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Naltriben

From Wikipedia, the free encyclopedia

Naltriben
Skeletal formula
Ball-and-stick model of naltriben
Clinical data
ATC code
  • none
Identifiers
CAS Number
Chemical and physical data
FormulaC26H25NO4
Molar mass415.489 g·mol−1
3D model (JSmol)
  • Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7
  • InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 checkY
  • Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N checkY
  (verify)

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]

See also

References

  1. ^ Sofuoglu M, Portoghese PS, Takemori AE (May 1991). "Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes". The Journal of Pharmacology and Experimental Therapeutics. 257 (2): 676–80. PMID 1851833.
  2. ^ Stewart PE, Holper EM, Hammond DL (1994). "Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes". Life Sciences. 55 (4): PL79-84. doi:10.1016/0024-3205(94)00738-1. PMID 8028443.
This page was last edited on 27 September 2023, at 09:15
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