesterol/HDL-cholesterol ratio, Lp(a) and fibrinogen levels were evaluated. Using B-mode ultrasonography, we evaluated carotid intima-media thickness (IMT). We found significant higher Lp(a) levels in hypertensive patients with or without comparative with the control group. The most elevated concentrations of fibrinogen were found in hypertensive group with dyslipidemia comparative with hypertensive group without dyslipidemia and with the control group. We found a strong positive correlation between Lp(a) and IMT (p < 0.001), and a moderate positive correlation between Lp(a) and fibrinogen (p < 0.001) and between fibrinogen and IMT (p < 0.001). The measurement of IMT could represent a simple and noninvasive method to monitor hypertensive subjects, with higher levels of Lp(a) and fibrinogen, indifferently of the status of traditionally dyslipidemic risk factors.
Research Interests:
Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. The purpose of this study was to evaluate the correlation between plasmatic level of apoB and standard... more
Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. The purpose of this study was to evaluate the correlation between plasmatic level of apoB and standard lipid profile parameters in type 2 hypertensive patients with or without dyslipidemia. Three groups of subjects were included in the study: a control group that included 35 healthy subjects (40%
males, 60% females, mean age 56 ±5.07 years), 43 patients with arterial hypertension without dyslipidemia (44% males, 56% females, mean age 55±4.79 years) and 40 patients with arterial hypertension with dyslipidemia (37.5% males, 62.5% females, mean age 56±3.72 years). Blood pressure, fasting glucose, lipid profile parameters and apoB were measured in all subjects. ApoB has significantly higher values in hypertensive patients with
dyslipidemia (1.51 ± 0.21 g/L) comparative with hypertensive patients without dislipidemia (0.86 ± 0.18 g/L, p<0.001), and with the control group (0.85 ± 0.13 g/L, p<0.001). It was obtained a strong and significant correlation between apoB and TC (R2 = 0.78, p<0.001), between apoB and LDL-C (r = 0.78, p<0.001), a moderate but significant correlation between apoB and tryglicerides (r = 0.78, p<0.001), and a negative, moderate but significant correlation between apoB and HDL-C (r = -0.47, p<0.001). These results indicated the fact that apoB could be considered a quantitative index of plasma atherogenity
in hypertensive patients with atherogenic dyslipidemia.
males, 60% females, mean age 56 ±5.07 years), 43 patients with arterial hypertension without dyslipidemia (44% males, 56% females, mean age 55±4.79 years) and 40 patients with arterial hypertension with dyslipidemia (37.5% males, 62.5% females, mean age 56±3.72 years). Blood pressure, fasting glucose, lipid profile parameters and apoB were measured in all subjects. ApoB has significantly higher values in hypertensive patients with
dyslipidemia (1.51 ± 0.21 g/L) comparative with hypertensive patients without dislipidemia (0.86 ± 0.18 g/L, p<0.001), and with the control group (0.85 ± 0.13 g/L, p<0.001). It was obtained a strong and significant correlation between apoB and TC (R2 = 0.78, p<0.001), between apoB and LDL-C (r = 0.78, p<0.001), a moderate but significant correlation between apoB and tryglicerides (r = 0.78, p<0.001), and a negative, moderate but significant correlation between apoB and HDL-C (r = -0.47, p<0.001). These results indicated the fact that apoB could be considered a quantitative index of plasma atherogenity
in hypertensive patients with atherogenic dyslipidemia.
Research Interests:
Hyperuricemia (HU) is associated with hypertension, vascular disease, and renal disease and is a well recognized risk factor for cardiovascular diseases. Carotid Intima-media thickness (IMT) of the carotid arteries assessed noninvasively... more
Hyperuricemia (HU) is associated with hypertension, vascular disease, and renal disease and is a well recognized risk factor for cardiovascular diseases. Carotid Intima-media thickness (IMT) of the carotid arteries assessed noninvasively by ultrasonography is now validated as a sensitive marker for atherosclerosis and it is directly associated with increased risk of cardiovascular disease and is predictive of future cardiovascular events. The aim of this study was to evaluate the role of uric acid as a risk factor for cardiovascular disease and arterial hypertension (HTA). Our study consisted of a group of 85 patients with HTA without HU (male 58%, mean age ± S.D.: 49 ± 10 years), a group of 80 patients with HTA and HU (male 52%, mean age ± S.D: 52 ± 10 years), and a control group of 80 healthy subjects (male 55%, mean age ± S.D: 50 ± 11 years) hospitalized in the IVth Medical Clinic of University of Medicine and Pharmacy “Victor Babes” Timisoara in a one year period. The patients underwent complete clinical and paraclinical investigations (systolic and diastolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides and serum uric acid). All the patients in the study groups were also examined by high resolution B-mode ultrasound to measure the IMT of the common carotid artery.
