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A biphasic disease is a disease which has two distinct phases or components. In clinically biphasic diseases, the phases are generally chronologically separated. In histopathologically biphasic tumors (also called biplastic tumors), there is neoplastic tissue which contains two different cellular elements.^[1]^[2]

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Examples

Clinically biphasic diseases

Disease	Typical first phase	Typical second phase
European (or "Western") subtype of tick-borne encephalitis virus^[3]^[4]	Relatively mild flu-like illness	Affecting some cases, generally presenting with high fever and neurologic disease (encephalitis), meningitis and/or meningoencephalitis)
Leptospirosis^[5]	4–9 days of abrupt onset of flu-like illness	Fever, jaundice, abdominal pain and diarrhoea. Organ failure in severe cases.
Anthrax^[6]	After approximately 4 days, patients develop flu-like illness with fever, nonproductive cough, and myalgias lasting approximately 4 days	Without timely treatment, a second fulminant phase follows, characterized by hypotension and dyspnea. This phase may progress to death within 24 hours of its onset.^[6]

Tumor biplasia

Disease	Cellular elements
Fibroadenoma^[1]^[7]	Epithelium	Stroma
Ceruminous adenoma^[8]	Inner luminal secretory cells	Myoepithelial cells

References

^ ^a ^b Salati SA (2020). "Breast fibroadenomas: a review in the light of current literature". Pol Przegl Chir. 93 (1): 40–48. doi:10.5604/01.3001.0014.5676. PMID 33729177. S2CID 232262405.
^ Babu R S A, Reddy B V R, C H A (February 2014). "Histogenetic concepts, terminology and categorization of biphasic tumours of the oral and maxillofacial region". Journal of Clinical and Diagnostic Research. 8 (2): 266–270. doi:10.7860/JCDR/2014/7506.4078. PMC 3972583. PMID 24701553.
^ Veje M, Studahl M, Johansson M, Johansson P, Nolskog P, Bergström T (February 2018). "Diagnosing tick-borne encephalitis: a re-evaluation of notified cases". European Journal of Clinical Microbiology & Infectious Diseases. 37 (2): 339–344. doi:10.1007/s10096-017-3139-9. PMC 5780526. PMID 29188467.
^ Kaiser R (September 2008). "Tick-Borne Encephalitis". Infectious Disease Clinics of North America. 22 (3): 561–575. doi:10.1016/j.idc.2008.03.013. PMID 18755391.
^ "Factsheet about leptospirosis". European Centre for Disease Prevention and Control. 16 July 2010. Page last updated 26 Jun 2017
^ ^a ^b Sweeney DA, Hicks CW, Cui X, Li Y, Eichacker PQ (15 December 2011). "Anthrax Infection". American Journal of Respiratory and Critical Care Medicine. 184 (12): 1333–1341. doi:10.1164/rccm.201102-0209CI. PMC 3361358. PMID 21852539.
^ Tavassoli F, Devilee P, eds. (2003). World Health Organization Classification of Tumours: Pathology & Genetics: Tumours of the breast and female genital organs. Lyon: IARC Press. ISBN 978-92-832-2412-9.^{[page needed]}
^ Thompson LD, Nelson BL, Barnes EL (Mar 2004). "Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature". Am J Surg Pathol. 28 (3): 308–18. doi:10.1097/00000478-200403000-00003. PMID 15104293. S2CID 27571673.

This page was last edited on 20 June 2024, at 03:48

Biphasic disease

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