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NUDCD3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WGV

Identifiers

Aliases

NUDCD3, NudCL, NudC domain containing 3

External IDs

OMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7p13	Start	44,379,119 bp^[1]
Band	7p13	End	44,490,658 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 A1	Start	6,055,691 bp^[2]
Band	11\|11 A1	End	6,150,415 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

Brodmann area 9

cerebellar hemisphere

gastrocnemius muscle

stromal cell of endometrium

nucleus accumbens

islet of Langerhans

sural nerve

popliteal artery

putamen

Top expressed in

superior frontal gyrus

dorsomedial hypothalamic nucleus

cerebellar cortex

piriform cortex

temporal muscle

subiculum

triceps brachii muscle

cerebellar vermis

habenula

olfactory tubercle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding unfolded protein binding
Cellular component	cytoplasm cytoplasmic dynein complex
Biological process	protein folding cilium assembly protein localization to pericentriolar material developmental process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23386


209586

Ensembl


ENSG00000015676


ENSMUSG00000053838

UniProt


Q8IVD9


Q8R1N4

RefSeq (mRNA)


NM_015332


NM_173748 NM_001363446

RefSeq (protein)


NP_056147


NP_776109 NP_001350375

Location (UCSC)

Chr 7: 44.38 – 44.49 Mb

Chr 11: 6.06 – 6.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.^[5]

Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000015676 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NUDCD3 NudC domain containing 3".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9039–44. Bibcode:2006PNAS..103.9039Z. doi:10.1073/pnas.0602916103. PMC 1482562. PMID 16754861.

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1wgv: Solution Structure of the CS Domain of Human KIAA1068 Protein

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This page was last edited on 29 May 2024, at 17:23

NUDCD3

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Function

References

Further reading