Retroposons are repetitive DNA fragments which are inserted into chromosomes after they had been reverse transcribed from any RNA molecule.
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Transposable elements
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The retroviral and retroviral-like transposon lifecycle
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RNA Transposons
Transcription
Difference between retroposons and retrotransposons
In contrast to retrotransposons, retroposons never encode reverse transcriptase (RT) (but see below). Therefore, they are non-autonomous elements with regard to transposition activity (as opposed to transposons). Non-long terminal repeat (LTR) retrotransposons such as the human LINE1 elements are sometimes falsely referred to as retroposons. However, this depends on the author. For example, Howard Temin published the following definition: Retroposons encode RT but are devoid of long terminal repeats (LTRs), for example long interspersed elements (LINEs). Retrotransposons also feature LTRs and retroviruses, in addition, are packaged as viral particles (virions). Retrosequences are non-autonomous elements devoid of RT. They are retroposed with the aid of the machinery of autonomous elements, such as LINEs; examples are short interspersed nuclear elements (SINEs) or mRNA-derived retro(pseudo)genes.[2][3][4]
Gene duplications
Retroposition accounts for approximately 10,000 gene-duplication events in the human genome, of which approximately 2-10% are likely to be functional.[5] Such genes are called retrogenes and represent a certain type of retroposon.
Horizontal gene transfer
A classical event is the retroposition of a spliced pre-mRNA molecule of the c-Src gene into the proviral ancestor of the Rous sarcoma virus (RSV). The retroposed c-src pre-mRNA still contained a single intron and within RSV is now referred to as v-Src gene.[6]
References
- ^ Nilsson, M. A.; Churakov, G.; Sommer, M.; et al. (2010). "Tracking Marsupial Evolution Using Archaic Genomic Retroposon Insertions". PLOS Biology. 8 (7): e1000436. doi:10.1371/journal.pbio.1000436. PMC 2910653. PMID 20668664.
- ^ Temin HM (1989). "Retrons in bacteria". Nature. 339 (6222): 254–5. Bibcode:1989Natur.339..254T. doi:10.1038/339254a0. PMID 2471077. S2CID 29368479.
- ^ Makałowski W, Toda Y (2007). "Modulation of Host Genes by Mammalian Transposable Elements". In Volff JN, Schmid M (eds.). Gene and Protein Evolution. Genome Dynamics. Vol. 3 (3rd ed.). Basel: S. Karger. p. 166. doi:10.1159/000107610. ISBN 978-3-8055-8341-1. OCLC 729848415. PMID 18753791.
- ^ Makałowski W, Gotea V, Pande A, Makałowska I (2019). "Transposable Elements: Classification, Identification, and Their Use as a Tool for Comparative Genomics". In Anisimova M (ed.). Evolutionary Genomics. Methods in Molecular Biology. Vol. 1910. Clifton, NJ. pp. 185–86. doi:10.1007/978-1-4939-9074-0_6. ISBN 978-3-8055-8341-1. OCLC 145014779. PMID 31278665.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ Emerson JJ, Kaessmann H, Betrán E, Long M (January 2004). "Extensive gene traffic on the mammalian X chromosome". Science. 303 (5657): 537–40. Bibcode:2004Sci...303..537E. doi:10.1126/science.1090042. PMID 14739461. S2CID 41158232.
- ^ Swanstrom, R; Parker, R C; Varmus, H E; Bishop, J M (May 1983). "Transduction of a cellular oncogene: the genesis of Rous sarcoma virus". Proceedings of the National Academy of Sciences. 80 (9): 2519–2523. Bibcode:1983PNAS...80.2519S. doi:10.1073/pnas.80.9.2519. PMC 393857. PMID 6302692.
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