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SNX4

Identifiers

SNX4, ATG24B, sorting nexin 4

External IDs

OMIM: 605931 MGI: 1916400 HomoloGene: 36143 GeneCards: SNX4

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q21.2	Start	125,446,650 bp^[1]
Band	3q21.2	End	125,520,202 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B3	Start	33,071,812 bp^[2]
Band	16\|16 B3	End	33,120,639 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

jejunal mucosa

Achilles tendon

kidney tubule

ganglionic eminence

islet of Langerhans

duodenum

tibia

pancreatic ductal cell

rectum

Top expressed in

atrioventricular valve

left lung lobe

endocardial cushion

sciatic nerve

yolk sac

ureter

primitive streak

medullary collecting duct

calvaria

dermis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding transferrin receptor binding lipid binding
Cellular component	cytoplasm extrinsic component of membrane endosome early endosome membrane membrane plasma membrane SNARE complex cytoplasmic dynein complex protein-containing complex early endosome
Biological process	endocytosis vesicle organization endocytic recycling protein transport positive regulation of histamine secretion by mast cell
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8723


69150

Ensembl


ENSG00000114520


ENSMUSG00000022808

UniProt


O95219


Q91YJ2

RefSeq (mRNA)


NM_003794


NM_080557

RefSeq (protein)


NP_003785


NP_542124

Location (UCSC)

Chr 3: 125.45 – 125.52 Mb

Chr 16: 33.07 – 33.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.^[5]^[6]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.^[6]

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Transcription

Interactions

SNX4 has been shown to interact with BIN1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
^ ^a ^b "Entrez Gene: SNX4 sorting nexin 4".
^ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10). England: 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment". Nat. Cell Biol. 9 (12): 1370–80. doi:10.1038/ncb1656. PMID 17994011. S2CID 23816176.
Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic. 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. hdl:10852/11339. PMID 17319803. S2CID 21600584.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. PMID 12668730.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.

v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 3 March 2023, at 22:22

SNX4

From Wikipedia, the free encyclopedia

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Transcription

Interactions

References

Further reading