IMT values were significantly higher in the hypertensive patients groups with and without HU, compared to the control group (0.98 ± 0.28 mm, 1.41 ± 0.31 mm versus 0.56 ± 0.15 mm, respectively, p < 0.001). All patients with HU had significantly higher carotid IMT compared to the patients without HU. In this study we have shown that higher serum uric acid levels are associated with atherogenesis independently from hypertension. Early screening for hyperuricemia and lowering serum uric acid levels might be beneficial in slowing progression of IMT in hypertensive patients.
IMT values were significantly higher in the hypertensive patients groups with and without HU, compared to the control group (0.98 ± 0.28 mm, 1.41 ± 0.31 mm versus 0.56 ± 0.15 mm, respectively, p < 0.001). All patients with HU had significantly higher carotid IMT compared to the patients without HU. In this study we have shown that higher serum uric acid levels are associated with atherogenesis independently from hypertension. Early screening for hyperuricemia and lowering serum uric acid levels might be beneficial in slowing progression of IMT in hypertensive patients.
Research Interests:
Hypertension is a major cause of morbidity and mortality worldwide. The kidney is an important target of hypertension-induced organ damage. High cholesterol and triglyceride plasma levels have been demonstrated to be independent risk... more
Hypertension is a major cause of morbidity and mortality worldwide. The kidney is an important target of hypertension-induced organ damage. High cholesterol and triglyceride plasma levels have been demonstrated to be independent risk factors for progression of renal disease in humans. The aim of this study was to compare lipid metabolism parameters and renal function of hypertensive patients and a healthy control group. Our study included a group of 69 elderly patients with arterial hypertension (mean age ± S.D.: 66 ± 12 years) and a healthy control group made of 76 elderly subjects (mean age ± S.D: 67 ± 11 years) hospitalized in the IVth Medical Clinic of University of Medicine and Pharmacy “Victor Babes” Timisoara in a two years period. Their blood pressure (BP), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), serum uric acid, creatinine and blood urea nitrogen (BUN) levels were compared using the t Student`s test. Compared to controls, hypertensive elderly patients had higher levels of serum uric acid (6.7 ± 1.51 mg/dL vs. 6.6 ± 1.31 mg/dL, p=0.000166), creatinine (1.5 ± 0.309 mg/dL vs. 0.8 ± 0.18 mg/dL, p=0.026), urea (48 ± 10.58 mg/dL vs. 45 ±11.4 9 mg/dL, p<0.05), TC (257 ±45.37 mg/dL vs. 207 ± 51.89 mg/dL, p<0.05), LDL-C (216±52.27 mg/dL vs. 122 ± 57.09 mg/dL, p=0.032) and HDL-C (66 ± 12.23 mg/dL vs. 32 ± 7.56, p<0.05). TG in hypertensive patients (231±71.96 mg/dL) were significantly higher (p=0.0067) than in controls (135±69.31 mg/dL). A good correlation (r=0.066) was found between systolic blood pressure and LDL-cholesterol, despite therapy.
In this study we have shown that dyslipidemia affects a substantial proportion of hypertensive patients. Management of arterial hypertension should therefore focus both on lowering blood pressure and correcting associated lipid disorders. Treatment of elevated blood pressure not only reduces cardiovascular morbidity and mortality, but also reduces the incidence of renal failure as a consequence of hypertension-induced damage.
In this study we have shown that dyslipidemia affects a substantial proportion of hypertensive patients. Management of arterial hypertension should therefore focus both on lowering blood pressure and correcting associated lipid disorders. Treatment of elevated blood pressure not only reduces cardiovascular morbidity and mortality, but also reduces the incidence of renal failure as a consequence of hypertension-induced damage.
