Evolution and Medicine
by Yale University
This course material is only available in the iTunes U app on iPhone or iPad.
Course Description
This course is a survey of evolutionary insights that make important differences in medical research and clinical practice, including evolutionary mechanisms and the medical issues they affect. Individual genetic variation in susceptibility; evolutionary conflicts and tradeoffs in reproductive medicine; the evolution of antibiotic resistance and virulence in pathogens; emerging diseases; the evolution of aging; cancer as an evolutionary process.
Prof. Stearns would like to acknowledge the support of both Yale and the National Evolutionary Synthesis Center (NESCent) for this Course. NESCent (http://www.nescent.org) is a nonprofit science center dedicated to promoting the synthesis of information, concepts and knowledge to address significant, emerging, or novel questions in evolutionary science and its applications. NESCent is jointly operated by Duke University, The University of North Carolina at Chapel Hill, and North Carolina State University, and is sponsored by the National Science Foundation.
| Name | Description | Time | Price | ||
|---|---|---|---|---|---|
| 1 | 1.1 Natural Selection | -- | 20:57 | Free | View in iTunes |
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2 |
1.1 Natural Selection | -- | 20:39 | Free | View in iTunes |
| 3 | Natural Selection Presentation | -- | -- | Free | View in iTunes |
| 4 | Measuring Selection in Contemporary Human Populations | -- | -- | Free | View in iTunes |
| 5 | Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division | -- | -- | Free | View in iTunes |
| 6 | Evidence for Evolution in Response to Natural Selection in a Contemporary Human Population | -- | -- | Free | View in iTunes |
| 7 | 1.2 Random Evolution | -- | 29:29 | Free | View in iTunes |
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8 |
1.2 Random Evolution | -- | 29:11 | Free | View in iTunes |
| 9 | Random Evolution Presentation | -- | -- | Free | View in iTunes |
| 10 | Measuring Selection in Contemporary Human Populations | -- | -- | Free | View in iTunes |
| 11 | 1.3 Mismatch | -- | 14:19 | Free | View in iTunes |
|
12 |
1.3 Mismatch | -- | 14:01 | Free | View in iTunes |
| 13 | Mismatch Presentation | -- | -- | Free | View in iTunes |
| 14 | 1.4 Adaptation | -- | 19:09 | Free | View in iTunes |
|
15 |
1.4 Adaptation | -- | 18:51 | Free | View in iTunes |
| 16 | Adaptation Presentation | -- | -- | Free | View in iTunes |
| 17 | 1.5 Types of Thinking | -- | 17:49 | Free | View in iTunes |
|
18 |
1.5 Types of Thinking | -- | 17:30 | Free | View in iTunes |
| 19 | Types of Thinking Presentation | -- | -- | Free | View in iTunes |
| 20 | 2.1 What is a Patient? - Ancient History | -- | 18:44 | Free | View in iTunes |
|
21 |
2.1 What is a patient? - Ancient History | -- | 18:26 | Free | View in iTunes |
| 22 | What is a Patient? Ancient History Presentation | -- | -- | Free | View in iTunes |
| 23 | The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme | -- | -- | Free | View in iTunes |
| 24 | 2.2 What is a Patient? - Recent History | -- | 19:08 | Free | View in iTunes |
|
25 |
2.2 What is a patient? Recent History | -- | 18:39 | Free | View in iTunes |
| 26 | What is a Patient? Recent History Presentation | -- | -- | Free | View in iTunes |
| 27 | 2.3 What is a Patient? - Genetic Variation for Disease Resistance | -- | 21:53 | Free | View in iTunes |
|
28 |
2.3 What is a patient? Genetic Variation for Disease Resistance | -- | 21:34 | Free | View in iTunes |
| 29 | What is a Patient? Variation in Disease Resistance Presentation | -- | -- | Free | View in iTunes |
| 30 | 2.4 What is a Patient? - Genetic Variation for Ability to Metabolize Drugs | -- | 16:54 | Free | View in iTunes |
