N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene.[5][6][7][8] The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to N6-methyllysine residue.
This histone modification is often abbreviated H4K20me1:
- H4 - type of histone
- K - symbol of lysine
- 20 - position of the lysine residue modified
- me - abbreviation for methyl group
- 1 - number of methyl groups transferred
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183955 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049327 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Couture JF, Collazo E, Brunzelle JS, Trievel RC (June 2005). "Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase". Genes & Development. 19 (12): 1455–65. doi:10.1101/gad.1318405. PMC 1151662. PMID 15933070.
- ^ Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D (June 2002). "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin". Molecular Cell. 9 (6): 1201–13. doi:10.1016/S1097-2765(02)00548-8. PMID 12086618.
- ^ Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y (July 2002). "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase". Current Biology. 12 (13): 1086–99. Bibcode:2002CBio...12.1086F. doi:10.1016/S0960-9822(02)00924-7. PMID 12121615. S2CID 15504308.
- ^ "Entrez Gene: KMT5A lysine methyltransferase 5A [ Homo sapiens (human) ]".
Further reading
- Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD (December 1996). "The TAF(II)250 subunit of TFIID has histone acetyltransferase activity". Cell. 87 (7): 1261–70. doi:10.1016/S0092-8674(00)81821-8. PMID 8980232. S2CID 18409257.
- Rice JC, Nishioka K, Sarma K, Steward R, Reinberg D, Allis CD (September 2002). "Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes". Genes & Development. 16 (17): 2225–30. doi:10.1101/gad.1014902. PMC 186671. PMID 12208845.
- Schlisio S, Halperin T, Vidal M, Nevins JR (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
- Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ (February 2003). "Structure and catalytic mechanism of the human histone methyltransferase SET7/9" (PDF). Nature. 421 (6923): 652–6. Bibcode:2003Natur.421..652X. doi:10.1038/nature01378. PMID 12540855. S2CID 4423407.
- Xiao B, Jing C, Kelly G, Walker PA, Muskett FW, Frenkiel TA, Martin SR, Sarma K, Reinberg D, Gamblin SJ, Wilson JR (June 2005). "Specificity and mechanism of the histone methyltransferase Pr-Set7". Genes & Development. 19 (12): 1444–54. doi:10.1101/gad.1315905. PMC 1151661. PMID 15933069.
- Yin Y, Liu C, Tsai SN, Zhou B, Ngai SM, Zhu G (August 2005). "SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20". The Journal of Biological Chemistry. 280 (34): 30025–31. doi:10.1074/jbc.M501691200. PMID 15964846.
- Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW, Dutta S, Appella E, Gozani O (August 2007). "Modulation of p53 function by SET8-mediated methylation at lysine 382". Molecular Cell. 27 (4): 636–46. doi:10.1016/j.molcel.2007.07.012. PMC 2693209. PMID 17707234.
- Tanaka H, Takebayashi SI, Sakamoto A, Igata T, Nakatsu Y, Saitoh N, Hino S, Nakao M (February 2017). "The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling". Cell Reports. 18 (9): 2148–2161. doi:10.1016/j.celrep.2017.02.021. PMID 28249161.
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This page was last edited on 3 April 2024, at 15:47