Research Interests:
Hypertensive cardiovascular disease is a systemic condition with potentially devastating long-term effects on vascular and end-organ function. The aim of this study was to compare renal parameters in hypertensive elderly patients (aged... more
Hypertensive cardiovascular disease is a systemic condition with potentially devastating long-term effects on vascular and end-organ function. The aim of this study was to compare renal parameters in hypertensive elderly patients (aged over 65 years) and in hypertensive adult patients (aged less than 65 years). The study comprised 20 elderly hypertensive patients (aged over 65 years) and 49 adult hypertensive patients (aged less than 65 years). Systolic blood pressure, diastolic blood pressure, total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum uric acid (SUA), creatinine and blood urea nitrogen (BUN) were determined in all patients. The parameters were compared in the two groups using the t Student`s test.
We compared the two groups: elderly and adult hypertensive patients, and we found statistical significant differences for the levels of blood urea nitrogen (48 ± 10.88 mg/dL vs. 47 ±8.93 mg/dL, p=0.023), and systolic blood pressure (175 ±24 mmHg vs. 160 ± 30 mmHg, p=0.0322). We found no significant statistical differences for diastolic blood pressure (105 ±9.43 mmHg vs. 100 ± 6.36 mmHg, p=0.44), triglycerides (231 ± 77.25 mg/dL vs. 149 ±49.66 mg/dL, p=0.42), total cholesterol (257 ± 50.97 mg/dL vs. 234 ±33.62 mg/dL, p=0.42), HDL-cholesterol (31 ± 7.31 mg/dL vs. 32 ±8.39 mg/dL, p=0.48), LDL-cholesterol (216 ± 51.6 mg/dL vs. 173 ±32.16 mg/dL, p=0.28), serum uric acid (6.3 ± 1.53 mg/dL vs. 6.9 ±1.75 mg/dL, p=0.57) and creatinine (1.5 ± 0.36 mg/dL vs. 0.9 ±0.17 mg/dL, p=0.30).The prevalence of elevated total cholesterol values was increased in the elderly hypertensive patients group (90%) compared to adult hypertensive patients (81.63%). The prevalence of elevated serum uric acid (10% vs. 6.122%) and urea (75% vs. 42.85%) were also higher in the elderly hypertensive group compared to the adult group.
Aging significantly increases urea and systolic blood pressure in hypertensive patients and impairs cholesterol metabolism. Hypertensive patients should be carefully monitored, to increase their lifespan and limit renal complications.
We compared the two groups: elderly and adult hypertensive patients, and we found statistical significant differences for the levels of blood urea nitrogen (48 ± 10.88 mg/dL vs. 47 ±8.93 mg/dL, p=0.023), and systolic blood pressure (175 ±24 mmHg vs. 160 ± 30 mmHg, p=0.0322). We found no significant statistical differences for diastolic blood pressure (105 ±9.43 mmHg vs. 100 ± 6.36 mmHg, p=0.44), triglycerides (231 ± 77.25 mg/dL vs. 149 ±49.66 mg/dL, p=0.42), total cholesterol (257 ± 50.97 mg/dL vs. 234 ±33.62 mg/dL, p=0.42), HDL-cholesterol (31 ± 7.31 mg/dL vs. 32 ±8.39 mg/dL, p=0.48), LDL-cholesterol (216 ± 51.6 mg/dL vs. 173 ±32.16 mg/dL, p=0.28), serum uric acid (6.3 ± 1.53 mg/dL vs. 6.9 ±1.75 mg/dL, p=0.57) and creatinine (1.5 ± 0.36 mg/dL vs. 0.9 ±0.17 mg/dL, p=0.30).The prevalence of elevated total cholesterol values was increased in the elderly hypertensive patients group (90%) compared to adult hypertensive patients (81.63%). The prevalence of elevated serum uric acid (10% vs. 6.122%) and urea (75% vs. 42.85%) were also higher in the elderly hypertensive group compared to the adult group.
Aging significantly increases urea and systolic blood pressure in hypertensive patients and impairs cholesterol metabolism. Hypertensive patients should be carefully monitored, to increase their lifespan and limit renal complications.
Research Interests:
Purpose: The aim of this study is represented by the assessment of the intrarenal vascularization, using color Doppler ultrasonography of the interlobar renal arteries. Material and methods: The study was performed on two groups of... more
Purpose: The aim of this study is represented by the assessment of the intrarenal vascularization, using color Doppler ultrasonography of the interlobar renal arteries.
Material and methods: The study was performed on two groups of pregnant women: group A, formed by 10 healthy pregnant women, and group B, formed by 10 pregnant women with preeclampsia. Assessment of the intrarenal vascularization was done by color Doppler ultrasonography of the interlobar renal arteries, using ALOKA 4000 SSD with 3.5 MHz convex transducer. Resistive index (RI), pulsatility index (PI), and acceleration time (AT) were determined in all cases. All data were expressed as mean ± standard deviation. Statistical analysis was done using Student’s t-test, p<0.05 was considered to be statistically significant.