|
31 |
2.4 What is a Patient? Genetic Variation for Ability to Metabolize Drugs | -- | 16:36 | Free | View in iTunes |
| 32 | What is a Patient? Variation in Drug Metabolism Presentation | -- | -- | Free | View in iTunes |
| 33 | 2.5 What is a Patient? - The Human Life History and its Evolution | -- | 19:26 | Free | View in iTunes |
|
34 |
2.5 What is a Patient? - The Human Life History and its Evolution | -- | 19:07 | Free | View in iTunes |
| 35 | What is a Patient? Life History Presentation | -- | -- | Free | View in iTunes |
| 36 | Genetic links between post-reproductive lifespan and family size in Framingham | -- | -- | Free | View in iTunes |
| 37 | 2.6 What is a patient? - Reaction Norms and Phenotypic Plasticity | -- | 15:48 | Free | View in iTunes |
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38 |
2.6 What is a patient? - Reaction Norms and Phenotypic Plasticity | -- | 15:29 | Free | View in iTunes |
| 39 | What is a Patient? Plasticity and reaction norms Presentation | -- | -- | Free | View in iTunes |
| 40 | 2.7 What is a patient? - A Bundle of Tradeoffs | -- | 19:49 | Free | View in iTunes |
|
41 |
2.7 What is a patient? A Bundle of Tradeoffs | -- | 19:31 | Free | View in iTunes |
| 42 | What is a Patient? Tradeoffs Presentation | -- | -- | Free | View in iTunes |
| 43 | 2.8 What is a patient? Someone Who Ages | -- | 18:59 | Free | View in iTunes |
|
44 |
2.8 What is a patient? Someone Who Ages | -- | 18:41 | Free | View in iTunes |
| 45 | What is a Patient? Someone Who Ages Presentation | -- | -- | Free | View in iTunes |
| 46 | 2.9: What is a patient? The Unusual Human Life History | -- | 23:26 | Free | View in iTunes |
|
47 |
2.9 What is a patient? The Unusual Human Life History | -- | 23:07 | Free | View in iTunes |
| 48 | What Is A Patient? The Unusual Human Life History Presentation | -- | -- | Free | View in iTunes |
| 49 | 2.10 What is a patient? The Developmental Origins of Disease | -- | 14:58 | Free | View in iTunes |
|
50 |
2.10 What is a patient? The Developmental Origins of Disease | -- | 14:39 | Free | View in iTunes |
| 51 | What Is A Patient? Developmental Origins of the Metabolic Syndrome Presentation | -- | -- | Free | View in iTunes |
| 52 | 2.11 What is a patient? The Microbiome | -- | 18:19 | Free | View in iTunes |
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53 |
2.11 What is a patient? The Microbiome | -- | 18:00 | Free | View in iTunes |
| 54 | What Is A Patient? Developmental Origins of the Microbiome Presentation | -- | -- | Free | View in iTunes |
| 55 | A meta-analysis of the association between Caesarean section and childhood asthma | -- | -- | Free | View in iTunes |
| 56 | Reciprocal interactions of the intestinal microbiota and immune system | -- | -- | Free | View in iTunes |
| 57 | 2.12 What is a patient? Summary | -- | 6:24 | Free | View in iTunes |
|
58 |
2.12 What is a patient? Summary | -- | 6:04 | Free | View in iTunes |
| 59 | What Is A Patient? Recap Presentation | -- | -- | Free | View in iTunes |
| 60 | 3.1 What is a disease? Introduction | -- | 13:37 | Free | View in iTunes |
|
61 |
3.1 What is a disease? Introduction | -- | 13:18 | Free | View in iTunes |
| 62 | What Is A Disease? Introduction Presentation | -- | -- | Free | View in iTunes |
| 63 | 3.2 What is a Disease? Vulnerable vs. Robust Tissues and Organs | -- | 13:08 | Free | View in iTunes |
|
64 |
3.2 What is a Disease? Vulnerable vs. Robust Tissues and Organs | -- | 12:49 | Free | View in iTunes |
| 65 | What Is A Disease? Vulnerable to Robust Organs Presentation | -- | -- | Free | View in iTunes |
| 66 | 3.3 What is a Disease? From Fixed to Adjustable Reactions | -- | 8:19 | Free | View in iTunes |
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67 |
