Exfoliatin is a Staphylococcus aureus exotoxin[1] that causes a blistering of the skin known as staphylococcal scalded skin syndrome, usually in infants.[2]
Exfoliatins are glutamate-specific serine proteases highly specific to desmoglein I, a cadherin (adhesion protein) in the desmosomes of the stratum granulosum that facilitates intercellular adhesion between keratinocytes. The resulting vesicle is an intraepidermal cleft located above the basal cells (suprabasal), between the stratum corneum and stratum spinosum. Desmoglein-1 is similarly involved in Pemphigus foliaceus, an auto-immune skin condition. A very similar non-infectious condition is seen in the autoimmune skin disorder pemphigus vulgaris in which there is an IgG antibody against the cadherin desmoglein 3.
YouTube Encyclopedic
-
1/3Views:30 4583463 546
-
Staphylococcal Scalded Skin Syndrome (SSSS) and Bullous Impetigo
-
staphylococcal scalded skin syndrome
-
4 (3-9) Staphylococcus aureus - Virulence factors & Pathogenesis عوامل الضراوة والإمراضية
Transcription
See also
References
- ^ Exfoliatins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ "exfoliatin""at Dorland's Medical Dictionary
This page was last edited on 21 September 2023, at 21:27