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ARHGEF25

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2RGN

Identifiers

Aliases

ARHGEF25, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25

External IDs

OMIM: 610215 MGI: 1277173 HomoloGene: 32691 GeneCards: ARHGEF25

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.3	Start	57,610,180 bp^[1]
Band	12q13.3	End	57,617,245 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 D3\|10 74.5 cM	Start	127,018,394 bp^[2]
Band	10 D3\|10 74.5 cM	End	127,025,952 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right coronary artery

gastric mucosa

popliteal artery

left uterine tube

myometrium

thoracic aorta

ascending aorta

left coronary artery

superior frontal gyrus

smooth muscle tissue

Top expressed in

hippocampus proper

primary motor cortex

superior frontal gyrus

vas deferens

Region I of hippocampus proper

belly cord

prefrontal cortex

piriform cortex

internal carotid artery

external carotid artery

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity
Cellular component	cytoplasm cytosol plasma membrane myofibril sarcomere membrane
Biological process	regulation of Rho protein signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


115557


52666

Ensembl


ENSG00000240771


ENSMUSG00000019467

UniProt


Q86VW2


Q9CWR0

RefSeq (mRNA)


NM_001111270 NM_133483 NM_182947 NM_001347933


NM_001166413 NM_028027 NM_001358557 NM_001358558

RefSeq (protein)


NP_001104740 NP_891992 NP_001334862


NP_001159885 NP_082303 NP_001345486 NP_001345487

Location (UCSC)

Chr 12: 57.61 – 57.62 Mb

Chr 10: 127.02 – 127.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[5]

Interactions

GEFT has been shown to interact with RHOA.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000240771 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019467 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GEFT RAC/CDC42 exchange factor".
^ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs". Science. 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806. S2CID 2418867.
Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360. S2CID 11130365.
Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529.
Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.
Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere". J. Cell Sci. 115 (Pt 3): 629–40. doi:10.1242/jcs.115.3.629. PMID 11861769.

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This page was last edited on 9 March 2024, at 21:39

GEFT

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