Michelle Chia-yu Chang | |
|---|---|
| Born | 1977 (age 46–47) San Diego, California, U.S. |
| Alma mater | University of California, San Diego B.S. (1997) Massachusetts Institute of Technology Ph.D. (2004) |
| Spouse | Christopher Chang |
| Scientific career | |
| Fields | Metabolic engineering, Synthetic biology |
| Institutions | UC Berkeley |
| Thesis | Proton-coupled electron transfer in the Escherichia coli ribonucleotide reductase (2004) |
| Doctoral advisor | JoAnne Stubbe and Daniel G. Nocera |
| Other academic advisors | Jay Keasling |
| Website | www |
Michelle C. Y. Chang (born 1977) is a Professor of Chemistry and Chemical and Biomolecular Engineering at the University of California, Berkeley, and is a recipient of several young scientist awards for her research in biosynthesis of biofuels and pharmaceuticals.[1]
Education
Chang received her B.S. in Biochemistry and B.A. in French Literature from the University of California, San Diego in 1997.
She then moved to the Massachusetts Institute of Technology for graduate school as a National Science Foundation Predoctoral Fellow (1997-2000) and M.I.T./Merck Foundation Predoctoral Fellow (2000-2002). She earned her Ph.D. in 2004 under the direction of JoAnne Stubbe and Daniel G. Nocera. During her graduate work, Chang studied proton-coupled electron transfer processes in ribonucleotide reductase enzymes, and demonstrated the first direct evidence of the radical transfer pathway of class I RNRs.[2][3][4]
Following graduate school, she conducted research as a Jane Coffin Childs Memorial Fund for Medical Research Postdoctoral Fellow at University of California, Berkeley with Jay Keasling (2004-2007). At Berkeley, Chang studied enzyme-catalyzed reactions, demonstrating that by expressing plant P450 enzymes in bacteria like E. coli, the E. coli could be engineered to produce terpenoids, a class of natural products often found in drugs.[5][6] Chang began her independent career at UC Berkeley in 2007.
Awards
- 2007: The Camille and Henry Dreyfus Foundation New Faculty Award [1]
- 2008: Arnold and Mabel Beckman Foundation Young Investigator Award[1]
- 2008: TR35: Technology Review magazine Young Innovator Award[7]
- 2009: National Science Foundation Faculty Early Career Development (CAREER) award[8]
- 2010: Agilent Early Career Professor Award[9]
- 2011: International Young Talents in Chemistry Award[10]
- 2011: NIH Director's New Innovator Award[11]
- 2012: Agnes Fay Morgan Research Award[12]
- 2015: Arthur C. Cope Scholar Award[13]
- 2016: Pfizer Award in Enzyme Chemistry
Personal life
Michelle was born in San Diego, California, to Chinese immigrant parents from Taiwan.[14] She is married to her colleague in the College of Chemistry, Christopher Chang.[15]
Publications
Chang's scientific papers are listed on her group's website.
References
- ^ a b c "Faculty & Research - College of Chemistry". chem.berkeley.edu.
- ^ Chang, Michelle C. Y. (Michelle Chia-yu) (2004). Proton-coupled electron transfer in the Escherichia coli ribonucleotide reductase (Thesis). Massachusetts Institute of Technology. hdl:1721.1/30067.
- ^ Chang, Michelle C. Y.; Yee, Cyril S.; Stubbe, JoAnne; Nocera, Daniel G. (2004-05-04). "Turning on ribonucleotide reductase by light-initiated amino acid radical generation". Proceedings of the National Academy of Sciences. 101 (18): 6882–6887. Bibcode:2004PNAS..101.6882C. doi:10.1073/pnas.0401718101. ISSN 0027-8424. PMC 406436. PMID 15123822.
- ^ Chang, Michelle C. Y.; Yee, Cyril S.; Nocera, Daniel G.; Stubbe, JoAnne (2004-12-01). "Site-Specific Replacement of a Conserved Tyrosine in Ribonucleotide Reductase with an Aniline Amino Acid: A Mechanistic Probe for a Redox-Active Tyrosine". Journal of the American Chemical Society. 126 (51): 16702–16703. doi:10.1021/ja044124d. ISSN 0002-7863. PMID 15612690.
- ^ "Michelle Chang: A catalyst for change". The Scientist Magazine®. Retrieved 2021-05-15.
- ^ Chang, Michelle C. Y.; Eachus, Rachel A.; Trieu, William; Ro, Dae-Kyun; Keasling, Jay D. (2007). "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s". Nature Chemical Biology. 3 (5): 274–277. doi:10.1038/nchembio875. ISSN 1552-4469. PMID 17438551.
- ^ Review, MIT Technology. "Innovator Under 35: Michelle Chang, 31". MIT Technology Review.
- ^ CAREER award Archived 2011-09-28 at the Wayback Machine
- ^ Agilent Early Career Award Archived 2011-09-28 at the Wayback Machine
- ^ International Young Talents Archived 2011-09-28 at the Wayback Machine
- ^ "UC Berkeley, College of Chemistry - News and Publications - Chang and Hammond win NIH New Innovator Awards". Archived from the original on 2011-12-09. Retrieved 2011-10-20.
- ^ "2012 Agnes Fay Morgan Research Award, Dr Michelle Chang" (PDF). iotasigmapi.info.
- ^ "2015 National Award Recipients". American Chemical Society. Retrieved 2016-03-20.
- ^ "財經新聞 - PChome 新聞". PChome 新聞.
- ^ "National magazines tout two chemists and two astronomers as top innovators in their fields" Archived 2011-06-13 at the Wayback Machine, UC Newsroom, August 22, 2008 (retrieved January 26, 2010)
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This page was last edited on 7 April 2024, at 04:04