Hesse-Kassel may refer to:
- German states with Kassel as the capital:
- Landgraviate of Hesse-Kassel (1567–1803)
- Electorate of Hesse (1803–1807, 1814–1866)
- Kassel (region)
- Province of Kurhessen
- KSV Hessen Kassel
- Hessen Cassel, Indiana, a community in the United States
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