Results: The mean age of patients was 32.15±3.41 years (group A), respective 34.02±5.01 years (group B), and the gestational age was 27.7±2.8 weeks (group A), respective 26.9±1.7 weeks (group B). The values of RI were 0.64±0.03 (group A), 0.65±0.02 (group B) (p>0.05). The values of PI were 1.13±0.06 (group A), 1.11±0.04 (group B) (p>0.05). The values of AT were 70.1±8.78 msec. (group A), 122.2±24.58 msec. (group B) (p<0.001).
Conclusion: In pregnant women with preeclampsia, resistive index and pulsatility index have normal values, but acceleration time is prolonged, due to arterial renal vasoconstriction.
Material and methods: The study was performed on two groups of pregnant women: group A, formed by 10 healthy pregnant women, and group B, formed by 10 pregnant women with preeclampsia. Assessment of the intrarenal vascularization was done by color Doppler ultrasonography of the interlobar renal arteries, using ALOKA 4000 SSD with 3.5 MHz convex transducer. Resistive index (RI), pulsatility index (PI), and acceleration time (AT) were determined in all cases. All data were expressed as mean ± standard deviation. Statistical analysis was done using Student’s t-test, p<0.05 was considered to be statistically significant.
Results: The mean age of patients was 32.15±3.41 years (group A), respective 34.02±5.01 years (group B), and the gestational age was 27.7±2.8 weeks (group A), respective 26.9±1.7 weeks (group B). The values of RI were 0.64±0.03 (group A), 0.65±0.02 (group B) (p>0.05). The values of PI were 1.13±0.06 (group A), 1.11±0.04 (group B) (p>0.05). The values of AT were 70.1±8.78 msec. (group A), 122.2±24.58 msec. (group B) (p<0.001).
Conclusion: In pregnant women with preeclampsia, resistive index and pulsatility index have normal values, but acceleration time is prolonged, due to arterial renal vasoconstriction.
Research Interests:
The antiphospholipid syndrome is an autoimmune disorder, which is characterized by pregnancy morbidity, recurrent arterial and/or venous thrombosis and persistently positive antiphospholipid antibodies (measured at least 12 weeks apart).... more
The antiphospholipid syndrome is an autoimmune disorder, which is characterized by pregnancy morbidity, recurrent arterial and/or venous thrombosis and persistently positive antiphospholipid antibodies (measured at least 12 weeks apart). The aim of this study was represented by the assessment of subclinical atherosclerosis in patients with primary antiphospholipid syndrome, using carotid artery ultrasonography and the characterization of the factors which contribute to its appearance. The study was performed on two groups of
subjects: group A, formed by 10 patients with primary antiphospholipid syndrome, and group B, formed by 10 healthy sex and age-matched controls. Antiphospholipid antibodies (EIA
method) were performed in patients with primary antiphospholipid syndrome, total cholesterol (Abbott photometry) was determined in all patients and control subjects. Carotid artery intima-media thickness and the presence of carotid plaques were determined using Bmode ultrasonography (ALOKA ProSound 4000, with linear transducer of 10 MHz). All the values were presented as mean ± standard deviation. The statistically analysis was done using Pearson’s test (for correlation) and Student’s t-test (for comparison), p < 0,05 was considered statistically significant. In patients with primary antiphospholipid syndrome, carotid artery intima-media thickness was increased than in controls (p < 0,001). The incidence of carotid artery plaques was greater in these patients (p < 0,05 ). Carotid artery intima-media thickness was correlated with antiphospholipid antibodies (r = 0,723, p< 0,01), total cholesterol (r =0,691, p< 0,05) and age (r = 0,628, p< 0,05). The patients with primary antiphospholipid syndrome may develop premature and accelerated atherosclerosis, antiphospholipid
antibodies being involved in its appearance.
