BBC Russian

LORICRIN

Identifiers

LORICRIN, loricrin, LOR, loricrin cornified envelope precursor protein

External IDs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	153,259,687 bp^[1]
Band	1q21.3	End	153,262,124 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nipple

vulva

human penis

skin of abdomen

gums

amniotic fluid

gastrocnemius muscle

hair follicle

cingulate gyrus

left ventricle

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein-macromolecule adaptor activity structural constituent of cytoskeleton protein binding structural molecule activity structural constituent of skin epidermis
Cellular component	cytoplasm nucleoplasm nucleus cornified envelope cytosol
Biological process	peptide cross-linking keratinization keratinocyte differentiation cytoskeleton organization cornification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4014


n/a

Ensembl


ENSG00000203782


n/a

UniProt


P23490


n/a

RefSeq (mRNA)


NM_000427


n/a

RefSeq (protein)


NP_000418


n/a

Location (UCSC)

Chr 1: 153.26 – 153.26 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Loricrin is a protein that in humans is encoded by the LOR gene.^[3]^[4]^[5]

YouTube Encyclopedic

1/1
Views:
25 261

Transcription

Function

Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells.^[5]

Loricrin is expressed in the granular layer of all keratinized epithelial cells of mammals tested including oral, esophageal and stomach mucosa of rodents, tracheal squamous metaplasia of vitamin A deficient hamster and estrogen induced squamous vaginal epithelium of rats.^[6]

Clinical significance

Mutations in the LOR gene are associated with Vohwinkel's syndrome and Camisa disease, both inherited skin diseases.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000203782 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hohl D, Mehrel T, Lichti U, Turner ML, Roop DR, Steinert PM (May 1991). "Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins". J Biol Chem. 266 (10): 6626–36. doi:10.1016/S0021-9258(18)38163-8. PMID 2007607.
^ Yoneda K, Hohl D, McBride OW, Wang M, Cehrs KU, Idler WW, Steinert PM (Oct 1992). "The human loricrin gene". J Biol Chem. 267 (25): 18060–6. doi:10.1016/S0021-9258(19)37152-2. PMID 1355480.
^ ^a ^b "Entrez Gene: LOR loricrin".
^ Hohl D, Ruf Olano B, de Viragh PA, Huber M, Detrisac CJ, Schnyder UW, Roop DR (1993). "Expression patterns of loricrin in various species and tissues". Differentiation. 54 (1): 25–34. doi:10.1111/j.1432-0436.1993.tb01585.x. PMID 8405772.

Ishida-Yamamoto A, Takahashi H, Iizuka H (1998). "Loricrin and human skin diseases: molecular basis of loricrin keratodermas". Histol. Histopathol. 13 (3): 819–26. PMID 9690138.
Ishida-Yamamoto A (2003). "Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin". J. Dermatol. Sci. 31 (1): 3–8. doi:10.1016/S0923-1811(02)00143-3. PMID 12615358.
Candi E, Melino G, Mei G, et al. (1995). "Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein" (PDF). J. Biol. Chem. 270 (44): 26382–90. doi:10.1074/jbc.270.44.26382. PMID 7592852.
Yoneda K, Steinert PM (1993). "Overexpression of human loricrin in transgenic mice produces a normal phenotype". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10754–8. Bibcode:1993PNAS...9010754Y. doi:10.1073/pnas.90.22.10754. PMC 47856. PMID 8248167.
Ishida-Yamamoto A, Hohl D, Roop DR, et al. (1994). "Loricrin immunoreactivity in human skin: localization to specific granules (L-granules) in acrosyringia". Arch. Dermatol. Res. 285 (8): 491–8. doi:10.1007/BF00376822. PMID 8274037. S2CID 9857068.
Maestrini E, Monaco AP, McGrath JA, et al. (1996). "A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome". Nat. Genet. 13 (1): 70–7. doi:10.1038/ng0596-70. PMID 8673107. S2CID 9108586.
Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. doi:10.1074/jbc.272.3.2021. PMID 8999895.
Ishida-Yamamoto A, McGrath JA, Lam H, et al. (1997). "The molecular pathology of progressive symmetric erythrokeratoderma: a frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope". Am. J. Hum. Genet. 61 (3): 581–9. doi:10.1086/515518. PMC 1715943. PMID 9326323.
Korge BP, Ishida-Yamamoto A, Pünter C, et al. (1997). "Loricrin mutation in Vohwinkel's keratoderma is unique to the variant with ichthyosis". J. Invest. Dermatol. 109 (4): 604–10. doi:10.1111/1523-1747.ep12337534. PMID 9326398.
Candi E, Tarcsa E, Idler WW, et al. (1999). "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin". J. Biol. Chem. 274 (11): 7226–37. doi:10.1074/jbc.274.11.7226. PMID 10066784.
Richard G, Brown N, Smith LE, et al. (2000). "The spectrum of mutations in erythrokeratodermias--novel and de novo mutations in GJB3". Hum. Genet. 106 (3): 321–9. doi:10.1007/s004390051045 (inactive 2024-02-22). PMID 10798362.{{cite journal}}: CS1 maint: DOI inactive as of February 2024 (link)
Lee CH, Marekov LN, Kim S, et al. (2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Lett. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733. S2CID 12228606.
Candi E, Oddi S, Terrinoni A, et al. (2001). "Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro". J. Biol. Chem. 276 (37): 35014–23. doi:10.1074/jbc.M010157200. PMID 11443109.
Matsumoto K, Muto M, Seki S, et al. (2001). "Loricrin keratoderma: a cause of congenital ichthyosiform erythroderma and collodion baby". Br. J. Dermatol. 145 (4): 657–60. doi:10.1046/j.1365-2133.2001.04412.x. PMID 11703298. S2CID 32827034.
O'Driscoll J, Muston GC, McGrath JA, et al. (2002). "A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome". Clin. Exp. Dermatol. 27 (3): 243–6. doi:10.1046/j.1365-2230.2002.01031.x. PMID 12072018. S2CID 44453747.
Jang SI, Steinert PM (2003). "Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 families". J. Biol. Chem. 277 (44): 42268–79. doi:10.1074/jbc.M205593200. PMID 12200429.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 22 February 2024, at 07:09

Loricrin

From Wikipedia, the free encyclopedia

YouTube Encyclopedic

Transcription

Function

Clinical significance

See also

References

Further reading