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Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1gene.[5][6][7]
Function
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abShiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID9647739.
^Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. doi:10.1007/s004390050476. PMID9225980. S2CID25999127.
^Dobrosotskaya IY, James GL (Apr 2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures". Biochemical and Biophysical Research Communications. 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. PMID10772923.
^Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (Nov 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID14627983. S2CID6289557.
Dobrosotskaya IY, James GL (Apr 2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures". Biochemical and Biophysical Research Communications. 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. PMID10772923.
Dobrosotskaya IY (May 2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1". Biochemical and Biophysical Research Communications. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID11350080.
Laura RP, Ross S, Koeppen H, Lasky LA (May 2002). "MAGI-1: a widely expressed, alternatively spliced tight junction protein". Experimental Cell Research. 275 (2): 155–70. doi:10.1006/excr.2002.5475. PMID11969287.
Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (Nov 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID14627983. S2CID6289557.
Patrie KM (Aug 2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID16019084.