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Kallistatin is a protein that in humans is encoded by the SERPINA4gene.[3][4]
Kallistatin consists of three folded ß segments and eight helical structures and contains two functional domains, an active site and a heparin-binding site.
Kallistatin signals through several receptors, including integrin ß3, lipoprotein receptor-related protein 6 ( LRP6 ), nucleolin, and Krüppel-like factor 4 ( KLF4 ).[5][6]
Wang MY, Day J, Chao L, Chao J (1989). "Human Kallistatin, a New Tissue Kallikrein-Binding Protein: Purification and Characterization". Kinins V. Advances in Experimental Medicine and Biology. Vol. 247B. pp. 1–8. doi:10.1007/978-1-4615-9546-5_1 (inactive 2024-04-03). ISBN978-1-4615-9548-9. PMID2558505.{{cite book}}: CS1 maint: DOI inactive as of April 2024 (link)
Chao J, Schmaier A, Chen LM, Yang Z, Chao L (1996). "Kallistatin, a novel human tissue kallikrein inhibitor: levels in body fluids, blood cells, and tissues in health and disease". J. Lab. Clin. Med. 127 (6): 612–620. doi:10.1016/S0022-2143(96)90152-3. PMID8648266.
Wang DZ, Song Q, Chen LM, Chao L, Chao J (1996). "Expression and cellular localization of tissue kallikrein-kinin system in human adrenal gland". Am. J. Physiol. 271 (3 Pt 2): F709–16. doi:10.1152/ajprenal.1996.271.3.F709. PMID8853434.
Ma JX, King LP, Yang Z, Crouch RK, Chao L, Chao J (1997). "Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy". Curr. Eye Res. 15 (11): 1117–1123. doi:10.3109/02713689608995143. PMID8950506.
Wolf WC, Harley RA, Sluce D, Chao J, Harley RA (1999). "Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands". Histochem. Cell Biol. 110 (5): 477–484. doi:10.1007/s004180050309. PMID9826127. S2CID25547665.
Wolf WC, Harley RA, Sluce D, Chao L, Chao J (1999). "Localization and expression of tissue kallikrein and kallistatin in human blood vessels". J. Histochem. Cytochem. 47 (2): 221–8. doi:10.1177/002215549904700210. PMID9889257. S2CID1126556.
Bläckberg M, Berling R, Ohlsson K (2000). "Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin". Pancreas. 19 (4): 325–334. doi:10.1097/00006676-199911000-00002. PMID10547191.
Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochim. Biophys. Acta. 1479 (1–2): 237–46. doi:10.1016/S0167-4838(00)00044-3. PMID10862973.
Pimenta DC, Oliveira A, Juliano MA, Juliano L (2001). "Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin". Biochim. Biophys. Acta. 1544 (1–2): 113–22. doi:10.1016/S0167-4838(00)00209-0. PMID11341921.