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NINL

Identifiers

NINL, NLP, dJ691N24.1, ninein like

External IDs

OMIM: 609580 MGI: 1925427 HomoloGene: 57024 GeneCards: NINL

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20p11.21	Start	25,452,697 bp^[1]
Band	20p11.21	End	25,585,531 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 G3	Start	150,776,439 bp^[2]
Band	2\|2 G3	End	150,881,302 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal medulla

cerebellar hemisphere

ganglionic eminence

kidney

right lobe of thyroid gland

pituitary gland

left lobe of thyroid gland

tibia

right lobe of liver

anterior pituitary

Top expressed in

superior cervical ganglion

spermatocyte

olfactory epithelium

spermatid

abdominal wall

hand

testicle

cumulus cell

ovary

primitive streak

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding protein binding metal ion binding
Cellular component	cytoplasm microtubule microtubule organizing center cytosol intercellular bridge cytoskeleton centrosome
Biological process	G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule anchoring at centrosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22981


78177

Ensembl


ENSG00000101004


ENSMUSG00000068115

UniProt


Q9Y2I6


Q6ZQ12

RefSeq (mRNA)


NM_025176 NM_001318226


NM_207204

RefSeq (protein)


NP_001305155 NP_079452


NP_997087

Location (UCSC)

Chr 20: 25.45 – 25.59 Mb

Chr 2: 150.78 – 150.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ninein-like protein is a protein that in humans is encoded by the NINL gene.^[5]^[6] It is part of the centrosome.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101004 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068115 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ "Entrez Gene: RP4-691N24.1 KIAA0980 protein".
^ Casenghi, Martina (2003). Functional characterization of the novel centrosomal protein Nlp (ninein-like protein) (PDF) (Ph.D thesis).

Wang Y, Zhan Q (2007). "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex". J. Biol. Chem. 282 (24): 17712–9. doi:10.1074/jbc.M701350200. PMID 17403670.
Casenghi M, Barr FA, Nigg EA (2005). "Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome". J. Cell Sci. 118 (Pt 21): 5101–8. doi:10.1242/jcs.02622. PMID 16254247. S2CID 23146359.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 18 December 2023, at 06:27

Ninein-like protein

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References

Further reading