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RASD2

Identifiers

RASD2, MGC:4834, Rhes, TEM2, RASD family member 2

External IDs

OMIM: 612842 MGI: 1922391 HomoloGene: 8628 GeneCards: RASD2

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q12.3	Start	35,540,831 bp^[1]
Band	22q12.3	End	35,553,999 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 C1	Start	75,940,572 bp^[2]
Band	8\|8 C1	End	75,950,741 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

putamen

caudate nucleus

nucleus accumbens

prefrontal cortex

Brodmann area 9

cingulate gyrus

postcentral gyrus

external globus pallidus

amygdala

hypothalamus

Top expressed in

superior frontal gyrus

nucleus accumbens

visual cortex

olfactory tubercle

substantia nigra

gastrocnemius muscle

lacrimal gland

globus pallidus

motor neuron

parotid gland

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G-protein beta-subunit binding nucleotide binding GTP binding ubiquitin conjugating enzyme binding phosphatidylinositol 3-kinase binding GTPase activity
Cellular component	plasma membrane membrane
Biological process	negative regulation of protein ubiquitination regulation of cAMP-mediated signaling positive regulation of protein kinase B signaling synaptic transmission, dopaminergic positive regulation of protein sumoylation locomotory behavior signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23551


75141

Ensembl


ENSG00000100302


ENSMUSG00000034472

UniProt


Q96D21


P63032

RefSeq (mRNA)


NM_014310 NM_001366725 NM_001376515 NM_001376516


NM_029182

RefSeq (protein)


NP_055125 NP_001353654 NP_001363444 NP_001363445


NP_083458

Location (UCSC)

Chr 22: 35.54 – 35.55 Mb

Chr 8: 75.94 – 75.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.^[5]^[6]^[7]^[8]

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100302 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034472 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. doi:10.1126/science.289.5482.1197. PMID 10947988.
^ Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (Oct 1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res. 57 (6): 782–8. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249. S2CID 21124545.
^ Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584.
^ ^a ^b "Entrez Gene: RASD2 RASD family, member 2".

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Chan SL, Monks LK, Gao H, et al. (2002). "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic β-cell". Br. J. Pharmacol. 136 (1): 31–6. doi:10.1038/sj.bjp.0704680. PMC 1762110. PMID 11976265.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Taylor JP, Jackson DA, Morgan NG, Chan SL (2006). "Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process". Biochem. Biophys. Res. Commun. 349 (2): 809–15. doi:10.1016/j.bbrc.2006.08.102. PMID 16945334.
Agretti P, De Marco G, Pinchera A, et al. (2007). "Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells". J. Endocrinol. Invest. 30 (4): 279–84. doi:10.1007/bf03346294. PMID 17556863. S2CID 38877975.

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This page was last edited on 28 February 2024, at 09:32

RASD2

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Further reading