BBC Russian

MEX3D

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DGR

Identifiers

Aliases

MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D

External IDs

OMIM: 611009; MGI: 2681847; HomoloGene: 16890; GeneCards: MEX3D; OMA:MEX3D - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	1,554,672 bp^[1]
Band	19p13.3	End	1,568,325 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 C1	Start	80,216,189 bp^[2]
Band	10\|10 C1	End	80,223,493 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

secondary oocyte

stromal cell of endometrium

sural nerve

skin of abdomen

right lung

canal of the cervix

left uterine tube

ascending aorta

minor salivary glands

Top expressed in

seminiferous tubule

hand

medial ganglionic eminence

maxillary prominence

superior cervical ganglion

spermatid

endocardial cushion

atrium

renal corpuscle

abdominal wall

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	metal ion binding nucleic acid binding RNA binding mRNA 3'-UTR AU-rich region binding
Cellular component	cytoplasm perinuclear region of cytoplasm nucleus
Biological process	mRNA destabilization mRNA localization resulting in posttranscriptional regulation of gene expression
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


399664


237400

Ensembl


ENSG00000181588


ENSMUSG00000048696

UniProt


Q86XN8


Q3UE17

RefSeq (mRNA)


NM_001174118 NM_203304


NM_198615

RefSeq (protein)


NP_001167589 NP_976049


NP_941017

Location (UCSC)

Chr 19: 1.55 – 1.57 Mb

Chr 10: 80.22 – 80.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.^[5]^[6]

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.^[6]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048696 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: mex-3 homolog D (C. elegans)".
^ ^a ^b ^c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 17 April 2022, at 01:39

MEX3D

From Wikipedia, the free encyclopedia

Function

Structure

References

Further reading