subjects: group A, formed by 10 patients with primary antiphospholipid syndrome, and group B, formed by 10 healthy sex and age-matched controls. Antiphospholipid antibodies (EIA
method) were performed in patients with primary antiphospholipid syndrome, total cholesterol (Abbott photometry) was determined in all patients and control subjects. Carotid artery intima-media thickness and the presence of carotid plaques were determined using Bmode ultrasonography (ALOKA ProSound 4000, with linear transducer of 10 MHz). All the values were presented as mean ± standard deviation. The statistically analysis was done using Pearson’s test (for correlation) and Student’s t-test (for comparison), p < 0,05 was considered statistically significant. In patients with primary antiphospholipid syndrome, carotid artery intima-media thickness was increased than in controls (p < 0,001). The incidence of carotid artery plaques was greater in these patients (p < 0,05 ). Carotid artery intima-media thickness was correlated with antiphospholipid antibodies (r = 0,723, p< 0,01), total cholesterol (r =0,691, p< 0,05) and age (r = 0,628, p< 0,05). The patients with primary antiphospholipid syndrome may develop premature and accelerated atherosclerosis, antiphospholipid
antibodies being involved in its appearance.
Research Interests:
Introduction: Colonoscopy is a maximum accuracy diagnosis method for colorectal cancer and polyps, allowing multiple and guided biopsy of the observed lesions in the colonic lumen, but also the resection of the polyps. Aim: The purpose of... more
Introduction: Colonoscopy is a maximum accuracy diagnosis method for colorectal cancer and polyps, allowing multiple and guided biopsy of the observed lesions in the colonic lumen, but also the resection of the polyps. Aim: The purpose of this study was to perform an retrospective analyses of dates obtained from colonoscopy in order to create a mathematical model (risk calculator) which allows the selection of the patients with the highest probability to develop colorectal cancer. Matherial and methods: Dates from 2780 colonoscopies done in Timisoara County Clinical Emergency Hospital, during the period January 2005 to December 2008 were scrutinized. Results: 321 (11.5%) patients have had cancer. The classification of this group of 321 cancer cases by sex, has shown an increased incidence for men 193 (60.2 %) cases. The incidence of colorectal cancer increases with age. Based on our statistic results and other studies developed in the world, we developed a mathematical prediction scheme for the colorectal cancer risk. The mathematical prediction scheme considers: age, sex, weigh, height, personal history for polyps, and familial history of colorectal cancer, diet composition, physical activity and obesity. Conclusions: The development of this risk calculator for the colorectal cancer allows the selection of those particular subjects that have the highest probability for a colonic pathology, so that they would be the first to benefit from colonoscopy, without being necessary to use other screening methods.
Research Interests:
Aim: Contrast-Enhanced Ultrasound (CEUS) is an imaging method that can discriminate between hepatocellular carcinoma (HCC) and other liver lesions. The purpose of this study is to present our experience concerning the use of CEUS in the... more
Aim: Contrast-Enhanced Ultrasound (CEUS) is an imaging method that can discriminate between hepatocellular carcinoma
(HCC) and other liver lesions. The purpose of this study is to present our experience concerning the use of CEUS in the characterization of HCCs. Material and method: We included in our study all the patients evaluated in our Department from September 2009 to October 2010, with focal liver lesions (FLLs) on abdominal ultrasound (US) that were diagnosed as HCCs after CEUS examination, also patients with chronic liver disease with focal liver lesions highly suspected to be HCCs but with an inconclusive pattern on CEUS. One hundred patients with 148 HCCs were included. The enhancement pattern of the nodules was evaluated according to the 2008 EFSUMB Guidelines. Nodules displaying arterial hyperenhancement with “washout” in the portal/venous phase on CEUS were considered diagnostic for HCC. Nodules considered indeterminate after CEUS were evaluated by contrast-enhanced CT or MRI for diagnosis. Results: Among the 100 patients included, 96 were patients with chronic liver disease and 4 were patients without known liver disease. 71 patients had a solitary nodule, 16 patients had two nodules and 13 patients had three or more nodules. 112 HCCs had a typical enhancement pattern and 36 nodules were considered indeterminate after CEUS and were sent to CT/ MRI for diagnosis.
Conclusions: 75.7% of the studied liver nodules were diagnosed by CEUS as HCCs, thus CEUS is an easy method, convenient to
perform, avoiding other expensive examinations.
