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Formula | C24H28N8O2 |
Molar mass | 460.542 g·mol−1 |
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Gusacitinib (ASN002) is an investigational drug which acts as a pan-Janus kinase inhibitor, binding with similar affinity at JAK1, JAK2, JAK3 and TYK2, and also inhibiting spleen tyrosine kinase (SYK).[1] It is taken orally and was developed for the treatment of eczema and dermatitis.[2][3][4]
See also
References
- ^ Raghuvanshi R, Bharate SB (January 2022). "Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections". Journal of Medicinal Chemistry. 65 (2): 893–921. doi:10.1021/acs.jmedchem.0c01467. PMID 33539089.
- ^ Bissonnette R, Maari C, Forman S, Bhatia N, Lee M, Fowler J, et al. (October 2019). "The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: results from a randomized double-blind placebo-controlled study". The British Journal of Dermatology. 181 (4): 733–742. doi:10.1111/bjd.17932. PMC 6850605. PMID 30919407.
- ^ Zalewski A, Szepietowski JC (April 2023). "Topical and systemic JAK inhibitors in hand eczema - a narrative review". Expert Review of Clinical Immunology. 19 (4): 365–373. doi:10.1080/1744666X.2023.2174526. PMID 36708316.
- ^ Jimenez PA, Sofen HL, Bissonnette R, Lee M, Fowler J, Zammit DJ, et al. (August 2023). "Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study". Journal of the American Academy of Dermatology. 89 (2): 235–242. doi:10.1016/j.jaad.2023.04.027. PMID 37094653.
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