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CGS-9896

From Wikipedia, the free encyclopedia

CGS-9896
Clinical data
ATC code
  • none
Identifiers
  • 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
CAS Number
Chemical and physical data
FormulaC16H10ClN3O
Molar mass295.73 g·mol−1
3D model (JSmol)
  • C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
  • InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H ☒N
  • Key:QCBUAKLOWCOUCR-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

CGS-9896 is a benzodiazepine receptor partial agonist which produces long-lasting anxiolytic and anticonvulsant effects in animal studies but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5]

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Transcription

References

  1. ^ Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID 2854261. S2CID 21773709.
  2. ^ J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01259406. PMID 3343593. S2CID 31525533.
  3. ^ Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch. Toxicol. 64 (5): 412–3. doi:10.1007/BF01973465. PMID 2206111. S2CID 19084019.
  4. ^ Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2–3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. S2CID 32809713.
  5. ^ Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID 2109664. S2CID 37492286.


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This page was last edited on 9 January 2023, at 10:07
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