(HCC) and other liver lesions. The purpose of this study is to present our experience concerning the use of CEUS in the characterization of HCCs. Material and method: We included in our study all the patients evaluated in our Department from September 2009 to October 2010, with focal liver lesions (FLLs) on abdominal ultrasound (US) that were diagnosed as HCCs after CEUS examination, also patients with chronic liver disease with focal liver lesions highly suspected to be HCCs but with an inconclusive pattern on CEUS. One hundred patients with 148 HCCs were included. The enhancement pattern of the nodules was evaluated according to the 2008 EFSUMB Guidelines. Nodules displaying arterial hyperenhancement with “washout” in the portal/venous phase on CEUS were considered diagnostic for HCC. Nodules considered indeterminate after CEUS were evaluated by contrast-enhanced CT or MRI for diagnosis. Results: Among the 100 patients included, 96 were patients with chronic liver disease and 4 were patients without known liver disease. 71 patients had a solitary nodule, 16 patients had two nodules and 13 patients had three or more nodules. 112 HCCs had a typical enhancement pattern and 36 nodules were considered indeterminate after CEUS and were sent to CT/ MRI for diagnosis.
Conclusions: 75.7% of the studied liver nodules were diagnosed by CEUS as HCCs, thus CEUS is an easy method, convenient to
perform, avoiding other expensive examinations.
Research Interests:
Introduction: Colonoscopy is a maximum accuracy diagnosis method for colorectal cancer and polyps, allowing multiple and guided biopsy of the observed lesions in the colonic lumen, but also the resection of the polyps. Aim: The purpose of... more
Introduction: Colonoscopy is a maximum accuracy diagnosis method for colorectal cancer and polyps, allowing multiple and guided biopsy of the observed lesions in the colonic lumen, but also the resection of the polyps. Aim: The purpose of this study was to perform an retrospective analyses of dates obtained from colonoscopy in order to create a mathematical model (risk calculator) which allows the selection of the patients with the highest probability to develop colorectal cancer. Matherial and methods: Dates from 2780 colonoscopies done in Timisoara County Clinical Emergency Hospital, during the period January 2005 to December 2008 were scrutinized. Results: 321 (11.5%) patients have had cancer. The classification of this group of 321 cancer cases by sex, has shown an increased incidence for men 193 (60.2 %) cases. The incidence of colorectal cancer increases with age. Based on our statistic results and other studies developed in the world, we developed a mathematical prediction scheme for the colorectal cancer risk. The mathematical prediction scheme considers: age, sex, weigh, height, personal history for polyps, and familial history of colorectal cancer, diet composition, physical activity and obesity. Conclusions: The development of this risk calculator for the colorectal cancer allows the selection of those particular subjects that have the highest probability for a colonic pathology, so that they would be the first to benefit from colonoscopy, without being necessary to use other screening methods.
Research Interests:
Colonic polyps are slow-growing overgrowths of the colonic mucosa that carry a small risk (<1%) of becoming malignant. The aim of our study was to assess the profile of colonic polyps in the colon cancer patients hospitalized during a one... more
Colonic polyps are slow-growing overgrowths of the colonic mucosa that carry a small risk (<1%) of becoming malignant. The aim of our study was to assess the profile of colonic polyps in the colon cancer patients hospitalized during a one year period in Clinical County Hospital of Timisoara. Data from 795 colonoscopies done in our department during the period January 1, 2008 to December 31, 2008 were scrutinized and 183 cases with polyps were selected for this study. For each patient, age, sex, anatomic location of polyps at the level of the colon and morphological details of the polyps were recorded. The sex repartition of the patients was 43.4% men and 56.6% women. A progressive, linear increase of the percentage of the adenomatous polyps was noticed depending on the
age of the patients. The most frequently affected, 33.96%, was the age group between 50- 59 years. We followed the anatomic distribution of these polyps at the level of the colon: cecum 6.16%, ascending colon 9.06%, hepatic flexure 2.17%, transverse colon 15.22%, splenic flexure 2.54%, descending colon 5.79%, sigmoid 39.85 %, rectosigmoidian junction 2.54%, rectum 16.67%. Dimensions of the polyps were: 33.96% < 5 mm, 38.21% were between 5-10 mm, 17.93% were between 11-20 mm and 9.9% of them were > 20 mm. Complications of colonic polyps include bleeding, obstruction, diarrhea, and
development of cancer. Colonoscopy is a valuable method of diagnosing colonic polyps. Screening programs are essentially for early cancer diagnosis and for a proper treatment, especially in patients with risk of developing colon cancer.
age of the patients. The most frequently affected, 33.96%, was the age group between 50- 59 years. We followed the anatomic distribution of these polyps at the level of the colon: cecum 6.16%, ascending colon 9.06%, hepatic flexure 2.17%, transverse colon 15.22%, splenic flexure 2.54%, descending colon 5.79%, sigmoid 39.85 %, rectosigmoidian junction 2.54%, rectum 16.67%. Dimensions of the polyps were: 33.96% < 5 mm, 38.21% were between 5-10 mm, 17.93% were between 11-20 mm and 9.9% of them were > 20 mm. Complications of colonic polyps include bleeding, obstruction, diarrhea, and
development of cancer. Colonoscopy is a valuable method of diagnosing colonic polyps. Screening programs are essentially for early cancer diagnosis and for a proper treatment, especially in patients with risk of developing colon cancer.
