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DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3Kgene.[5][6][7]
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes.
The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription.[7]
^Spakovskii GV, Lebedenko EN (Mar 1999). "[Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III]". Bioorg Khim. 24 (11): 877–80. PMID10079944.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID1403646.
Flint J, Thomas K, Micklem G, et al. (1997). "The relationship between chromosome structure and function at a human telomeric region". Nat. Genet. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID9054936. S2CID20630444.
This page was last edited on 28 October 2022, at 16:00