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Chloride channel protein 2 is a protein that in humans is encoded by the CLCN2gene.[5][6] Mutations of this gene have been found to cause leukoencephalopathy[7] and Idiopathic generalised epilepsy (OMIM: 600699),[8] although the latter claim has been disputed.[9] CLCN2 contains a transmembrane region that is involved in chloride ion transport as well two intracellular copies of the CBS domain.
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cid LP, Montrose-Rafizadeh C, Smith DI, Guggino WB, Cutting GR (March 1995). "Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues". Human Molecular Genetics. 4 (3): 407–13. doi:10.1093/hmg/4.3.407. PMID7795595.
^Combi R, Grioni D, Contri M, Redaelli S, Redaelli F, Bassi MT, et al. (April 2009). "Clinical and genetic familial study of a large cohort of Italian children with idiopathic epilepsy". Brain Research Bulletin. 79 (2): 89–96. doi:10.1016/j.brainresbull.2009.01.008. PMID19200853. S2CID3036929.
Lamb FS, Clayton GH, Liu BX, Smith RL, Barna TJ, Schutte BC (March 1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". Journal of Molecular and Cellular Cardiology. 31 (3): 657–66. doi:10.1006/jmcc.1998.0901. PMID10198195.
Lamb FS, Graeff RW, Clayton GH, Smith RL, Schutte BC, McCray PB (April 2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". American Journal of Respiratory Cell and Molecular Biology. 24 (4): 376–81. doi:10.1165/ajrcmb.24.4.4114. PMID11306429.
Lipecka J, Bali M, Thomas A, Fanen P, Edelman A, Fritsch J (April 2002). "Distribution of ClC-2 chloride channel in rat and human epithelial tissues". American Journal of Physiology. Cell Physiology. 282 (4): C805-16. doi:10.1152/ajpcell.00291.2001. PMID11880269.
Chu S, Blaisdell CJ, Bamford P, Ferro TJ (November 2004). "Interferon-gamma regulates ClC-2 chloride channel in lung epithelial cells". Biochemical and Biophysical Research Communications. 324 (1): 31–9. doi:10.1016/j.bbrc.2004.09.026. PMID15464978.
D'Agostino D, Bertelli M, Gallo S, Cecchin S, Albiero E, Garofalo PG, et al. (October 2004). "Mutations and polymorphisms of the CLCN2 gene in idiopathic epilepsy". Neurology. 63 (8): 1500–2. doi:10.1212/01.wnl.0000142093.94998.1a. PMID15505175. S2CID46730230.
Heils A (2004). "CLCN2 and idiopathic generalized epilepsy". Advances in Neurology. 95: 265–71. PMID15508929.
Hinzpeter A, Lipecka J, Brouillard F, Baudoin-Legros M, Dadlez M, Edelman A, Fritsch J (January 2006). "Association between Hsp90 and the ClC-2 chloride channel upregulates channel function". American Journal of Physiology. Cell Physiology. 290 (1): C45-56. CiteSeerX10.1.1.533.5601. doi:10.1152/ajpcell.00209.2005. PMID16049054. S2CID8655480.
This page was last edited on 11 December 2023, at 10:07