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ILKAP

Identifiers

ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD

External IDs

MGI: 1914694; HomoloGene: 31525; GeneCards: ILKAP; OMA:ILKAP - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q37.3	Start	238,170,402 bp^[1]
Band	2q37.3	End	238,203,708 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 D	Start	91,373,861 bp^[2]
Band	1\|1 D	End	91,398,815 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar hemisphere

gastric mucosa

anterior pituitary

right lobe of thyroid gland

left lobe of thyroid gland

tibial nerve

sural nerve

canal of the cervix

skin of abdomen

left uterine tube

Top expressed in

neural tube

thymus

abdominal wall

superior frontal gyrus

ganglionic eminence

cerebellar cortex

adrenal gland

maxillary prominence

yolk sac

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein serine/threonine phosphatase activity protein binding catalytic activity phosphoprotein phosphatase activity hydrolase activity metal ion binding cation binding
Cellular component	cytoplasm nucleus nucleoplasm cytosol
Biological process	protein dephosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


80895


67444

Ensembl


ENSG00000132323


ENSMUSG00000026309

UniProt


Q9H0C8


Q8R0F6

RefSeq (mRNA)


NM_030768 NM_176799


NM_023343 NM_001355152

RefSeq (protein)


NP_110395


NP_075832 NP_001342081

Location (UCSC)

Chr 2: 238.17 – 238.2 Mb

Chr 1: 91.37 – 91.4 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.^[5]

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.^[5]

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132323 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
^ Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.

Tong Y, Quirion R, Shen SH (December 1998). "Cloning and characterization of a novel mammalian PP2C isozyme". The Journal of Biological Chemistry. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE (April 2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 3 March 2023, at 21:07

ILKAP

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Interactions

References

Further reading