Research Interests:
Colonic polyps are slow-growing overgrowths of the colonic mucosa that carry a small risk (<1%) of becoming malignant. The aim of our study was to assess the profile of colonic polyps in the colon cancer patients hospitalized during a one... more
Colonic polyps are slow-growing overgrowths of the colonic mucosa that carry a small risk (<1%) of becoming malignant. The aim of our study was to assess the profile of colonic polyps in the colon cancer patients hospitalized during a one year period in Clinical County Hospital of Timisoara. Data from 795 colonoscopies done in our department during the period January 1, 2008 to December 31, 2008 were scrutinized and 183 cases with polyps were selected for this study. For each patient, age, sex, anatomic location of polyps at the level of the colon and morphological details of the polyps were recorded. The sex repartition of the patients was 43.4% men and 56.6% women. A progressive, linear increase of the percentage of the adenomatous polyps was noticed depending on the age of the patients. The most frequently affected, 33.96%, was the age group between 50-59 years. We followed the anatomic distribution of these polyps at the level of the colon:
cecum 6.16%, ascending colon 9.06%, hepatic flexure 2.17%, transverse colon 15.22%, splenic flexure 2.54%, descending colon 5.79%, sigmoid 39.85 %, rectosigmoidian junction 2.54%, rectum 16.67%. Dimensions of the polyps were: 33.96% < 5 mm, 38.21% were between 5-10 mm, 17.93% were between 11-20 mm and 9.9% of them were > 20 mm. Complications of colonic polyps include bleeding, obstruction, diarrhea, and
development of cancer. Colonoscopy is a valuable method of diagnosing colonic polyps. Screening programs are essentially for early cancer diagnosis and for a proper treatment,
especially in patients with risk of developing colon cancer.
cecum 6.16%, ascending colon 9.06%, hepatic flexure 2.17%, transverse colon 15.22%, splenic flexure 2.54%, descending colon 5.79%, sigmoid 39.85 %, rectosigmoidian junction 2.54%, rectum 16.67%. Dimensions of the polyps were: 33.96% < 5 mm, 38.21% were between 5-10 mm, 17.93% were between 11-20 mm and 9.9% of them were > 20 mm. Complications of colonic polyps include bleeding, obstruction, diarrhea, and
development of cancer. Colonoscopy is a valuable method of diagnosing colonic polyps. Screening programs are essentially for early cancer diagnosis and for a proper treatment,
especially in patients with risk of developing colon cancer.
Research Interests:
Carbohydrate-deficient transferrin (CDT) represents an important instrument for the evaluation process of alcohol consumption. But there is not a consensus on its use in the routine practice. The objective of this study was to compare... more
Carbohydrate-deficient transferrin (CDT) represents an important instrument for the evaluation process of alcohol consumption. But there is not a consensus on its use in the routine practice. The objective of this study was to compare carbohydrate-deficient transferrin and gammaglutamyl transpeptidase (GGT) assays for the evaluation of alcohol consumption. 165 patients (100 males and 65 females) were included in this study. Patients were divided into five categories according to alcohol consumption: category 1 included non-weaned patients drinking more than 30 g/day for women and more than 50 g/day for men, category 2 included relapse patients, category 3 included moderate drinkers, category 4 included patients weaned less than one month, and category 5 included patients weaned more than one month. A specifically standardized questionnaire was used. Blood samples were drawn at the alcohol-cure outpatient centre. Samples were drawn at the first consultation and later as prescribed depending on the clinical situation. Sensitivity of CDT varied, depending on patient category, from 36% to 96% versus 45% to 70% for GGT. Specificity of CDT varied from 72% to 90% versus 21% to 61% for GGT. This study shows that carbohydrate-deficient transferrin is more accurate in predicting alcohol consumption compared with gamma-glutamyl transpeptidase in alcoholic patients evaluation.