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RAB22A

Identifiers

RAB22A, member RAS oncogene family

External IDs

OMIM: 612966 MGI: 105072 HomoloGene: 10782 GeneCards: RAB22A

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.32	Start	58,309,715 bp^[1]
Band	20q13.32	End	58,367,507 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 H4\|2 97.26 cM	Start	173,501,553 bp^[2]
Band	2 H4\|2 97.26 cM	End	173,549,136 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

frontal pole

Brodmann area 10

Brodmann area 23

Brodmann area 46

middle frontal gyrus

oocyte

secondary oocyte

orbitofrontal cortex

postcentral gyrus

Top expressed in

interventricular septum

aortic valve

ascending aorta

cumulus cell

right ventricle

internal carotid artery

temporal muscle

saccule

triceps brachii muscle

spermatid

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GDP binding GTP binding protein binding GTPase activity
Cellular component	endosome late endosome phagocytic vesicle membrane cell projection membrane ruffle plasma membrane early endosome phagocytic vesicle actin cytoskeleton endosome membrane extracellular exosome cytoplasmic vesicle
Biological process	endosome organization regulation of vesicle size protein transport transport endocytosis intracellular protein transport Rab protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57403


19334

Ensembl


ENSG00000124209


ENSMUSG00000027519

UniProt


Q9UL26


P35285

RefSeq (mRNA)


NM_020673


NM_024436

RefSeq (protein)


NP_065724


NP_077756

Location (UCSC)

Chr 20: 58.31 – 58.37 Mb

Chr 2: 173.5 – 173.55 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.^[5]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124209 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027519 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni C (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Opdam FJ, Kamps G, Croes H, Van Bokhoven H, Ginsel LA, Fransen JA (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–871. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, Olkkonen VM (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell Sci. 115 (Pt 5): 899–911. doi:10.1242/jcs.115.5.899. PMID 11870209.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi:10.1074/jbc.M311228200. PMID 14613930.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell. 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC 491835. PMID 15181155.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mesa R, Magadán J, Barbieri A, López C, Stahl PD, Mayorga LS (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Magadán JG, Barbieri MA, Mesa R, Stahl PD, Mayorga LS (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC 1430328. PMID 16537905.

v t e PDB gallery
1yvd: GppNHp-Bound Rab22 GTPase 1z0j: Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 27 January 2024, at 15:14

RAB22A

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References

Further reading