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CEMIP

Identifiers

CEMIP, CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1

External IDs

OMIM: 608366; MGI: 2443629; HomoloGene: 10268; GeneCards: CEMIP; OMA:CEMIP - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q25.1	Start	80,779,343 bp^[1]
Band	15q25.1	End	80,951,776 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 D3\|7 48.35 cM	Start	83,582,065 bp^[2]
Band	7 D3\|7 48.35 cM	End	83,735,710 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trigeminal ganglion

stromal cell of endometrium

tibia

pericardium

olfactory bulb

lymph node

right lobe of thyroid gland

left lobe of thyroid gland

upper lobe of left lung

visceral pleura

Top expressed in

calvaria

body of femur

stria vascularis

trigeminal ganglion

spermatid

endocardial cushion

cochlea

visual cortex

atrioventricular valve

intercostal muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	clathrin heavy chain binding ER retention sequence binding hydrolase activity, acting on glycosyl bonds protein binding hyaluronic acid binding hydrolase activity hyalurononglucosaminidase activity
Cellular component	cytoplasm membrane plasma membrane extracellular region endoplasmic reticulum clathrin-coated pit nucleus clathrin-coated vesicle membrane clathrin-coated endocytic vesicle
Biological process	hyaluronan biosynthetic process hyaluronan catabolic process positive regulation of cell migration positive regulation of protein kinase C activity positive regulation of release of sequestered calcium ion into cytosol hearing positive regulation of peptidyl-threonine phosphorylation metabolism positive regulation of protein targeting to membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57214


80982

Ensembl


ENSG00000103888


ENSMUSG00000052353

UniProt


Q8WUJ3


Q8BI06

RefSeq (mRNA)


NM_018689 NM_001293298 NM_001293304


NM_030728

RefSeq (protein)


NP_001280227 NP_001280233 NP_061159


NP_109653

Location (UCSC)

Chr 15: 80.78 – 80.95 Mb

Chr 7: 83.58 – 83.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene.^[5] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases.^[6] Such function has also been validated in mice.^[7]

CEMIP is associated with nonsyndromic deafness,^[8] as well as a variety of cancers.^[9]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103888 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052353 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KIAA1199 KIAA1199".
^ Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, Sakai S, Sugiyama Y, Enomoto H, Okada Y, Inoue S (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences. 110 (14): 5612–5617. Bibcode:2013PNAS..110.5612Y. doi:10.1073/pnas.1215432110. PMC 3619336. PMID 23509262.
^ Yoshida H, Nagaoka A, Nakamura S, Sugiyama Y, Okada Y, Inoue S (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio. 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. PMC 3821019. PMID 24251095.
^ Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". J Hum Genet. 48 (11): 564–70. doi:10.1007/s10038-003-0079-2. PMID 14577002.
^ Zhang Y, Jia S, Jiang W (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports. 31 (4): 1503–1508. doi:10.3892/or.2014.3038. PMID 24573670.

Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Wines ME, Lee L, Katari MS, et al. (2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Abe S, Katagiri T, Saito-Hisaminato A, et al. (2003). "Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues". Am. J. Hum. Genet. 72 (1): 73–82. doi:10.1086/345398. PMC 420014. PMID 12471561.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Lett. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMID 16406369. S2CID 1013478.

v <abbr title="Discuss this template">t</abbr> e KIAA human genes
KIAA0020 KIAA0101 KIAA0157 KIAA0174 KIAA0182 KIAA0196 KIAA0243 KIAA0274 KIAA0319 KIAA0368 KIAA0409 KIAA0430 KIAA0460 KIAA0515 KIAA0802 KIAA0859 KIAA0895 KIAA0999 KIAA1012 KIAA1109 KIAA1166 KIAA1199 KIAA1219 KIAA1267 KIAA1279 KIAA1303 KIAA1333 KIAA1377 KIAA1524 KIAA1539 KIAA1683 KIAA1826 KIAA1949 KIAA1967

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This page was last edited on 2 June 2024, at 10:14

CEMIP

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