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Oxyclozanide

From Wikipedia, the free encyclopedia

Oxyclozanide
Names
Preferred IUPAC name
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.017.186 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22) ☒N
    Key: JYWIYHUXVMAGLG-UHFFFAOYSA-N ☒N
  • InChI=1/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)
    Key: JYWIYHUXVMAGLG-UHFFFAOYAW
  • C1=C(C=C(C(=C1Cl)O)NC(=O)C2=C(C(=CC(=C2Cl)Cl)Cl)O)Cl
Properties
C13H6Cl5NO3
Molar mass 401.45 g·mol−1
Pharmacology
QP52AG06 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.[1] Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".[2]

Sometimes alluded to as "Pentaclosamide": CN101891646.

References

[3]

  1. ^ CID 16779 from PubChem
  2. ^ Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Conery, Annie L.; Kim, Wooseong; Jayamani, Elamparithi; Kwon, Bumsup; Ausubel, Frederick M.; Mylonakis, Eleftherios (2015). "Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus". PLOS ONE. 10 (4): e0124595. Bibcode:2015PLoSO..1024595R. doi:10.1371/journal.pone.0124595. PMC 4405337. PMID 25897961.
  3. ^ Oxyclozanide MSDS


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This page was last edited on 12 January 2023, at 08:11
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