3.3 What is a Disease? From Fixed to Adjustable Reactions | -- | 7:59 | Free | View in iTunes |
| 68 | What Is A Disease? Fixed to Adjustable Reactions Presentation | -- | -- | Free | View in iTunes |
| 69 | 3.4 What is a Disease? History and Mismatch | -- | 23:30 | Free | View in iTunes |
|
70 |
3.4 What is a Disease? History and Mismatch | -- | 23:12 | Free | View in iTunes |
| 71 | What Is A Disease? History and Mismatch Presentation | -- | -- | Free | View in iTunes |
| 72 | 4.1 Defenses: Origins and Costs | -- | 13:00 | Free | View in iTunes |
|
73 |
4.1 Defenses: Origins and Costs | -- | 12:41 | Free | View in iTunes |
| 74 | Defenses: Origin and Costs Presentation | -- | -- | Free | View in iTunes |
| 75 | Evolution of Inflammatory Diseases | -- | -- | Free | View in iTunes |
| 76 | 4.2 Defenses: Specialized | -- | 29:29 | Free | View in iTunes |
|
77 |
4.2 Defenses: Specialized | -- | 29:10 | Free | View in iTunes |
| 78 | Defenses: Specialized Defenses Presentation | -- | -- | Free | View in iTunes |
| 79 | 4.3 Defenses: Key Characteristics | -- | 15:34 | Free | View in iTunes |
|
80 |
4.3 Defenses: Key Characteristics | -- | 15:16 | Free | View in iTunes |
| 81 | Defenses: Key Characteristics Presentation | -- | -- | Free | View in iTunes |
| 82 | 4.4 Defenses: The Major Strategies | -- | 13:10 | Free | View in iTunes |
|
83 |
4.4 Defenses: The Major Strategies | -- | 12:50 | Free | View in iTunes |
| 84 | Defenses: The Major Strategies Presentation | -- | -- | Free | View in iTunes |
| 85 | 4.5 Defenses: Tolerance | -- | 15:58 | Free | View in iTunes |
|
86 |
4.5 Defenses: Tolerance | -- | 15:40 | Free | View in iTunes |
| 87 | Defenses: Tolerance Presentation | -- | -- | Free | View in iTunes |
| 88 | 4.6 Defenses: Evolution of the Vertebrate Immune System | -- | 22:13 | Free | View in iTunes |
|
89 |
4.6 Defenses: Evolution of the Vertebrate Immune System | -- | 21:55 | Free | View in iTunes |
| 90 | Defenses: Evolution of Immunity I Presentation | -- | -- | Free | View in iTunes |
| 91 | 4.7 Defenses: More Detail on the Vertebrate Immune Response | -- | 21:10 | Free | View in iTunes |
|
92 |
4.7 Defenses: More Detail on the Vertebrate Immune Response | -- | 20:51 | Free | View in iTunes |
| 93 | Defenses: More Detail on the Vertebrate Immune Response Presentation | -- | -- | Free | View in iTunes |
| 94 | 4.8 Defenses: Managing the Microbiome – Symbionts vs. Pathogens | -- | 15:13 | Free | View in iTunes |
|
95 |
4.8 Defenses: Managing the Microbiome – Symbionts vs. Pathogens | -- | 14:54 | Free | View in iTunes |
| 96 | Defenses: Evolution of Host-Microbe Interactions Presentation | -- | -- | Free | View in iTunes |
| 97 | 5.1 Pathogen Evolution: Virulence | -- | 19:26 | Free | View in iTunes |
|
98 |
5.1 Pathogen Evolution: Virulence | -- | 19:07 | Free | View in iTunes |
| 99 | Pathogen Evolution: Virulence Presentation | -- | -- | Free | View in iTunes |
| 100 | 5.2 Pathogen Evolution: Evasion of Host Defenses | -- | 19:08 | Free | View in iTunes |
|
101 |
5.2 Pathogen Evolution: Evasion of Host Defenses | -- | 18:48 | Free | View in iTunes |
| 102 | Pathogen Evolution: Evasion Presentation | -- | -- | Free | View in iTunes |
| 103 | 5.3 Pathogen Evolution: Antibiotic Resistance | -- | 13:56 | Free | View in iTunes |
|
104 |
5.3 Pathogen Evolution: Antibiotic Resistance | -- | 13:36 | Free | View in iTunes |
| 105 | Pathogen Evolution: Resistance Presentation | -- | -- | Free | View in iTunes |
| 106 | 5.4 Pathogen Evolution: Evolution-Proof Therapies | -- | 13:57 | Free | View in iTunes |
|
107 |
5.4 Pathogen Evolution: Evolution-Proof Therapies | -- | 13:38 | Free | View in iTunes |
| 108 | Pathogen Evolution: Evolution-Proof Therapies Presentation | -- | -- | Free | View in iTunes |
