BBC Russian

BRAP

Identifiers

BRAP, BRAP2, IMP, RNF52, BRCA1 associated protein

External IDs

OMIM: 604986; MGI: 1919649; HomoloGene: 4926; GeneCards: BRAP; OMA:BRAP - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.12	Start	111,642,146 bp^[1]
Band	12q24.12	End	111,685,956 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	121,798,626 bp^[2]
Band	5\|5 F	End	121,825,319 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

sperm

Achilles tendon

gastrocnemius muscle

islet of Langerhans

blood

optic nerve

stromal cell of endometrium

amniotic fluid

ganglionic eminence

Top expressed in

spermatid

spermatocyte

seminiferous tubule

secondary oocyte

left lobe of liver

proximal tubule

entorhinal cortex

kidney

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	ubiquitin protein ligase activity zinc ion binding metal ion binding ubiquitin-protein transferase activity protein binding nuclear localization sequence binding identical protein binding nucleic acid binding transferase activity
Cellular component	cytoplasm nuclear membrane ubiquitin ligase complex cytosol
Biological process	MAPK cascade protein ubiquitination negative regulation of signal transduction Ras protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8315


72399

Ensembl


ENSG00000089234


ENSMUSG00000029458

UniProt


Q7Z569


Q99MP8

RefSeq (mRNA)


NM_006768


NM_001289543 NM_001289544 NM_028227

RefSeq (protein)


NP_006759


NP_001276472 NP_001276473 NP_082503

Location (UCSC)

Chr 12: 111.64 – 111.69 Mb

Chr 5: 121.8 – 121.83 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene. ^[5]

Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089234 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029458 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: BRCA1 associated protein". Retrieved 2018-03-23.

Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (January 2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID 14724641. S2CID 4416552.
Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S (September 2004). "Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation". Mol. Cell. Biol. 24 (18): 8236–43. doi:10.1128/MCB.24.18.8236-8243.2004. PMC 515069. PMID 15340083.
Chen C, Lewis RE, White MA (May 2008). "IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds". J. Biol. Chem. 283 (19): 12789–96. doi:10.1074/jbc.M709305200. PMC 2442335. PMID 18332145.
Mallin EA, Pavlicek W (April 2008). "55-year-old woman with menopausal symptoms and a family history of breast cancer". Mayo Clin. Proc. 83 (4): 485–8. doi:10.4065/83.4.485. PMID 18380995.
Czyzyk J, Chen HC, Bottomly K, Flavell RA (August 2008). "p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells". J. Biol. Chem. 283 (34): 23004–15. doi:10.1074/jbc.M804084200. PMC 2516986. PMID 18577512.
Keinan-Boker L, Lerner-Geva L, Kaufman B, Meirow D (October 2008). "Pregnancy-associated breast cancer". Isr. Med. Assoc. J. 10 (10): 722–7. PMID 19009954.
Chen JS, Hu HY, Zhang S, He M, Hu RM (May 2009). "Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification". Biotechnol. Lett. 31 (5): 615–21. doi:10.1007/s10529-009-9914-7. PMID 19152073. S2CID 22550914.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 6 December 2022, at 06:01

BRAP (gene)

From Wikipedia, the free encyclopedia

Function

References

Further reading