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ADAM2

Identifiers

ADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2

External IDs

OMIM: 601533 MGI: 1340894 HomoloGene: 1127 GeneCards: ADAM2

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p11.22	Start	39,743,735 bp^[1]
Band	8p11.22	End	39,838,227 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 D1\|14 34.36 cM	Start	66,264,778 bp^[2]
Band	14 D1\|14 34.36 cM	End	66,315,182 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

placenta

monocyte

prostate

appendix

prefrontal cortex

hypothalamus

hippocampus proper

human musculoskeletal system

muscle of leg

Top expressed in

spermatocyte

spermatid

seminiferous tubule

morula

blastocyst

duodenum

neural tube

endocrine system

islet of Langerhans

digastric muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	integrin binding metalloendopeptidase activity metallopeptidase activity
Cellular component	integral component of membrane cell surface plasma membrane integral component of plasma membrane membrane protein-containing complex
Biological process	visual learning fusion of sperm to egg plasma membrane involved in single fertilization cell adhesion adult behavior proteolysis binding of sperm to zona pellucida single fertilization positive regulation of gene expression
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2515


11495

Ensembl


ENSG00000104755 ENSG00000276286


ENSMUSG00000022039

UniProt


Q99965


Q60718

RefSeq (mRNA)


NM_001278113 NM_001278114 NM_001464


NM_009618

RefSeq (protein)


NP_001265042 NP_001265043 NP_001455


NP_033748

Location (UCSC)

Chr 8: 39.74 – 39.84 Mb

Chr 14: 66.26 – 66.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin^[5] is an enzyme that in humans is encoded by the ADAM2 gene.^[6]^[7]^[8]

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Transcription

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.^[8] The other subunit is ADAM1 or alpha-fertilin.^[5]

References

^ ^a ^b ^c ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022039 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.
^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
^ ^a ^b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

External links

The MEROPS online database for peptidases and their inhibitors: M12.950
Human ADAM2 genome location and ADAM2 gene details page in the UCSC Genome Browser.

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 28 November 2023, at 02:54