| 109 | 6.1 The Evolution of Reproduction: Mammalian Reproduction | -- | 26:43 | Free | View in iTunes |
|
110 |
6.1 The Evolution of Reproduction: Mammalian Reproduction | -- | 26:24 | Free | View in iTunes |
| 111 | Evolution of Mammalian Reproduction Presentation | -- | -- | Free | View in iTunes |
| 112 | 6.2 The Evolution of Reproduction: Invasive Placentas | -- | 17:24 | Free | View in iTunes |
|
113 |
6.2 The Evolution of Reproduction: Invasive Placentas | -- | 17:05 | Free | View in iTunes |
| 114 | Evolution of Invasive Placentas Presentation | -- | -- | Free | View in iTunes |
| 115 | 6.3 The Evolution of Reproduction: Evolutionary Conflict | -- | 14:25 | Free | View in iTunes |
|
116 |
6.3 The Evolution of Reproduction: Evolutionary Conflict | -- | 14:06 | Free | View in iTunes |
| 117 | Evolutionary Conflict Presentation | -- | -- | Free | View in iTunes |
| 118 | 6.4 The Evolution of Reproduction: Genomic Conflict and Mental Health | -- | 13:45 | Free | View in iTunes |
|
119 |
6.4 The Evolution of Reproduction: Genomic Conflict and Mental Health | -- | 13:26 | Free | View in iTunes |
| 120 | Genomic Conflict and Mental Health Presentation | -- | -- | Free | View in iTunes |
| 121 | The evolution of menstruation: a new model for genetic assimilation: explaining molecular origins of maternal responses to fetal | -- | -- | Free | View in iTunes |
| 122 | 6.5 The Evolution of Reproduction: Menstruation and Menopause | -- | 14:49 | Free | View in iTunes |
|
123 |
6.5 The Evolution of Reproduction: Menstruation and Menopause | -- | 14:30 | Free | View in iTunes |
| 124 | Menstruation and Menopause Presentation | -- | -- | Free | View in iTunes |
| 125 | 6.6 The Evolution of Reproduction: Upright Posture and Childbirth | -- | 11:31 | Free | View in iTunes |
|
126 |
6.6 The Evolution of Reproduction: Upright Posture and Childbirth | -- | 11:12 | Free | View in iTunes |
| 127 | Upright Posture and Childbirth Presentation | -- | -- | Free | View in iTunes |
| 128 | 7.1 Cancer as an Evolutionary Process: Introduction | -- | 11:23 | Free | View in iTunes |
|
129 |
7.1 Cancer as an Evolutionary Process: Introduction | -- | 11:05 | Free | View in iTunes |
| 130 | Cancer: Introduction Presentation | -- | -- | Free | View in iTunes |
| 131 | 7.2 Cancer as an Evolutionary Process: Why we are Susceptible | -- | 18:28 | Free | View in iTunes |
|
132 |
7.2 Cancer as an Evolutionary Process: Why we are Susceptible | -- | 18:10 | Free | View in iTunes |
| 133 | Cancer: Susceptibility Presentation | -- | -- | Free | View in iTunes |
| 134 | 7.3 Cancer as an Evolutionary Process: Clonal Evolution | -- | 17:11 | Free | View in iTunes |
|
135 |
7.3 Cancer as an Evolutionary Process: Clonal Evolution | -- | 16:53 | Free | View in iTunes |
| 136 | Cancer: Clonal Evolution Presentation | -- | -- | Free | View in iTunes |
| 137 | 7.4 Cancer as an Evolutionary Process: Phylogenetics | -- | 14:32 | Free | View in iTunes |
|
138 |
7.4 Cancer as an Evolutionary Process: Phylogenetics | -- | 14:13 | Free | View in iTunes |
| 139 | Cancer: Phylogenetics Presentation | -- | -- | Free | View in iTunes |
| 140 | Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer | -- | -- | Free | View in iTunes |
| 141 | 7.5 Cancer as an Evolutionary Process: Immune Evasion | -- | 15:57 | Free | View in iTunes |
|
142 |
7.5 Cancer as an Evolutionary Process: Immune Evasion | -- | 15:38 | Free | View in iTunes |
| 143 | Cancer: Immune Evasion Presentation | -- | -- | Free | View in iTunes |
| 144 | 7.6 Cancer as an Evolutionary Process: Managing Chemotherapy | -- | 16:15 | Free | View in iTunes |
|
145 |
7.6 Cancer as an Evolutionary Process: Managing Chemotherapy | -- | 15:56 | Free | View in iTunes |
| 146 | Cancer: Chemotherapy Presentation | -- | -- | Free | View in iTunes |
| 146 Items |
