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MORC3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4QQ4

Identifiers

Aliases

MORC3, NXP2, ZCW5, ZCWCC3, MORC family CW-type zinc finger 3

External IDs

OMIM: 610078 MGI: 2136841 HomoloGene: 32257 GeneCards: MORC3

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q22.12	Start	36,320,189 bp^[1]
Band	21q22.12	End	36,386,148 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C4	Start	93,629,009 bp^[2]
Band	16\|16 C4	End	93,672,961 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

middle frontal gyrus

Brodmann area 10

frontal pole

palpebral conjunctiva

tibia

monocyte

thymus

vagina

amniotic fluid

Top expressed in

spermatocyte

primitive streak

lymph node

otic placode

conjunctival fornix

saccule

iris

left lung lobe

superior cervical ganglion

Paneth cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	zinc ion binding metal ion binding RNA binding protein binding
Cellular component	nuclear matrix PML body nucleus nucleoplasm
Biological process	protein phosphorylation protein stabilization viral process negative regulation of fibroblast proliferation post-embryonic development peptidyl-serine phosphorylation maintenance of protein location in nucleus
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23515


338467

Ensembl


ENSG00000159256


ENSMUSG00000039456

UniProt


Q14149


F7BJB9

RefSeq (mRNA)


NM_015358 NM_001320445 NM_001320446


NM_001045529

RefSeq (protein)


NP_001307374 NP_001307375 NP_056173


NP_001038994

Location (UCSC)

Chr 21: 36.32 – 36.39 Mb

Chr 16: 93.63 – 93.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.^[5]^[6]

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.^[6]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039456 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.
^ ^a ^b "Entrez Gene: MORC3 MORC family CW-type zinc finger 3".

Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Kimura Y, Sakai F, Nakano O, et al. (2002). "The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains". J. Biol. Chem. 277 (23): 20611–7. doi:10.1074/jbc.M201440200. PMID 11927593.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rosendorff A, Sakakibara S, Lu S, et al. (2006). "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5308–13. Bibcode:2006PNAS..103.5308R. doi:10.1073/pnas.0601066103. PMC 1459351. PMID 16567619.
Takahashi K, Yoshida N, Murakami N, et al. (2007). "Dynamic regulation of p53 subnuclear localization and senescence by MORC3". Mol. Biol. Cell. 18 (5): 1701–9. doi:10.1091/mbc.E06-08-0747. PMC 1855011. PMID 17332504.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 14 October 2023, at 20:43

MORC3

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See also

References

Further reading