Svoboda | Graniru | BBC Russia | Golosameriki | Facebook

To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

How to transfigure the Wikipedia

Would you like Wikipedia to always look as professional and up-to-date? We have created a browser extension. It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology.

Try it — you can delete it anytime.

Install in 5 seconds
4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
Great Wikipedia has got greater.
.
Leo
Newton
Brights
Milds

Gusacitinib

From Wikipedia, the free encyclopedia

Gusacitinib
Identifiers
  • 2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC24H28N8O2
Molar mass460.542 g·mol−1
3D model (JSmol)
  • C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
  • InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
  • Key:NLFLXLJXEIUQDL-UHFFFAOYSA-N

Gusacitinib (ASN002) is an investigational drug which acts as a pan-Janus kinase inhibitor, binding with similar affinity at JAK1, JAK2, JAK3 and TYK2, and also inhibiting spleen tyrosine kinase (SYK).[1] It is taken orally and was developed for the treatment of eczema and dermatitis.[2][3][4]

See also

References

  1. ^ Raghuvanshi R, Bharate SB (January 2022). "Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections". Journal of Medicinal Chemistry. 65 (2): 893–921. doi:10.1021/acs.jmedchem.0c01467. PMID 33539089.
  2. ^ Bissonnette R, Maari C, Forman S, Bhatia N, Lee M, Fowler J, et al. (October 2019). "The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: results from a randomized double-blind placebo-controlled study". The British Journal of Dermatology. 181 (4): 733–742. doi:10.1111/bjd.17932. PMC 6850605. PMID 30919407.
  3. ^ Zalewski A, Szepietowski JC (April 2023). "Topical and systemic JAK inhibitors in hand eczema - a narrative review". Expert Review of Clinical Immunology. 19 (4): 365–373. doi:10.1080/1744666X.2023.2174526. PMID 36708316.
  4. ^ Jimenez PA, Sofen HL, Bissonnette R, Lee M, Fowler J, Zammit DJ, et al. (August 2023). "Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study". Journal of the American Academy of Dermatology. 89 (2): 235–242. doi:10.1016/j.jaad.2023.04.027. PMID 37094653.
Stub icon

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

This page was last edited on 22 June 2024, at 20:24
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.
Contact WIKI 2
Introduction
Terms of Service
Privacy Policy