BBC Russian

PIGF

Identifiers

PIGF, phosphatidylinositol glycan anchor biosynthesis class F, OORS

External IDs

OMIM: 600153; MGI: 99462; HomoloGene: 31103; GeneCards: PIGF; OMA:PIGF - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p21	Start	46,580,937 bp^[1]
Band	2p21	End	46,617,055 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 E4\|17 56.9 cM	Start	87,304,684 bp^[2]
Band	17 E4\|17 56.9 cM	End	87,332,834 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

islet of Langerhans

right adrenal gland

rectum

left adrenal gland

monocyte

stromal cell of endometrium

body of pancreas

Achilles tendon

gallbladder

Top expressed in

spermatid

secondary oocyte

spermatocyte

seminiferous tubule

Paneth cell

epithelium of stomach

primitive streak

yolk sac

pyloric antrum

condyle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ethanolaminephosphotransferase activity
Cellular component	integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane
Biological process	GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5281


18701

Ensembl


ENSG00000151665


ENSMUSG00000024145

UniProt


Q07326


O09101

RefSeq (mRNA)


NM_002643 NM_173074


NM_008838

RefSeq (protein)


NP_002634 NP_775097


NP_032864

Location (UCSC)

Chr 2: 46.58 – 46.62 Mb

Chr 17: 87.3 – 87.33 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.^[5]^[6]^[7]

Function

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151665 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024145 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Oct 1995). "Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF". Genomics. 29 (3): 804–807. doi:10.1006/geno.1995.9929. PMID 8575782.
^ Inoue N, Kinoshita T, Orii T, Takeda J (Apr 1993). "Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy". The Journal of Biological Chemistry. 268 (10): 6882–6885. doi:10.1016/S0021-9258(18)53122-7. PMID 8463218.
^ ^a ^b "Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F".

Kinoshita T, Takahashi M, Inoue N, Miyata T, Takeda J (Feb 1994). "Expression cloning of genes for GPI-anchor biosynthesis". Brazilian Journal of Medical and Biological Research. 27 (2): 127–132. PMID 8081220.
Hong Y, Maeda Y, Watanabe R, Inoue N, Ohishi K, Kinoshita T (Jul 2000). "Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol". The Journal of Biological Chemistry. 275 (27): 20911–20919. doi:10.1074/jbc.M001913200. PMID 10781593.
Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y, Kinoshita T (Mar 2005). "GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol". The Journal of Biological Chemistry. 280 (10): 9728–9734. doi:10.1074/jbc.M413755200. PMID 15632136.
Li W, Shen W, Gill R, Corbly A, Jones B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K, Westmore M, Hanson J, Chen YF, Simons M, Singh J (May 2006). "High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb". Circulation. 113 (20): 2445–2453. doi:10.1161/CIRCULATIONAHA.105.586818. PMID 16702473.
Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC (Jun 2006). "Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality" (PDF). The Journal of Experimental Medicine. 203 (6): 1447–1458. doi:10.1084/jem.20060375. PMC 2118329. PMID 16702604.
Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M (Sep 2006). "Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation". Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (9): 2019–2026. doi:10.1161/01.ATV.0000233336.53574.a1. PMID 16794222.
Mohammed KA, Nasreen N, Tepper RS, Antony VB (Feb 2007). "Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release". American Journal of Physiology. Lung Cellular and Molecular Physiology. 292 (2): L559–566. doi:10.1152/ajplung.00075.2006. PMID 17028267.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 7 January 2024, at 06:46

PIGF

From Wikipedia, the free encyclopedia

Function

See also

References

Further reading